Synthetic Fluororutaecarpine Inhibits Inflammatory Stimuli and Activates Endothelial Transient Receptor Potential Vanilloid-Type 1.

The natural product, rutaecarpine (RUT), is the main effective component of Evodia rutaecarpa which is a widely used traditional Chinese medicine. It has vasodilation, anticoagulation, and anti-inflammatory activities. However, further therapeutic applications are limited by its cytotoxicity.

Design and synthesis of ultrasensitive off-on fluoride detecting fluorescence probe via autoinductive signal amplification.

We prepared an off-on fluorometric probe, DPF1, by incorporating the concept of autoinductive signal amplification into its molecular design. In the presence of fluoride, DPF1 undergoes a cascade of self-immolative reactions concomitant with unmasking fluorogenic coumarin, which results in the ejection of two fluoride ions. These fluoride ions are continuously activating the cascade reaction and accumulating coumarins, which leads to exponentially amplifying the signal with high sensitivity.

Electrochemical OFF-ON ratiometric chemodosimeters for the selective and rapid detection of fluoride.

We have described two "OFF-ON electrochemical latent ratiometric redox chemodosimeters", 1,4-Bis(tert-butyldimethylsiloxy)benzene (H2Q') and 1,4-Bis (tert-butyldimet hylsiloxy)-2-methoxybenzene (MH2Q') for the selective detection of inorganic fluoride. The electrochemical signals of hydroquinone (H2Q) and o-methoxy hydroquinone (MH2Q) within this latent redox probes (H2Q' and MH2Q') were completely masked by protecting their hydroxyl group as silylether (OFF state). The externally added fluoride ions triggered the deprotection of H2Q' and MH2Q' and unmasked the electrochemical properties of H2Q and MH2Q respectively.

Vapor-based synthesis of maleimide-functionalized coating for biointerface engineering.

Chemical vapor deposition polymerization was used to deposit a novel maleimide-functionalized poly-p-xylylene coating on various substrates. The coated substrates are readily able to undergo thiol-maleimide click reaction under mild conditions. Applications using this coating technology are highlighted in low-protein-fouling modification as well as manipulated attachments and growth of bovine arterial endothelial cells.