Publications by authors named "Jiwoo Kim"

Background: The World Health Organisation (WHO) has identified a range of symptomatic manifestations to aid in the clinical diagnosis of post-COVID conditions, herein referred to as post-acute COVID-19 symptoms. We conducted an international network cohort study to estimate the burden of these symptoms in North American, European, and Asian populations.

Methods: A federated analysis was conducted including 10 databases from the United Kingdom, Netherlands, Norway, Estonia, Spain, France, South Korea, and the United States, between September 1st 2020 and latest data availability (which varied from December 31st 2021 to February 28th 2023), covering primary and secondary care, nationwide registries, and claims data, all mapped to the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM).

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Inositol pyrophosphates are eukaryotic signaling molecules that have been recently identified as key regulators of plant phosphate sensing and homeostasis. Given the importance of phosphate to current and future agronomic practices, we sought to design plants, which could be used to sequester phosphate, as a step in a phytoremediation strategy. To achieve this, we expressed diadenosine and diphosphoinositol polyphosphate phosphohydrolase (DDP1), a yeast (Saccharomyces cerevisiae) enzyme demonstrated to hydrolyze inositol pyrophosphates, in Arabidopsis thaliana and pennycress (Thlaspi arvense), a spring annual cover crop with emerging importance as a biofuel crop.

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  • - Low doses of anesthetics like ketamine and dexmedetomidine show anxiety-reducing effects that are independent of their sedative qualities, but how they work is still not fully understood.
  • - Researchers found a specific group of GABAergic neurons, called ovBNST, that respond to anesthetics and anxiolytic drugs, forming connections with brain areas involved in managing anxiety and stress.
  • - Activating these ovBNST neurons can significantly reduce anxiety behaviors, while shutting them down increases anxiety, indicating their role in managing autonomic responses and suggesting they could be a target for treating anxiety disorders.
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  • * Researchers analyzed data from over 42,000 patients, identifying key variables like age, sex, and health conditions that affect long-term survival.
  • * A predictive tool named SMART-M was developed, showing strong performance with C-statistics of approximately 0.806 for the training group and 0.803 for the validation group, indicating its reliability in mortality prediction.
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This study investigates the effectiveness of multiple COVID-19 vaccinations on daily confirmed cases in Seoul City. Utilizing comprehensive data on vaccinated individuals and confirmed cases sourced from the official website of the Korean Ministry of the Interior and Safety, we conducted detailed statistical analyses to assess the impact of each vaccination dose. The study covers data from April 21, 2021, to September 29, 2022.

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Notum is a direct target of Wnt/β-catenin signaling and plays a crucial role as a Wnt inhibitor within a negative feedback loop. In the tooth, Notum is known to be expressed in odontoblasts, and severe dentin defects and irregular tooth roots have been reported in Notum-deficient mice. However, the precise expression pattern of Notum in early tooth development, and the role of Notum in crown and root patterns remain elusive.

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Introduction: Involvement in sexual activities increases during adolescence in many countries, including Cambodia. The objective of this study is to explore the perspectives and interpretations of sex held by Cambodian adolescents within the context of their social norms and culture.

Methods: A qualitative research design was used to conduct in-depth interviews with a purposive sample of 91 Cambodian adolescents aged between 15 and 19 years.

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The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD-linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and mitochondrial FAD-linked glycerol 3-phosphate dehydrogenase 2 (GPD2). These two enzymes work together to act as an NADH shuttle for mitochondrial bioenergetics and function as an important bridge between glucose and lipid metabolism. Since these genes were discovered in the 1960s, their abnormal expression has been described in various metabolic diseases and tumors.

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Three-dimensional (3D) microfabrication techniques play a crucial role across various research fields. These techniques enable the creation of functional 3D structures on the microscale, unlocking possibilities for diverse applications. However, conventional fabrication methods have limits in producing complex 3D structures, which require numerous fabrication steps that increase the costs.

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The continuous monitoring of civil infrastructures is crucial for ensuring public safety and extending the lifespan of structures. In recent years, image-processing-based technologies have emerged as powerful tools for the structural health monitoring (SHM) of civil infrastructures. This review provides a comprehensive overview of the advancements, applications, and challenges associated with image processing in the field of SHM.

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  • Accurate medical diagnostics require the simultaneous measurement of multiple proteins, and a new method using multiplex colorimetric immunoassay with encoded hydrogel microparticles shows great potential.
  • Traditional methods face limitations in their dynamic range due to relying on end-point analysis, which requires precise timing to determine when to stop the reaction for accurate measurements.
  • This study improves upon existing techniques by implementing real-time signal analysis that tracks continuous changes in colorimetric signals, achieving over twice the dynamic range and greater sensitivity, demonstrated through applications related to pre-eclampsia.
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Background: To overcome the limitations of relying on data from a single institution, many researchers have studied data linkage methodologies. Data linkage includes errors owing to legal issues surrounding personal information and technical issues related to data processing. Linkage errors affect selection bias, and external and internal validity.

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  • - Statin therapy is effective in reducing cardiovascular events like recurrent ischemic stroke, even though it poses a risk for developing new-onset diabetes mellitus (NODM) in patients post-stroke.
  • - A study involving 20,250 patients showed that 67.7% were prescribed statins after an ischemic stroke, and those on statins had a significantly higher risk of NODM, especially after 3 years.
  • - Despite the increased risk of NODM linked to statin use, the therapy notably decreased the risk of recurrent ischemic strokes by 54% in these patients, highlighting a complex balance between benefits and risks.
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Background: The association between antihypertensive medication and schizophrenia has received increasing attention; however, evidence of the impact of antihypertensive medication on subsequent schizophrenia based on large-scale observational studies is limited. We aimed to compare the schizophrenia risk in large claims-based US and Korea cohort of patients with hypertension using angiotensin-converting enzyme (ACE) inhibitors versus those using angiotensin receptor blockers (ARBs) or thiazide diuretics.

Methods: Adults aged 18 years who were newly diagnosed with hypertension and received ACE inhibitors, ARBs, or thiazide diuretics as first-line antihypertensive medications were included.

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Background: Interactions of plants with biotic stress factors including bacteria, fungi, and viruses have been extensively investigated to date. Plasmodiophora brassicae, a protist pathogen, causes clubroot disease in Cruciferae plants. Infection of Chinese cabbage (Brassica rapa) plants with P.

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Unlabelled: Low doses of general anesthetics like ketamine and dexmedetomidine have anxiolytic properties independent of their sedative effects. How these different drugs exert these anxiolytic effects is not well understood. We discovered a population of GABAergic neurons in the oval division of the bed nucleus of the stria terminalis that is activated by multiple anesthetics and the anxiolytic drug diazepam (ovBNST ).

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Soil microbial communities with reduced complexity are emerging as model systems for studying consortia-scale phenotypes. To establish synthetic biology tools for studying these communities in hard-to-image environmental materials, we evaluated whether a single member of a model soil consortium (MSC) can be programmed to report on gene expression without requiring matrix disruption. For these studies, we targeted a five-membered MSC that includes , , sp003130705, sp001905665, and .

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, a brown seaweed, is known for its various health benefits; however, there are no reports on its effects on depression. This study aimed to investigate the antidepressant effects of ethanol extract (SHE) in mice injected with corticosterone (CORT) and to elucidate the underlying molecular mechanisms. Behavioral tests were conducted, and corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and CORT levels were measured.

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In this work, we report a bipolar electrode (BPE) array system with self-driven optical readouts of the faradic current flowing through the BPEs. The BPE array system is based on the spontaneous redox reactions that are respectively occurring at opposite poles of the BPEs with appropriate electrocatalysts on the poles; this system is analogous to one consisting of galvanic electrochemical cells. The galvanic BPE array system operates in a self-powered mode that requires there to be neither a direct electrical connection nor external electrical polarization to each BPE.

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Donor-acceptor (D-A) type molecules with a skeleton consisting of a dimethylaminonaphthalene donor and an oxazaborine acceptor were designed as efficient electrochemiluminescence (ECL) luminophores with tunable intramolecular charge transfer (ICT). The D-A ECL luminophores demonstrated that the ICT characteristics play a critical role in the electrochemistry and ECL of luminophores in the presence of tri--propylamine, which was rationalised experimentally and computationally. Furthemore, dual-peaked ECL-potential behaviours of the luminophores were rationalised using two competitive pathway ECL mechanisms, elucidated through the use of spooling ECL spectroscopy.

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Article Synopsis
  • The paper emphasizes the importance of transparent and FAIR (Findable, Accessible, Interoperable, Reusable) disclosure of healthcare data and infrastructure, which has been lacking in public awareness.
  • The authors developed a common data model (OMOP) using national claims data from South Korea's Health Insurance Review and Assessment Service, converting over 10 billion claims and data from 56 million patients.
  • They built an analytics environment for distributed research and made the data metadata publicly accessible, aiming to reduce information inequality among researchers and enhance the generation of high-quality medical evidence.
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Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular phospholipid metabolism and contributes to ferroptosis resistance. A metabolic drug screen reveals that darapladib, an inhibitor of Lp-PLA2, synergistically induces ferroptosis in the presence of GPX4 inhibitors.

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  • A study was conducted to evaluate a new method for accurately estimating breast volume before mastectomy, using the Vectra H2 technology.
  • Patients underwent skin-sparing mastectomy and immediate reconstruction, with their breasts being 3D scanned for preoperative and post-surgery comparisons.
  • Results showed a strong correlation between actual mastectomy weight and the estimated volume, indicating that three-dimensional imaging is a reliable and non-invasive tool for predicting breast volume in reconstruction.
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Objective: Noise quantification is fundamental to computed tomography (CT) image quality assessment and protocol optimization. This study proposes a deep learning-based framework, Single-scan Image Local Variance EstimatoR (SILVER), for estimating the local noise level within each region of a CT image. The local noise level will be referred to as a pixel-wise noise map.

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