-Mediated RNA Activation Upregulates Expression and Inhibits High-Glucose-Induced Apoptosis of Sheep Granulosa Cells.

The glucose metabolism homeostasis in the follicular fluid microenvironment plays an important role in follicular maturation and ovulation, and excessively high or low glucose concentrations have adverse effects on the differentiation of follicular granulosa cells (GCs). However, a limited number of microRNAs (miRNA) have been reported to be involved in glucose-stimulated GCs differentiation. In this study, we characterized the miRNA expression profiles of sheep ovarian GCs cultured in high-glucose and optimal glucose concentrations and focused on a differentially expressed miRNA: , which may be involved in regulating high-glucose-induced GC apoptosis by targeting .