Dapagliflozin promotes browning of white adipose tissue through the FGFR1-LKB1-AMPK signaling pathway.

Background: Obesity is associated with a wide variety of metabolic disorders that impose significant burdens on patients and society. The "browning" phenomenon in white adipose tissue (WAT) has emerged as a promising therapeutic strategy to combat metabolic disturbances. However, though the anti-diabetic drug dapagliflozin (DAPA) is thought to promote "browning," the specific mechanism of this was previously unclear.

Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice.

Background: Cognitive deficits and behavioral disorders such as anxiety and depression are common manifestations of Alzheimer's disease (AD). Our previous work demonstrated that Trichostatin A (TSA) could alleviate neuroinflammatory plaques and improve cognitive disorders. AD, anxiety, and depression are all associated with microglial inflammation.

Boosting CO chemical fixation over MOF-808 by the introduction of functional groups and defective Zr sites.

CO cycloaddition has emerged as a promising approach for producing value-added cyclocarbonates and mitigating greenhouse gas emissions. Although MOF-808 serves as a stable catalyst for cycloaddition, its limited activity constrains broader applications. Through the modification with a fluoride group a ligand exchange method, F-MOF-808-1.

Two-dimensional N-doped Pd/carbon for highly efficient heterogeneous catalysis.

A novel two-dimensional ZIF-derived Pd@CN material prepared one-step calcination exhibits outstanding catalytic activity in heterogeneous hydrogenation. Its well-developed porous structure, low dimensions and low density make active sites more accessible. This facile and effective strategy can guide the synthesis of highly active and durable Pd@CN catalysts with specific morphologies.