Publications by authors named "Jiyang Pan"
Purpose: Despite recent findings suggesting an altered gut microbiota in those suffering from insomnia disorder (ID), research into the gut microbiota, oral microbiota, serum metabolites, and their interactions in patients with ID is sparse.
Patients And Methods: We collected a total of 114 fecal samples, 133 oral cavity samples and 20 serum samples to characterize the gut microbiota, oral microbiota and serum metabolites in a cohort of 76 ID patients (IDs) and 59 well-matched healthy controls (HCs). We assessed the microbiota as potentially biomarkers for ID for ID by 16S rDNA sequencing and elucidated the interactions involving gut microbiota, oral microbiota and serum metabolites in ID in conjunction with untargeted metabolomics.
Article Synopsis
- - Cognitive Behavioral Therapy for Insomnia (CBT-I) is proven to be effective for treating insomnia, but its underlying neurophysiological mechanisms are not well understood.
- - This narrative review explores various scientific fields such as psychology, neurophysiology, and immunology to uncover how CBT-I may positively impact the central nervous system, immune response, and brain structure.
- - The review suggests that CBT-I enhances brain connectivity and gene expression linked to immune function, proposing an integrated model to guide future research into its neurophysiological effects.
Article Synopsis
- The study explored the functional connectivity (FC) of the anterior and posterior hypothalamus with the whole brain in patients with insomnia disorder (ID) and examined how these values relate to serum levels of neurotransmitters that promote arousal, specifically orexin-A and histamine.
- It included 30 ID patients and 30 healthy controls, using resting-state functional magnetic resonance imaging (RS-fMRI) to measure FC and enzyme-linked immunosorbent assay (ELISA) to determine serum concentrations of the neurotransmitters.
- Results showed decreased FC in specific brain regions among ID patients compared to healthy controls, along with higher levels of orexin-A and histamine; a correlation was found between FC in certain areas and
Article Synopsis
- Differentiating between bipolar disorder (BD) and major depressive disorder (MDD) is difficult in clinical settings; this study examines radiomic textural features from brain MRI scans as a potential solution.
- A total of 253 subjects (114 with BD, 139 with MDD) were analyzed using a new method to extract and combine various radiomic features along with gray matter volume data.
- The best classification model achieved strong results, suggesting that incorporating advanced radiomic features can enhance the diagnosis of BD and MDD, although the study's limitation includes data coming from only one center without external validation.
Background: The present study explored the serum glutamate (Glu), glutamine (Gln), glutamic acid dehydrogenase (GAD) concentrations and the mRNA expression levels of the N-methyl-D-aspartate receptor (NMDAR) NR1 subunit in the peripheral blood of patients with insomnia disorder (ID). To our knowledge, this is the first study showing an increase in the mRNA expression levels of the NMDAR NR1 subunit in patients with ID.
Methods: This study included 30 ID patients and 30 matched healthy controls.
Purpose: Converging evidence implicates the putamen in sleep-wake regulation. However, its role remains unclear. We hypothesized that metabolic abnormalities in the putamen are linked to insomnia disorder, which has not been previously addressed, and investigated putaminal N-acetylaspartate (NAA), choline (Cho), and creatine (Cr) in patients with insomnia disorder compared to healthy controls.
View Article and Find Full Text PDFObjectives: Nowadays, few studies have examined the relationships between sleep duration and abnormal gut health. In this study, we used data from the National Health and Nutrition Examination Survey (NHANES) to investigate the correlations between habitual sleep duration and abnormal bowel symptoms in adults.
Methods: This study included 11,533 participants aged ≥ 20 years from the NHANES conducted during 2005-2010.
Background: Understanding the evolution of circadian rhythm dysfunction and psychopathology in the high-risk population has important implications for the prevention of bipolar disorder. Nevertheless, some of the previous studies on the emergence of psychopathologies and circadian dysfunction among high-risk populations were inconsistent and limited.
Aims: To examine the prevalence rates of sleep and circadian dysfunctions, mental disorders and their symptoms in the offspring of parents with (O-BD) and without bipolar disorder (O-control).
Article Synopsis
- The study explores how the CYP2D6 enzyme affects the metabolism of paroxetine, an antidepressant, to improve precision dosing in treatment, particularly among Chinese Han patients with depressive or anxiety disorders.
- Conducted over 8 weeks with 921 patients, it categorizes participants based on their CYP2D6 metabolizer status and evaluates treatment outcomes, showing significant differences in drug concentration and efficacy across various metabolizer types.
- The research highlights the need for tailored dosing strategies based on metabolic phenotypes, with specific recommendations for dosage adjustments in both East Asian and non-East Asian populations, factoring in sex and ethnicity as important variables.
Article Synopsis
- The study examined how adding 20% enhanced biological phosphorus removal (EBPR) activated sludge to a bulking activated sludge (BAS) reactor improved sludge settleability and resolved bulking issues within 16 days.
- The process also led to BAS granulation in an additional 16 days, with EBPR activity helping to inhibit filamentous bacteria and support slow-growing organisms that fostered aggregation.
- Results indicated that this method not only controlled sludge bulking but also increased total nitrogen removal from 59.4% to 71.7% due to the formation of mature aerobic granular sludge (AGS).
Aims: The findings from previous epidemiological studies of the association between regional body fat and depressive symptoms have been unclear. We aimed to determine the association between the body fat in different regions and depressive symptoms based on data from the National Health and Nutrition Examination Survey (NHANES).
Methods: This study included 3393 participants aged ≥ 20 years from the NHANES performed during 2011-2018.
Article Synopsis
- * The study involved 45 patients with chronic insomnia and 30 healthy volunteers, employing ELISA technology to measure serum markers related to intestinal barrier function.
- * Results revealed that insomnia patients had worse sleep quality and longer wake times, along with reduced levels of certain intestinal markers, indicating a link between gut health and sleep quality.
The effect of neuroendocrine abnormalities on the risk of psychiatric readmission after hospitalization for bipolar disorder: A retrospective study.
Prog Neuropsychopharmacol Biol Psychiatry
March 2024
Background: The correlation between the endocrine system and bipolar disorder(BD) has been well recognized, yet the influence of neuroendocrine hormones on readmission risk post-hospitalization for BD remains largely unexplored. This retrospective cohort study was to scrutinize the impact of neuroendocrine functionality on the readmission of patients with BD post-hospitalization for mental disorders.
Methods: The dataset was derived from the electronic medical records of the First Affiliated Hospital of Jinan University in Guangzhou, China.
Purpose: This research aimed to investigate serum Zonula occludens-1 (ZO-1) and Claudin-5 (CLDN5) levels to show whether or not their eventual changes in patients with insomnia disorder could have etiopathogenetic importance. There was no research investigating serum ZO-1 and CLDN5 concentrations in insomnia disorder.
Patients And Methods: This study included 60 insomnia disorder patients and 45 normal controls.
Article Synopsis
- - The study investigated how red light affects sleep quality and mood in individuals with insomnia disorder (ID) compared to healthy individuals, using different light treatments before bedtime.
- - Results showed that those exposed to red light reported higher anxiety and negative emotions, along with decreased total sleep time and sleep efficiency, especially in the insomnia group.
- - Interestingly, while the healthy red light group fell asleep faster than those in white and black light groups, the insomnia group showed mixed outcomes, with some sleep parameters improving but also experiencing more awakenings.
Purpose: The COVID-19 pandemic has adversely impacted the mental health of the population. The current study aimed to determine the prevalence of depressive symptoms and sleep disturbances among Chinese college students during the COVID-19 pandemic and investigate the correlations between chronotypes, sleep quality, and depressive symptoms.
Participants And Methods: In the current study, 2526 college students responded anonymously to an online questionnaire survey from 26 May 2020 to 20 July 2020.
Objective: This study's objective is to assess the efficacy and safety of Pulsed Magnetic Therapy System (PMTS) in improving insomnia disorder.
Methods: Participants with insomnia disorder were randomly assigned to receive either PMTS or sham treatment for four weeks (n= 153; PMTS: 76, sham: 77). Primary outcomes are the Insomnia Severity Index (ISI) scores at week 0 (baseline), 1, 2, 3, 4 (treatment), and 5 (follow-up).
Article Synopsis
- - A study examined the relationship between serum albumin levels and depressive symptoms using data from 13,681 adults in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018.
- - Results showed a significant negative association, indicating that higher serum albumin concentrations are linked to fewer depressive symptoms, particularly in non-smokers.
- - The analysis used various statistical methods, including logistic and linear regression, and found that the highest albumin quartile was connected to a lower likelihood of depressive symptoms compared to the lowest quartile.
Aim: To explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder.
Methods: In this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia disorder and 30 normal controls were included. All subjects had a structured clinical interview with the Brief International Neuropsychiatric Disorder Interview, and PSQI was used to evaluate the sleep status of the subjects.
Objective: This study used a moderated mediation model to test the mediating effect of anxiety on the relationship between negative perfectionism and sleep quality and the moderating effect of COVID-19 epidemic risk perception during the COVID-19 pandemic in Chinese international students.
Materials And Methods: A sample of 239 Chinese international students from the south of China, was surveyed with the Negative and Positive Perfectionism Scale, the Pittsburgh Sleep Quality Index, the General Anxiety Disorder Scale, and the COVID-19 Epidemic Risk Perception Inventory. Version 23.
Background: Previous studies have noticed that systemic inflammation may alter the integrity of white matter. However, how the levels of serum cytokine affect the integrity of white matter in major depressive disorder (MDD) patients are unclear. Our study aimed to investigate the association between the inflammatory cytokine levels and white matter microstructure in drug-naïve patients with MDD pre- and post-treatment.
View Article and Find Full Text PDFBackground: Obesity is very common in patients with schizophrenia. We aimed to evaluate the influencing factors of obesity in community patients with deficit schizophrenia, to provide implication for schizophrenia management in community.
Methods: We selected patients with deficit schizophrenia who lived in 10 communities in our city from March 1 to June 30, 2021.
Advances in next-generation sequencing (NGS) have revolutionized microbial studies in many fields, especially in clinical investigation. As the second human genome, microbiota has been recognized as a new approach and perspective to understand the biological and pathologic basis of various diseases. However, massive amounts of sequencing data remain a huge challenge to researchers, especially those who are unfamiliar with microbial data analysis.
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