Publications by authors named "Jiyang Jin"
Rationale And Objectives: To develop radiomics and deep learning models for differentiating malignant and benign soft tissue tumors (STTs) preoperatively based on fat saturation T2-weighted imaging (FS-T2WI) of patients.
Materials And Methods: Data of 115 patients with STTs of extremities and trunk were collected from our hospital as the training set, and data of other 70 patients were collected from another center as the external validation set. Outlined Regions of interest included the intratumor and the peritumor region extending outward by 5 mm, then the corresponding radiomics features were extracted respectively.
Article Synopsis
- Apple Valsa canker disease, caused by Valsa mali, threatens apple tree growth, and this study explores the role of specific MAPK signaling pathway components (VmMkh1, VmMkk1, and VmSpm1) in this process.
- Deletion of these components slows growth, reduces the production and germination of conidia, and hampers survival under stress conditions (like high salinity and cell wall disruptors).
- The research indicates that these components are crucial in regulating various aspects like growth, stress response, and pathogenicity associated with Valsa mali.
Purpose: The aim of this study was to develop a radiomics model based on magnetic resonance imaging (MRI) for predicting metastasis in soft tissue sarcomas (STSs) treated with surgery.
Methods/patients: MRI and clinical data of 73 patients with STSs of the extremities and trunk were obtained from TCIA database and Jiangsu Cancer Hospital as the training set, data of other 40 patients were retrospectively collected at our institution as the external validation set. Radiomics features were extracted from both intratumoral and peritumoral regions of fat-suppressed T2-weighted images (FS-T2WIs) of patients, and 3D ResNet10 was used to extract deep learning features.
Apple Valsa canker disease, caused by Valsa mali Miyabe et Yamada, severely endangers the healthy growth of apple trees. The Som1, located downstream of the cyclic AMP-dependent protein kinase A (cAMP-PKA) pathway, plays crucial roles in the growth, development, morphological differentiation, and virulence of filamentous fungi. In this study, we identify and functionally characterize VmSom1, a homolog of Som1, in Valsa mali.
View Article and Find Full Text PDFApple canker disease, caused by , is one of the most serious apple tree diseases in China. is an important transcription factor that acts on the cyclic adenosine signaling pathway (cAMP/PKA), regulating the growth, development, morphological differentiation, and pathogenic forces of the pathogen. We perform transcriptome analysis of the deletion mutant and the wild-type strain 11-175 and identify a significantly differentially expressed gene, , a zinc finger motif transcription factor in .
View Article and Find Full Text PDFCarbon catabolite repression (CCR) is a very important mechanism for efficient use of carbon sources in the environment and is necessary for the regulation of fungal growth, development, and pathogenesis. Although there have been extensive studies conducted regarding this mechanism in fungi, little is yet known about the effects of genes on . However, based on the results obtained in this study for the identification of the gene in , it was determined that the gene was expressed at all stages of fungal growth, with self-repression observed at the transcriptional level.
View Article and Find Full Text PDFDespite the national strategic priority to achieve common prosperity, there still exist prominent discrepancies in financial asset allocation between Chinese urban and rural families, which requires a deeper, more comprehensive investigation. To fill this gap, the present research adopted a cultural perspective to investigate relevant issues by addressing the cognitive differences of residents between urban and rural families. Under the analytical framework of Hofstede's cultural values, this paper discusses the cognitive differences between urban and rural families in terms of financial asset allocation in the cultural dimensions of collectivism, individualism and uncertainty avoidance; hypotheses are accordingly developed.
View Article and Find Full Text PDFBecause of the coronavirus disease 2019 (COVID-19) pandemic, the traditional didactic teaching method that is practiced in Confucian culture, an Eastern cultural model, is being challenged by multiple alternative teaching modes. In Western cultures, the teaching behavior of teachers is dependent on their ability to influence the temperament of students; in contrast, teachers in Eastern cultures are influenced by changes in external environment (i.e.
View Article and Find Full Text PDFBackground: The extracellular volume fraction (ECV) derived from cardiac magnetic resonance imaging (MRI) is extensively used to evaluate myocardial fibrosis. However, due to the limited histological verification in healthy individuals, it remains unclear whether the size of cardiomyocytes may play a potential role in the physiological changes of ECV. The aim of this study was to examine the association between cardiomyocyte size and myocardial ECV by using a healthy porcine model.
View Article and Find Full Text PDFArticle Synopsis
- Sub-solid nodules (SSN) are often found in medical imaging and require urgent evaluation to prevent lung cancer due to potential malignancy.
- This study analyzed patients with SSN to identify small extracellular vesicles (sEVs) and their miRNA profiles, specifically discovering sEVs-miR-424-5p as a potential biomarker for lung cancer.
- A nomogram was created by integrating sEVs-miR-424-5p with key radiomic and clinical features to improve the prediction accuracy for distinguishing between malignant and benign nodules.
Purpose: To detect the expression level of HOTAIR in patients with papillary thyroid carcinoma (PTC) and further investigate its associations with the pathological stage, computed tomography (CT) characteristics and prognosis of these patients.
Methods: The expression level of HOTAIR was assessed in normal tissues and thyroid cancer tissues of PTC patients and nodular goiter tissues of patients with nodular goiter via reverse transcription-polymerase chain reaction (RT-PCR). Additionally, the relations of HOTAIR expression level with the clinicopathological features, CT characteristics and prognosis of PTC patients were analyzed.
[Clinical application of multidisciplinary team co-management in geriatric hip fractures].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
October 2019
Objective: To observe the clinical application of multidisciplinary team (MDT) treatment in the management of geriatric hip fractures and evaluate its effectiveness.
Methods: The clinical data of 76 elderly patients with hip fracture managed by MDT approach between August 2016 and February 2018 (MDT group) were retrospectively analyzed and compared with 102 patients managed by traditional orthopedics approach between January 2014 and December 2015 (conventional group). There was no significant difference in gender, age, fracture type, surgical procedure, and other general data between the two groups ( >0.
Objectives: To determine the performance of chemical shift signal intensity index (CS-SII) values for distinguishing minimal-fat renal angiomyolipoma (mfAML) from renal cell carcinoma (RCC) and to assess RCC subtype characterisation.
Methods: We identified eligible studies on CS magnetic resonance imaging (CS-MRI) of focal renal lesions via PubMed, Embase, and the Cochrane Library. CS-SII values were extracted by lesion type and evaluated using linear mixed model-based meta-regression.
Article Synopsis
- * The experiment involved blocking blood flow to a part of the heart for 90 minutes and then restoring it, followed by imaging and taking blood samples to measure heart injury markers.
- * Results showed that DWI was more effective at detecting heart damage within the first 4 hours after infarction compared to other imaging techniques and standard blood tests.
A micelle-like hybrid natural-artificial light-harvesting nanosystem was prepared through protein-framed electrostatic self-assembly of phycocyanin and a four-armed porphyrin star polymer. The nanosystem has a special structure of pomegranate-like unimolecular micelle aggregate with one phycocyanin acceptor in the center and multiple porphyrin donors in the shell. It can inhibit donor self-quenching effectively and display efficient transfer of excitation energy (about 80.
View Article and Find Full Text PDFArticle Synopsis
- Platelet-rich plasma (PRP) shows potential for treating intervertebral disc degeneration (IDD), but its short-lived growth factors limit continuous stimulation of damaged discs.
- This study analyzed the combined use of PRP and bone marrow-derived mesenchymal stem cells (BMSCs) in rabbits with induced early IDD, demonstrating enhanced disc repair compared to PRP alone or a control group.
- Results at 8 weeks post-treatment indicated significant restoration of the degenerated discs in the PRP-BMSC group, suggesting a more effective therapeutic strategy for early IDD recovery.
[Magnetic resonance evaluations of correlation of iron overload and osteoporosis in ovariectomized rats].
Zhonghua Yi Xue Za Zhi
February 2015
Objective: To explore the correlation between liver T(2)(*) value and bone mineral density (BMD) in ovariectomized (OVX) rats.
Methods: A total of 60 rats, including sham (n = 25) and OVX (n = 35) groups, underwent dual-energy X-ray absorptiometry (DEXA) and liver magnetic resonance (MR)-T(2)(*) mapping for lumbar vertebra BMD and T(2)(*) values before and after operation monthly for 4 timepoints. Also micro-computed tomography (micro-CT) and biochemical measurements were performed.
Objective: To explore the correlation between liver iron overload and bone mineral density (BMD) in an ovariectomy (OVX) rat model, using liver magnetic resonance (MR)-T2* and dual-energy X-ray absorptiometry (DEXA).
Methods: Sprague-Dawley rats received deferoxamine (DFO) or phosphate-buffered saline 3 months after bilateral OVX. MRI and DEXA were performed pre- and postoperatively.
Article Synopsis
- The study aimed to validate a quicker method for measuring the myocardial contrast partition coefficient (lambda) using magnetic resonance imaging, focusing on a specific time point after contrast injection.
- Researchers conducted tests on both healthy individuals and those with diabetes and hypertension, using a 3-Tesla MRI scanner, and compared results from a simplified two-point method to a more complex multi-point regression method.
- Results showed that the two-point method produced reliable lambda values shortly after contrast injection (6-8 minutes), demonstrating good correlation with the reference method, making it a practical option for accurate cardiac assessments.
Article Synopsis
- Lung recruitment maneuvers can reopen collapsed lung areas for better oxygen supply, while PEEP is used to maintain lung openness afterward.
- A study on dogs with two types of ARDS found that using optimal PEEP levels improves overall lung aeration but also increases regions of hyperinflation, especially after lung recruitment.
- Hyperinflation was more pronounced in the surfactant depletion model compared to the oleic acid model, indicating that focal lung injuries are more vulnerable to hyperinflation when optimal oxygenation is targeted post-recruitment.
A hybrid hydrogel (PP) composed of Polomaxer-407 (PO) and octapeptide with amino acid sequence of KFEFKFEF (PE) was prepared to make a scaffold material incorporating PO's high and tunable mechanical strength and integrity with PE's superior bioactivity. Human adipose-derived mesenchymal stem cells (hASCs) were encapsulated into PE, PO and PP hydrogels respectively and injected subcutaneously at the dorsal neck area of nude mice. Adipose-like tissue regeneration was only observed in the mice injected with cell-encapsulated PP hydrogel.
View Article and Find Full Text PDFArticle Synopsis
- The article investigates how different injection sites (head, arm, leg) affect image quality and radiation exposure in pediatric cardiovascular CT angiography using 64-MDCT technology.
- The study involved 61 children, measuring various metrics like signal-to-noise ratio and effective dose across three different groups based on injection site.
- Results showed no significant differences in overall image quality but noted slight variations in aorta image quality and significant differences in radiation dose, suggesting the need for optimizing prescanning protocols to minimize exposure.
[Diagnostic value of 64 multislice CT in typing of congenital aortic anomaly in neonates and infants].
Zhonghua Yi Xue Za Zhi
August 2010
Article Synopsis
- - The study evaluates the effectiveness of 64-slice multislice CT (MSCT) in diagnosing congenital aortic anomalies in infants, finding it to be highly accurate with diagnostic sensitivity, specificity, and accuracy all at 100%.
- - A total of 120 pediatric patients with congenital heart disease underwent MSCT, revealing 36 congenital aortic anomalies, which included various types such as coarctation of the aorta and different aortic arch configurations.
- - The findings suggest that while MSCT provides detailed anatomical assessments necessary for surgical planning, using 80 kV for CT scans in infants under one year old is recommended to minimize radiation exposure.
Article Synopsis
- The study investigates whether mesenchymal stem cells (MSCs) labeled with magnetic nanoparticles can become liver cells (hepatocytes) when injected into mice with liver damage from carbon tetrachloride (CCl4).
- Researchers created a mouse model to track these MSCs using magnetic resonance imaging (MRI) and found that the labeled cells migrated to the liver, although they showed limited liver function improvement.
- Histological analysis confirmed liver damage and fibrosis in the MSC-injected groups, with a high correlation between labeled MSCs and the presence of liver-specific proteins, indicating some transdifferentiation into functional liver cells.
Purpose: The purpose of this study was to detect and follow transplanted superparamagnetic iron oxide (SPIO)-labeled endothelial progenitor cells (EPCs) by magnetic resonance imaging (MRI).
Procedures: Infarcted rats were randomized to injections of SPIO-labeled EPCs, unlabeled EPCs, or saline. From 1 day to 8 weeks, in vivo serial MRI was performed for cell tracking.