Mapping Spatiotemporal Heterogeneity in Multifocal Breast Tumor Progression by Noninvasive Ultrasound Elastography-Guided Mass Spectrometry Imaging Strategy.

Spatiotemporal heterogeneity of tumors provides an escape mechanism for breast cancer cells, which can obstruct the investigation of tumor progression. While molecular profiling obtained from mass spectrometry imaging (MSI) is rich in biochemical information, it lacks the capacity for in vivo analysis. Ultrasound diagnosis has a high diagnostic accuracy but low chemical specificity.

A quantitative proteomic study reveals oxidative stress and synapse-related proteins contributed to TDCIPP exposure induced neurotoxicity.

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been consistently identified in various environmental media and biological specimens. Current understanding of the in vivo toxicities of TDCIPP is limited, especially for potential for neurotoxic and cognitive impairment effects. To better evaluate the potential adverse effect of the chemical on learning and memory, Sprague Dawley (SD) rats were administered TDCIPP via gavage at doses of 40, 120, and 360 mg/kg/day for a period of 90 days.

Intestinal obstruction caused by mesodiverticular band in children: a cohort study.

Objective: To explore clinical characteristics, pathogenesis, diagnosis and treatment of intestinal obstruction due to mesodiverticular band (MDB) in children in a single center in China.

Methods: The clinical data of 20 children with acute intestinal obstruction due to MDB between 1998 and 2020 were retrospectively analyzed.

Results: The male-to-female ratio was 14:6 in 20 cases.

Effects of Policy for Controlling Agricultural Non-Point Source Pollution in China: From a Perspective of Regional and Policy Measures Differences.

The concerns about the contradiction between agricultural production and Agricultural Non-Point (ANPS) pollution has become increased with economic development in China. Government interventions are key to controlling ANPS pollution through the establishment of laws and policies. This paper uses the entropy method to calculate the emissions amount of ANPS pollution and policy strength of 31 provinces from 2010 to 2019 in China.

Synthesis and HNO Donating Properties of the Piloty's Acid Analogue Trifluoromethanesulphonylhydroxamic Acid: Evidence for Quantitative Release of HNO at Neutral pH Conditions.

Trifluoromethanesulphonylhydroxamic acid, CF SO NHOH, is shown to release HNO under physiological pH conditions. A two-step synthesis is presented with the first complete characterization of CF SO NHOH. This molecule rapidly decomposes in neutral aqueous solution to cleanly release HNO and CF SO , which was demonstrated using the HNO traps TXPTS and HOCbl, and by F NMR spectroscopy.

Hierarchical Sandwich-Like Structure of Ultrafine N-Rich Porous Carbon Nanospheres Grown on Graphene Sheets as Superior Lithium-Ion Battery Anodes.

A sandwich-like, graphene-based porous nitrogen-doped carbon (PNCs@Gr) has been prepared through facile pyrolysis of zeolitic imidazolate framework nanoparticles in situ grown on graphene oxide (GO) (ZIF-8@GO). Such sandwich-like nanostructure can be used as anode material in lithium ion batteries, exhibiting remarkable capacities, outstanding rate capability, and cycling performances that are some of the best results among carbonaceous electrode materials and exceed most metal oxide-based anode materials derived from metal orgainc frameworks (MOFs). Apart from a high initial capacity of 1378 mAh g(-1) at 100 mA g(-1), this PNCs@Gr electrode can be cycled at high specific currents of 500 and 1000 mA g(-1) with very stable reversible capacities of 1070 and 948 mAh g(-1) to 100 and 200 cycles, respectively.