Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude.

Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective treatment. Acer truncatum Bunge Seed extract (ASO) is reported to have effect on cognitive improvement, but its molecular mechanisms on HIE are unclear. In this study, ASO administration contributed to reduced neuronal cell edema and improved motor ability in HIE rats at a simulated 4500-meter altitude.

Lipidomics reveal the cognitive improvement effects of seed oil on hypoxic-ischemic encephalopathy rats.

Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of acute neonatal death and chronic neurological damage, and severe HIE can have secondary sequelae such as cognitive impairment and cerebral palsy, for which effective interventions are lacking. In this study, we found that continuous 30-day intake of seed oil (ASO) reduced brain damage and improved cognitive ability in HIE rats. Using lipidomic strategies, we observed that HIE rats had decreased unsaturated fatty acids and increased lysophospholipids in the brain.

Surfactant Therapy for Respiratory Distress Syndrome in High- and Ultra-High-Altitude Settings.

Objective: The objective of this study is to investigate the therapeutic effect of surfactant replacement therapy (SRT) on respiratory distress syndrome (RDS) in premature infants in the Qinghai-Tibet Plateau.

Materials And Methods: This multi-center retrospective cohort study collected and screened reasonable clinical data of 337 premature infants with RDS from 10 hospitals in the Qinghai-Tibet Plateau from 2015 to 2017. We grouped the cases by rationally analyzing their baseline characteristics, using logistic analysis to evaluate each factor's effect on the prognosis of the infants, and comparing the short-term improvement in blood gas and mortality after SRT treatment at different altitudes, in high-altitude (1,500-3,500 m) and ultra-high-altitude (3,500-5,500 m) groups.

Cognitive improvement effect of nervonic acid and essential fatty acids on rats ingesting seed oil revealed by lipidomics approach.

seed oil (ASO) is rich in ω-9 (53.93%) and ω-6 (30.7%) fatty acids (FAs) and characterized by 3-7% nervonic acid (NA, C24:1ω-9).

Factors Influencing Vitamin D Levels in Neonatal Umbilical Cord Blood: A Two-Center Study From Tibet and Shenyang.

To investigate the factors influencing the levels of vitamin D (vitD) in the umbilical cord blood of neonates born in Naqu, Tibet (4,500 m above sea level), and Shenyang, Liaoning Province (500 m above sea level). This prospective study was conducted from June 2017 to October 2018 in Naqu (the plateau group) and Shenyang, (the non-plateau group). Healthy mothers that gave birth to healthy neonates of >2,000g after 38 weeks' gestation were enrolled in the study, as were their neonates.

Iatrogenic Pleural Effusion Due to Extravasation of Parenteral Nutrition via an Epicutaneo Cava Catheter in Neonates: A Prospective Cohort Study.

Although Epicutaneo cava catheters (ECCs) are being routinely used for intravenous access for long-term parenteral nutrition and prolonged medication administration in neonates, ECC use can be associated with rare but acute life-threatening events such as pleural effusion (PE). It is important to identify and maintain the ECC tip in a central location for preventing complications. Recently, intracavitary electrocardiogram (IC-ECG) has been developed for the real-time monitoring and verification of ECC tip position.

Lactate levels and clearance rate in neonates undergoing mechanical ventilation in Tibet.

Objective: This study aimed to examine the characteristics of blood lactate in neonates undergoing mechanical ventilation in Tibet.

Methods: We recruited 67 neonates undergoing mechanical ventilation in Naqu People's Hospital as the plateau observation group and 94 neonates undergoing mechanical ventilation in Shengjing Hospital as the control group. We analyzed the differences in lactate levels between the two groups.

Marrow-derived mesenchymal stem cells regulate the inflammatory response and repair alveolar type II epithelial cells in acute lung injury of rats.

Objective: We investigated the effect of untransplantable bone marrow-derived mesenchymal stem cells (BMSCs) in acute lung injury (ALI) and whether BMSCs attenuate damage of lipopolysaccharide (LPS) to alveolar type II epithelial cells (AECIIs).

Methods: ALI models were prepared by nebulizing LPS and then BMSCs were infused 1 hour later. We observed histopathological changes of lung tissue and evaluated inflammatory exudation by the wet/dry weight ratio, bronchiolar lavage fluid cell count, and protein concentration determination.

Mechanical Ventilation in Neonatal Respiratory Distress Syndrome at High Altitude: A Retrospective Study From Tibet.

To explore the characteristics of mechanical ventilation parameters and the arterial partial pressure of oxygen in neonatal respiratory distress syndrome (RDS) at high altitude. From the 1st May 2017 to the 31st December 2018, we recruited 33 neonates with severe RDS who were undergoing mechanical ventilation in the NICU of Naqu People's Hospital in Tibet (4,580 m above sea level); these neonates formed a plateau observation group. We also recruited a non-plateau control group: 66 neonates with severe RDS undergoing mechanical ventilation of Shengjing Hospital in Liaoning (51 m above sea level).

[Interpretation of the disaster response plans in the pediatric intensive care unit].

In April 2018, the Group of Pediatric Disasters, Pediatric Society, Chinese Medical Association and Pediatric Committee, Medical Association of Chinese People's Liberation Army issued the disaster response plans in the pediatric intensive care unit (PICU). This article outlines the development of the plans and the implementation of PICU disaster rescue, along with ethical issues in the context of disasters and psychological reconstruction after a disaster.

A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents.

Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in the adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents.

[Relationship between fever degree and prognosis in children with bacterial bloodstream infection].

Objective: To study the relationship between the degree of fever within 48 hours of admission and the prognosis in children with bacterial bloodstream infection.

Methods: This study retrospectively analyzed the clinical data of all patients diagnosed with sepsis who were admitted to the pediatric intensive care unit (PICU) of Shengjing Hospital Affiliated to China Medical University between September 2008 and September 2016. The children with bacterial bloodstream infection were classified into 5 groups according to the maximum temperature within 48 hours of admission: <36.

Clinical report of serious complications associated with measles pneumonia in children hospitalized at Shengjing hospital, China.

Introduction: Despite tremendous progress made toward elimination, measles continues to pose a great threat to the health of children in developing countries. The objective of this study was to summarize and analyze the clinical characteristics and treatment experience of serious complications of measles pneumonia in children.

Methodology: The study group comprised 58 infants with severe measles pneumonia who were admitted to the Second Pediatric Intensive Care Unit, Shengjing Hospital of China Medical University, from December 2013 through May 2014.

[Risk factors for multidrug-resistant Klebsiella pneumoniae sepsis in children].

Objective: To explore the risk factors for sepsis caused by multidrug-resistant Klebsiella pneumonia (MDR-KP) and to provide a reference for the prevention of MDR-KP sepsis and rational use of antibiotics.

Methods: A retrospective case-control study of 41 children with MDR-KP sepsis (case group) and 53 pediatric patients without MDR-KP sepsis (control group) between March 2010 and Febrary 2014 was conducted. Multiple logistic regression analysis was performed to estimate the independent risk factors for MDR-KP sepsis.

[Investigation of disease spectrum in the PICU of Shengjing Hospital of China Medical University between 2005 and 2012].

Objective: To summarize the spectrum of disease and common diseases that cause death in children admitted to the Pediatric Intensive Care Unit (PICU), Shengjing Hospital of China Medical University between 2005 and 2012.

Methods: A retrospective analysis was carried out on the clinical data of 4484 children admitted to the PICU of Shengjing Hospital between 2005 and 2012.

Results: Acute bronchopneumonia, which was found in 1099 (24.

[Diagnostic value of serum CRP and procalcitonin levels in children with bloodstream infection-associated sepsis and septic infection at other sites].

Objective: To evaluate the diagnostic value of measuring serum C-reactive protein (CRP) and procalcitonin (PCT) levels, within 6 hours after admission to the pediatric intensive care unit (PICU) in children with bloodstream infection (BSI)-associated sepsis and septic infection at other sites.

Methods: A retrospective analysis was performed on 30 children with a confirmed diagnosis of systemic inflammatory response syndrome who were admitted to the Shengjing Hospital of China Medical University between January 2010 and January 2012. Clinical data on serum CRP, PCT and D-dimer levels were collected within 6 hours after admission.

Serotypes and patterns of antibiotic resistance in strains causing invasive pneumococcal disease in children less than 5 years of age.

Objective: The serotypes and patterns of antibiotic resistance of Streptococcus pneumoniae (S. pneumoniae) strains that cause invasive pneumococcal disease (IPD) in infants were analyzed to provide guidance for clinical disease prevention and treatment.

Methods: The clinical features of confirmed IPD were evaluated in 61 patients, less than 5 years of age, who were admitted to our hospital between January 2009 and December 2011.

[Characteristics of circulatory disturbance and the treatment of severe hand-foot-and-mouth disease].

Objective: To investigate the characteristics of circulatory disturbance and treatment of severe hand-foot-and-mouth disease (HFMD).

Method: The clinical characteristics, laboratory findings, therapy and outcome of 22 severe HFMD patients were retrospectively analyzed.

Result: All the 22 severe HFMD patients came from the countryside.

Findings in children severely infected with a novel influenza A virus of swine origin: pulmonary imaging.

Background: This article reviews the chest radiography of children with severe infection caused by a novel influenza A (H1N1) virus of swine origin (S-OIV). We analyzed the role of their pulmonary images in predicting the severity and diagnosis of the disease.

Methods: Among 97 patients with confirmed novel H1N1 infection, 42 patients treated with mechanical ventilation formed group 1, and the remaining 55 patients constituted group 2.

[Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease].

Objective: To study the correlation between the blood serum brain natriuretic peptide (BNP) level and the left cardiac function in children with congenital heart disease (CHD).

Methods: The clinical data of 41 CHD children were retrospectively analyzed. Patients were divided into two groups based on the existence of congestive heart failure (CHF): CHD+CHF (n=21) and CHD alone (n=20).

Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications.

Background: To explore the relationship between enteroviruses and hospitalized children with hand, foot and mouth disease (HFMD) complicated with nervous system disease. 234 hospitalized HFMD patients treated in Shengjing Hospital, Liaoning Province were analyzed retrospectively. Based on the presence and severity of nervous system disease, the patients were grouped as follows: general patients, severely ill patients, critically ill patients and fatal patients.

[Treatment of congenital heart disease complicated by severe bronchopneumonia in infants].

Objective: To study the treatment and the treatment outcome in infants with congenital heart disease complicated by severe pneumonia and heart failure.

Methods: The clinical data of 24 infants with congenital heart disease (left to right shunt) complicated by severe pneumonia and heart failure between January 2007 and December 2007 were retrospectively reviewed.

Results: Twenty-two infants recovered and 2 died.

[Etiology of acute upper respiratory tract obstruction in infants: analysis of 12 cases].

Objective: To study the etiology of acute upper respiratory tract obstruction in infants.

Methods: The medical data of 12 infants with acute upper respiratory tract obstruction were retrospectively reviewed. The patients received the examinations of laryngoscopy and CT scans for larynx and lungs.