HIV Pre-Exposure Prophylaxis Use on a Global Scale Among Men Who Have Sex with Men: A Systematic Review and Meta-Analysis.

Knowledge of the proportion of Pre-Exposure Prophylaxis (PrEP) use among men who have sex with men (MSM) and the specific gaps in PrEP use can stimulate enhanced focus on HIV prevention policies and programs. To summarize the proportion of PrEP use and explore the temporal trend in the proportion of PrEP use and factors associated with PrEP use among MSM on a global scale, we searched PubMed, Embase, Web of Science Core Collection, and APA PsycINFO for studies reporting on the use of HIV PrEP among MSM before April 2022. Freeman-Tukey double arc-sine transformation and random-effects models were used to pool estimates.

Modeling and correction of fringe patterns in Doppler asymmetric spatial heterodyne interferometry.

Doppler asymmetric spatial heterodyne (DASH) interferometry is a novel concept for observing atmospheric winds. This paper discusses a numerical model for the simulation of fringe patterns and a methodology to correct fringe images for extracting Doppler information from ground-based DASH measurements. Based on the propagation of optical waves, the fringe pattern was modeled considering different angular deviations and optical aberrations.

Correction to Dulaglutide Alleviates LPS-Induced Injury in Cardiomyocytes.

[This corrects the article DOI: 10.1021/acsomega.0c06326.

Chitosan and κ-carrageenan-derived nitrogen and sulfur co-doped carbon dots "on-off-on" fluorescent probe for sequential detection of Fe and ascorbic acid.

This study develops a high sensitive and selective "on-off-on" fluorescent probe for sequential detection of iron ion (Fe) and ascorbic acid (AA) based on nitrogen and sulfur co-doped carbon dots (N, S-CDs), which were synthesized by using chitosan and κ-carrageenan as raw materials through one-step hydrothermal protocol. The synthesized N,S-CDs possess particularly high quantum yield (QY = 59.31%), excellent stability and excitation dependent behavior, showing great potential for practical applications.

A novel LMNA indel mutation identified in a family with atrioventricular block and atrial fibrillation.

It is well known that many genetic factors are involved in the occurrence and progression of atrioventricular block (AV block) and atrial fibrillation (AF). However, the genetic variants discovered so far have only explained parts of these processes. More genes and variants remain to be identified.

Dulaglutide Alleviates LPS-Induced Injury in Cardiomyocytes.

Background And Purpose: Sepsis is a severe infection-induced disease with multiple organ failure, and sepsis-induced cardiomyopathy is a fatal condition. Inflammatory response and oxidative stress are reported to be involved in the development of sepsis-induced cardiomyopathy. Dulaglutide is a novel antidiabetic agent that is currently reported to exert an anti-inflammatory effect.

Dysregulated SREBP1c/miR-153 signaling induced by hypertriglyceridemia worsens acute pancreatitis and delays tissue repair.

Severe acute pancreatitis (AP) is a life-threatening disease with up to 30% mortality. Therefore, prevention of AP aggravation and promotion of pancreatic regeneration are critical during the course and treatment of AP. Hypertriglyceridemia (HTG) is an established aggravating factor for AP that hinders pancreatic regeneration; however, its exact mechanism remains unclear.

effects of nitrosyl hydrogen on cardiac function and sarcoplasmic reticulum calcium pump (SERCA2a) in rats with heart failure after myocardial infarction.

Background: Abnormal Ca2+ circulation in cardiomyocytes is an important cause of decreased myocardial contractility in failing hearts. Nitroxyl hydrogen (HNO) can oxidize Ca cycle-related proteins, alter their biological functions, promote Ca recovery as well as release, and enhance myocardial contractility. In this study, we aim to observe the effect of nitrosyl hydrogen (HNO) on the cardiac function of rats with heart failure and elucidate the underlying mechanism.

Thermally stable monolithic Doppler asymmetric spatial heterodyne interferometer: optical design and laboratory performance.

We report on a thermally stable monolithic Doppler asymmetric spatial heterodyne (DASH) interferometer with field-widening prisms for thermospheric wind measurements by observing the Doppler shift of the airglow emission. Analytical deduction and numerical simulation are applied to determine the central optical path difference, the thermal compensation condition and the field-widening design. A monolithic interferometer with optimized configuration was built and tested in the laboratory.

Advances in research on treatment of heart failure with nitrosyl hydrogen.

Heart failure is the end stage of various heart diseases such as ischemic heart disease, dilated cardiomyopathy, valvular heart disease, congenital heart disease, and hypertensive myocardial damage. It is characterized by a decrease in myocardial contractility, but there is currently no ideal treatment. Nitroxyl hydrogen (HNO) is considered to be a protonated form of NO.

Effective wind and temperature retrieval from Doppler asymmetric spatial heterodyne spectrometer interferograms.

This paper presents a method for wind velocity and Doppler temperature retrieval from interferograms of a Doppler asymmetric spatial heterodyne spectrometer. This method is based on the analytic representation of the signal and the subsequent algorithms. It turns out to be more robust than the conventional Fourier transform method at low SNR.

Lysophosphatidic Acid Is Associated With Cardiac Dysfunction and Hypertrophy by Suppressing Autophagy via the LPA3/AKT/mTOR Pathway.

Lysophosphatidic acid (LPA), as a phospholipid signal molecule, participates in the regulation of various biological functions. Our previous study demonstrated that LPA induces cardiomyocyte hypertrophy ; however, the functional role of LPA in the post-infarct heart remains unknown. Growing evidence has demonstrated that autophagy is involved in regulation of cardiac hypertrophy.

Alfvén waves as a solar-interplanetary driver of the thermospheric disturbances.

Alfvén waves have been proposed as an important mechanism for the heating of the Sun's outer atmosphere and the acceleration of solar wind, but they are generally believed to have no significant impact on the Earth's upper atmosphere under quiet geomagnetic conditions due to their highly fluctuating nature of interplanetary magnetic field (i.e., intermittent southward magnetic field component).