Halogen bonding accelerated aerobic dehydrogenative aromatization for 4-aminoquinoline preparation.

This study presents a highly efficient method for 4-aminoquinoline derivative preparation under transition metal-free conditions. The process involves an aerobic oxidative dehydrative coupling of 2,3-dihydroquinolin-4(1)-ones with various amines, including ammonia, resulting in high yields of the desired products. The method is also applicable to substituted 4-aminoquinoline derivative construction through a cyclization/dehydrative coupling cascade process starting from 2'-amino chalcones.