Publications by authors named "Jiyan Chen"
Chronic kidney disease (CKD) is prevalent among patients with coronary artery disease (CAD) and exacerbates myocardial ischemia. However, the survival benefit of percutaneous coronary intervention (PCI) across different stages of CKD remains controversial. CAD patients ( = 17,418) with CKD (mean age, 69.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) represents one of the most significant risks for death, in patients with existed cardiovascular disease (CVD). This study aimed to investigate whether the excess risk of death in these patients could be reduced or eliminated through joint intensive control of blood pressure, glucose and renin-angiotensin system inhibitors (RASi) treatment, among CVD patients with CKD.
Method: Overall, 6222 CVD patients with CKD and 9274 matched CVD patients who were free of CKD, hypertension and diabetes from CIN II cohort (NCT05050877), were included in the study.
Background And Aims: Heterozygous familial hypercholesterolemia (HeFH) is a prevalent autosomal dominant disorder of lipid metabolism but severely underdiagnosed and undertreated in China. This phase 3 trial aims to evaluate the efficacy and safety of ongericimab, a novel monoclonal antibody that targets proprotein convertase subtilisin/kexin type 9 (PCSK9), in Chinese patients with HeFH.
Methods: Patients who have been diagnosed with definite HeFH according to Dutch Lipid Clinical Network criteria and receiving stable and optimized lipid-lowering therapy were enrolled.
Antegrade wiring (AW) is the prevailing chronic total occlusion (CTO) crossing technique. For proximal cap ambiguity, the Global CTO consensus group uses the "anatomy dictates strategy" method: 1) intravascular ultrasound; 2) move the cap; or 3) retrograde. For CTO body crossing, anatomy dictates 4 strategies: 1) CTOs with tapered stump-loose tissue tracking; 2) CTOs with clear intimal path-intentional intimal tracking with 3-dimensional (3D) wiring; 3) CTOs without a clear intimal path-intentional intimal tracking with intermediate penetration wire; and 4) the "long plus CTOs"-intentional subintimal wiring.
View Article and Find Full Text PDFArticle Synopsis
- - A study at Guangdong Pharmaceutical University analyzed 22,317 adults to assess the prevalence of tricuspid regurgitation (TR) detected through Doppler echocardiography from 2015 to 2019, finding that 10.3% had significant TR.
- - The study revealed that the prevalence of significant TR increases with age, with rates jumping from 3.3% in those under 45 to 22.3% in those over 75.
- - Risk factors for significant TR included age, male gender, certain heart conditions, and pericardial effusion, with logistic regression identifying predictors like right ventricular dysfunction and enlargement of the right atrium.
Overweight/obesity among adolescents in Shandong Province, China, has been rising, posing significant public health challenge. Comprehensive investigation is needed to develop effective interventions. Following the Strengthening the Reporting of Observational Studies in Epidemiology guidelines, a stratified random cluster sampling approach was used from September to October 2023 across 17 cities in Shandong Province.
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- The study examines the impact of different glycemia levels on mortality risk in young patients with premature coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI).
- It included 14,585 patients, categorizing them into normal, intermediate, and high glycemia based on their HbA1c levels, with findings indicating that both hyperglycemia and intermediate hyperglycemia were linked to increased mortality risk.
- The research suggests that patients with intermediate hyperglycemia have an elevated mortality risk, indicating a need for glucose-lowering therapies in this group to potentially improve outcomes.
Article Synopsis
- Patients with secondary mitral regurgitation (sMR) and coronary artery disease (CAD) who undergo percutaneous coronary intervention (PCI) often face increased mortality and other health issues, with their condition being influenced by specific risk factors.
- This study examined the significance of the wall motion score index (WMSI) as a prognostic tool in predicting outcomes for sMR patients after PCI, revealing that around 40% still had severe sMR shortly after the procedure.
- Findings indicate that a higher WMSI after PCI is linked to worse outcomes, including persistent sMR, worsening heart failure, and increased mortality risk, highlighting the need for ongoing monitoring of WMSI in these patients.
Background: Despite the considerable progress made in preventative methods, medication, and interventional therapies, it remains evident that cardiovascular events (CVEs) continue to be the primary cause of both death and morbidity among individuals diagnosed with coronary artery disease (CAD).
Objective: To compare the connection between lipoprotein a (Lp[a]), fibrinogen (Fib), and both parameters combined with all-cause mortality to detect their value as prognostic biomarkers.
Methods: This is a retrospective study.
Background: The previous first-in-human study established the preliminary safety and effectiveness of the novel thin-strut iron bioresorbable scaffold (IBS). The current study aims to directly compare the imaging and physiological efficacy, and clinical outcomes of IBS with contemporary metallic drug-eluting stents (DES).
Methods: A total of 518 patients were randomly allocated to treatment with IBS (257 patients) or metallic DES (261 patients) from 36 centers in China.
Background: A phase 3 trial was conducted to evaluate the efficacy and safety of ongericimab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9, as an add-on treatment to optimized lipid-lowering therapy in Chinese patients with primary hypercholesterolemia and mixed dyslipidemia.
Methods And Results: A total of 806 patients who were receiving stable and optimized lipid-lowering therapy but did not achieve their low-density lipoprotein cholesterol (LDL-C) targets were enrolled and randomly assigned in a 2:1:2:1 ratio to receive either ongericimab 150 mg or matching placebo every 2 weeks, or ongericimab 300 mg or matching placebo every 4 weeks for 52 weeks. Efficacy and safety were evaluated in 802 patients who received at least 1 dose of ongericimab or placebo.
Article Synopsis
- The study investigates the link between stress hyperglycemia and contrast-associated acute kidney injury (CA-AKI) in patients undergoing coronary angiography (CAG), highlighting how dysglycemia plays a crucial role in this context.
- Using a large cohort of 19,965 participants, the research found a reverse J-shaped association between the stress hyperglycemia ratio (SHR) and the occurrence of CA-AKI, indicating that both low and high SHR values may be linked to higher injury risk.
- The findings suggest that assessing SHR prior to CAG can help identify patients at greater risk of CA-AKI, enhancing the predictive accuracy of existing models like the Mehran score.
Article Synopsis
- Inflammation plays a crucial role in coronary atherosclerosis and type 2 diabetes, with the platelet-to-HDL-cholesterol ratio (PHR) emerging as a significant biomarker for coronary artery disease risk.
- A study involving 56,316 CAD patients explored the relationship between PHR levels and mortality, categorizing participants based on their PHR and glycemic status, revealing that higher PHR levels correlate with increased all-cause and cardiac mortality.
- Results indicated that those with high PHR and diabetes faced the greatest mortality risk, emphasizing the need for integrated approaches to manage patients with elevated PHR in clinical settings.
In this paper, the MnO catalysts with excellent toluene oxidation performance were prepared by a simple precipitation method. The physicochemical properties of the prepared MnO catalysts were investigated by XRD, BET, H-TPR, O-TPD and XPS. The obtained results revealed that the crystallinity of the prepared MnO catalysts could be effectively regulated by changing the (NH)CO/Mn(NO) molar ratio, and thus affecting the oxygen vacancy concentration of the prepared MnO catalysts.
View Article and Find Full Text PDFDevelopment of non-surgical treatment of human abdominal aortic aneurysm (AAA) has clinical significance. Colchicine emerges as an effective therapeutic regimen in cardiovascular diseases. Yet, whether colchicine slows AAA growth remain controversy.
View Article and Find Full Text PDFBackground: The ISCHEMIA trial found that patients with chronic coronary disease randomized to invasive strategy had better health status than those randomized to conservative strategy. It is unclear how best to translate these population-level results to individual patients.
Objectives: The authors sought to identify patient characteristics associated with health status from invasive and conservative strategies, and develop a prediction algorithm for shared decision-making.
Background: Acute myocardial infarction (AMI) is characterized by inflammation, oxidative stress, and atherosclerosis, contributing to increased mortality risk. High-density lipoprotein (HDL) takes a crucial part in mitigating atherosclerosis and inflammation through its diverse functionalities. Conversely, fibrinogen is implicated in the development of atherosclerotic plaques.
View Article and Find Full Text PDFAims: The long-term cost-effectiveness of MitraClip in heart failure patients with secondary mitral regurgitation is still unclear. This study aimed to evaluate the long-term cost-effectiveness of MitraClip added to guideline-directed medical therapy vs. guideline-directed medical therapy alone in heart failure patients with secondary mitral regurgitation from the perspective of the healthcare systems of mainland China, the United Kingdom, Germany, and the United States.
View Article and Find Full Text PDFSerum creatinine (SCr) levels are essential for the diagnosis of kidney disease after coronary angiography (CAG). However, the influence of missed post-procedure SCr measurement in this situation is unclear. The present study included 14,127 patients undergoing CAG as part of the Cardiorenal ImprovemeNt registry II.
View Article and Find Full Text PDFBackground: The prognostic value of triglyceride-glucose (TyG) index in general type 2 diabetes mellitus (T2DM) patients is still unclear. Therefore, we aimed to determine the associations between TyG and all-cause/cause-specific death in a T2DM cohort and explore whether such associations would be modified by age.
Methods: A total of 3,376 patients with T2DM from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were selected and divided into the younger group (< 65 yrs) and the older group (≥ 65 yrs).
Article Synopsis
- The Ediacaran Doushantuo phosphate deposit in China is primarily composed of reconstituted phosphorite, but few studies have focused on its primary forms, leading to debates about how these phosphate-rich deposits formed.
- Researchers identified high-grade primary phosphorites in the region and conducted a comprehensive study, revealing various types of phosphorites rich in biological structures, mostly fossils of benthic red algae.
- The phosphorites indicate that the original ore bed resembled a reef, with geochemical data suggesting deposition in clear, oxygenated waters, highlighting the important role of algae in the formation of these deposits.
Introduction: Perioperative rehabilitation (PORT) has shown a positive effect on patients undergoing cardiac surgery. However, there are minimal data on the impact of short-term PORT in cardiac surgery, which is associated with higher postoperative morbidity and mortality. The trial will assess the efficacy of short-term PORT in reducing in-hospital mortality, postoperative pulmonary complications and length of stay, compared with the usual care in cardiac surgical patients.
View Article and Find Full Text PDFASSESS-IE: a Novel Risk Score for Patients with Infective Endocarditis.
J Cardiovasc Transl Res
June 2024
Mortality in patients with infective endocarditis (IE) remains high. The existing risk scores are relatively complex with limited clinical application. This study was conducted to establish a new risk model to predict in-hospital and 6-month mortality in IE patients.
View Article and Find Full Text PDFBackground And Aims: Secondary mitral regurgitation (sMR), a major valvular disease, is prevalent in patients with coronary artery disease (CAD), and is associated with higher incidence of heart failure (HF) and mortality when present in combination with abnormal glucose metabolism. We aimed to evaluate the relationship between stress hyperglycemia ratio (SHR) and worsening HF in CAD patients with significant (grade ≥2) sMR.
Methods: We performed a multi-center observational study of 874 participants with significant sMR following percutaneous coronary intervention (PCI) in the Cardiorenal Improvement-II (CIN-II) cohort.