Hydrophobic deep eutectic solvent-based eutectogels for underwater sensing.

Eutectogels derived from deep eutectic solvents (DESs) exhibit great potential for the fabrication of flexible sensors. However, the hygroscopicity of eutectogels hinders their applications in underwater sensing. In this work, a hydrophobic eutectogel with exceptional long-term underwater stability is produced through one-step polymerization of lauryl methacrylate and glycidyl methacrylate in a hydrophobic DES.

An integrated microfluidic detection system for the automated and rapid diagnosis of high-risk human papillomavirus.

Human papillomavirus (HPV) causes the prevalent sexually transmitted infection that accounts for the majority of cervical cancer incidences. Therefore, the development of a rapid, accurate, automatic and affordable nucleic acid detection strategy is urgently required for HPV tests, among which microfluidic chip is a promising diagnostic method. In this work, we developed a microfluidic detection system consisting of a microfluidic chip and the corresponding detection equipment to diagnose high-risk HPV.

Stretch-driven microfluidic chip for nucleic acid detection.

Molecular diagnosis is an essential means to detect pathogens. The portable nucleic acid detection chip has excellent prospects in places where medical resources are scarce, and it is also of research interest in the field of microfluidic chips. Here, the article developed a new type of microfluidic chip for nucleic acid detection where stretching acts as the driving force.

HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma.

Renal cell carcinoma (RCC) is responsible for most cases of the kidney cancer. Previous research showed that low serum levels of cholesterol level positively correlate with poorer RCC-specific survival outcomes. However, the underlying mechanisms and functional significance of the role of cholesterol in the development of RCC remain obscure.