Can Regional Eco-Efficiency Forecast the Changes in Local Public Health: Evidence Based on Statistical Learning in China.

Regional eco-efficiency affects local public health through intermediaries such as economic and environmental impacts. Considering multiple factors, the implicit and uncertain relationship with regional characteristics, and the limited data availability, this paper investigated the forecasting of changes in local public health-including the number of visits to hospitals (VTH), outpatients with emergency treatment (OWET), number of inpatients (NI), number of health examinations (NOHE), and patients discharged (PD)-using calculated regional eco-efficiency with the Least Square-Support Vector Machine-Forecasting Model and acquired empirical evidence, utilizing the province-level data in China. Results: (1) regional eco-efficiency is a good predictor in both a single and multi-factor situation; (2) the prediction accuracy for five dimensions of the changes in local public health was relatively high, and the volatility was lower and more stable throughout the whole forecasting period; and (3) regional heterogeneity, denoted by three economic and demographic factors and three medical supply and technical level factors, improved the forecasting performance.

JTE-013 Alleviates Inflammatory Injury and Endothelial Dysfunction Induced by Sepsis In Vivo and In Vitro.

Background: Nowadays, there is no approved targeted agent for lung injury induced by sepsis. S1PR2 is confirmed to be a promising diagnosis and treatment target. JTE-013 as S1PR2 antagonists may be an agent of great potential.

In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging.

Noninvasive, easy-to-use and accurate measurements of wall shear stress (WSS) in human blood vessels have always been challenging in clinical applications. Echo particle image velocimetry (Echo PIV) has shown promise for clinical measurements of local hemodynamics and wall shear rate. Thus far, however, the method has only been validated under simple flow conditions.

A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress.

Background: The cellular responses of bacteria to superoxide stress can be used to model adaptation to severe environmental changes. Superoxide stress promotes the excessive production of reactive oxygen species (ROS) that have detrimental effects on cell metabolic and other physiological activities. To antagonize such effects, the cell needs to regulate a range of metabolic reactions in a coordinated way, so that coherent metabolic responses are generated by the cellular metabolic reaction network as a whole.

Wave scattering from encapsulated microbubbles subject to high-frequency ultrasound: contribution of higher-order scattering modes.

The theoretical understanding of encapsulated microbubble response to high-frequency ultrasound (HFUS) excitation is still limited although some novel experimental HFUS contrast imaging techniques have been well developed. In this paper, the higher-order modal (HOM) contributions to the scattered field are studied for such microbubbles driven by 1-100 MHz ultrasound. An exact solution of all small-amplitude vibrational modes of a single encapsulated microbubble in water is given by the wave scattering theory (WST) method and compared to results obtained from Church's Rayleigh-Plesset-like model for the small-amplitude radial oscillation of a microbubble in an incompressible fluid.

Improving metabolic flux estimation via evolutionary optimization for convex solution space.

Motivation: Flux estimation by using (13) C-labeling pattern information of metabolites is currently the only method that can give accurate, detailed quantification of all intracellular fluxes in the central metabolism of a microorganism. In essence, it corresponds to a constrained optimization problem which minimizes a weighted distance between measured and simulated results. Characteristics, such as existence of multiple local minima, non-linear and non-differentiable make this problem a special difficulty.

Study on the multiple scattering effects of ultrasound contrast agents.

In this paper, the multiple scattering of interacting encapsulated microbubbles in suspensions is calculated using two novel approaches--Kargl's effective medium approach and Ye and Ding's approach of 2nd-order correction. Two types of contrast agents with bubbles of different sizes and concentrations are chosen for our numerical simulations. One is Albunex, which is depicted by Church and has a size range of several microns, and the other is sodium laureate solution (before fractionation) described by Soetanto and Chan and has an average size of 35.

Ultrasound attenuation in encapsulated microbubble suspensions: The multiple scattering effects.

The phenomenon of image distortions caused by the multiple scattering (MS) effects of encapsulated microbubbles in ultrasoniqc imaging was experimentally found in previous studies (Soetanto and Chan 2000a), but its mechanism has not been fully understood. To study the MS effects of microbubbles in contrast imaging, two approaches are employed in this article--the effective medium approach initialized by Kargl (2002), which includes all the high-order rescattering of free bubbles, and the classic lowest-order approximation approach of Commander and Prosperetti (1989), which ignores the higher-order rescattering between bubbles. In this work, they are modified to model encapsulated microbubble suspensions, and the discrepancies in attenuation coefficients calculated by these two approaches, i.