Ginsenoside Rb1 ameliorates hippocampal neuroinflammation in rats after intracerebral hemorrhage by inactivating the TLR4/NF-kB pathway.

Purpose: This work elucidated the therapeutic effect and mechanism of ginsenoside Rb1 on intracerebral hemorrhage (ICH).

Methods: ICH rat models were treated by ginsenoside Rb1. Modified neurological deficit score, and Y-maze and Morris water-maze tests were performed on rats.

Smartphone-Based and Data-Driven Superstructure State Prediction Method for Highway Bridges in Service.

Survival analysis is a data-driven approach that is widely used in various fields of biomedical prognostic research, and it is highly reliable in the processing of time-event data. This study developed a method for evaluating the service performance of bridge superstructures using the built-in acceleration sensor of smartphones and the prediction of survival analysis theory. It will be used to assist in the daily maintenance and repair of small and medium bridges.

Analysis of bioactive components and pharmacokinetics of in rat plasma after oral administration by UPLC-ESI-MS/MS.

A UPLC-MS/MS method was developed and validated the determination and pharmacokinetic study of magnoflorine, cauloside C, hederagenin, and oleanolic acid from . Digoxin was used as the internal standard. The pretreated plasma samples were carried out on a Waters ACQUITYUPLC HSS T3 column at 35 °C with a mobile phase of acetonitrile-water (90:10, v/v) at a flow rate of 0.

Pharmacological Effect of on Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-B, and Proinflammatory Cytokines In Vivo and In Vitro.

Maxim has commonly been used as traditional Chinese medicine for the treatment of rheumatic pain and rheumatoid arthritis (RA) in China. This paper first investigated the anti-inflammation effect of extraction (CRME) on RAW264.7 cells stimulated by lipopolysaccharide (LPS) and gene expression levels of inflammatory factors.

Spectrum-Effect Relationships between Fingerprints of Caulophyllum robustum Maxim and Inhabited Pro-Inflammation Cytokine Effects.

Maxim (CRM) is a Chinese folk medicine with significant effect on treatment of rheumatoid arthritis (RA). This study was designed to explore the spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and the anti-inflammatory effects of CRM. Seventeen common peaks were detected by fingerprint similarity evaluation software.