The Association between Circulating Lipids and Female Infertility Risk: A Univariable and Multivariable Mendelian Randomization Analysis.

Background: Although observational studies have demonstrated that blood lipids are associated with female infertility, the causality of this association remains unclear. We performed a univariable and multivariable Mendelian randomization (MR) analysis to evaluate the causal relationship between blood lipids and female infertility.

Methods: Single-nucleotide polymorphisms associated with lipid traits in univariate analysis were obtained from the Million Veteran Program (MVP) and Global Lipids Genetics Consortium (GLGC), involving up to 215,551 and 188,577 European individuals, respectively.

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.

Background: Long noncoding RNAs (lncRNAs) have driven research focused on their effects as oncogenes or tumor suppressors involved in carcinogenesis. However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear.

Methods: The expression of DLGAP1-AS2 was assessed by quantitative RT-PCR in multiple CRC cohorts.

EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis-related processes.

Extensive protein synthesis is necessary for uncontrolled cancer cell proliferation, requiring hyperactive ribosome biogenesis. Our previous Pan-cancer study has identified EXOSC8 as a potential copy number variation (CNV)-driven rRNA metabolism-related oncogene in colorectal cancer (CRC). Herein, we further investigated proliferation-prompting functions and mechanisms of EXOSC8 in CRC by performing in silico analyses and wet-lab experiments.

Long-Life Lithium-Metal All-Solid-State Batteries and Stable Li Plating Enabled by In Situ Formation of Li PS in the SEI Layer.

An ultrastable and kinetically favorable interface is constructed between sulfide-poly(ethylene oxide) (PEO) composite solid electrolytes (CSEs) and lithium metal, via in situ formation of a solid electrolyte interphase (SEI) layer containing Li PS . A specially designed sulfide, lithium polysulfidophosphate (LPS), can distribute uniformly in the PEO matrix via a simple stirring process because of its complete solubility in acetonitrile solvent, which is advantageous for creating a homogeneous SEI layer. The CSE/Li interface with high Li transportation capability is stabilized quickly through in situ formation of a Li PS /Li S/LiF layer via the reaction between LPS and lithium metal to inhibit lithium dendrite growth.

SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop.

Background: Small nucleolar RNA host gene (SNHG) long noncoding RNAs (lncRNAs) are frequently dysregulated in human cancers and involved in tumorigenesis and progression. SNHG17 has been reported as a candidate oncogene in several cancer types, however, its regulatory role in colorectal cancer (CRC) is unclear.

Methods: SNHG17 expression in multiple CRC cohorts was assessed by RT-qPCR or bioinformatic analyses.

Nanobody-Engineered Natural Killer Cell Conjugates for Solid Tumor Adoptive Immunotherapy.

Cancer immunotherapy based on natural killer (NK) cells is demonstrated to be a promising strategy. However, NK cells are deficient in ligands that target specific tumors, resulting in limited antitumor efficacy. Here, a glycoengineering approach to imitate the chimeric antigen receptor strategy and decorate NK cells with nanobodies to promote NK-based immunotherapy in solid tumors is proposed.

Immune checkpoint molecule TIGIT manipulates T cell dysfunction in septic patients.

Sepsis is a dysregulated host response to infection. T cell dysfunction results in the failure to eradicate pathogens and the increased susceptibility to nosocomial infections and mortality during sepsis. Although PD-1 has shown to be a promising target to interfere with T cells dysfunction, the role of other coinhibitory receptors in sepsis remains largely elusive.

Long noncoding RNA MCM3AP-AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR-193a-5p/SENP1.

Background: Accumulating evidences have shown that long noncoding RNAs (lncRNAs) play key roles in many diseases, including cancer. Several studies reported that MCM3AP antisense RNA 1 (MCM3AP-AS1) was associated with the tumorigenesis and progression. However, the specific function and mechanism of MCM3AP-AS1 in colorectal cancer (CRC) have not been fully understood.

Ternary flower-sphere-like MnO-graphite/reduced graphene oxide nanocomposites for supercapacitor.

Chemical fabrication of a nanocomposite structure for electrode materials to regulate the ion diffusion channels and charge transfer resistances and Faradaic active sites is a versatile strategy towards building a high-performance supercapacitor. Here, a new ternary flower-sphere-like nanocomposite MnO-graphite (MG)/reduced graphene oxide (RGO) was designed using the RGO as a coating for the MG. MnO-graphite (MnO-4) was obtained by KMnO oxidizing the pretreated graphite in an acidic medium (pH = 4).

Case Report: Prostate Adenocarcinoma With Mucinous Features of Normal-Level Serum PSA, Atypical Imaging, Biopsy-Negative, and Peculiar Urethrocystoscopic Manifestation.

Background: Mucinous tumors of the prostate are seen as rare morphological variants of prostate carcinoma. Misdiagnosis and missed diagnosis are frequent clinically, especially when the clinical performance appears atypical. Furthermore, there has not been reported about the urethrocystoscopic performance of mucinous adenocarcinoma growing into the prostatic urethra so far.

[Ectopic seminal tract opening in enlarged prostatic utricle: A report of 22 cases].

Objective: To explore the diagnosis, classification and treatment of ectopic seminal tract opening in enlarged prostatic utricle (EPU).

Methods: We retrospectively analyzed the clinical data on 22 cases of ectopic seminal tract opening in EPU confirmed by spermography, EPU open cannula angiography or intraoperative puncture of the vas deferens and treated by transurethral incision of EPU, cold-knife incision or electric incision of EPU, full drainage of the anteriorwal, and open or laparoscopic surgery from October 1985 to October 2017.

Results: Five of the patients were diagnosed with ectopic opening of the vas deferens and the other 17 with ectopic opening of the ejaculatory duct in EPU.

Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing.

Background: Sam68, an RNA-binding protein, exerts oncogenic functions in several types of cancer. However, the specific functions and mechanisms of Sam68 in colorectal cancer (CRC) had not been previously clarified. Pyruvate kinase muscle (PKM)2 is the key rate-limiting enzyme in glycolysis, and PKM2 maintains the glycolysis-dominant energy metabolism in most cancer cells.

[Expression of AXL enhances docetaxel-resistance of prostate cancer cells].

Objective: To explore the effect of the AXL expression on the chemosensitivity of prostate cancer PC-3 and DU145 cells to docetaxel and possible mechanisms.

Methods: Using Western blot, we examined the expressions of the AXL protein, p-AXL and Gas6 in the docetaxel-resistant PC-3 (PC-3-DR) and DU145 (DU145-DR) cells stimulated with gradually increased concentrations of docetaxel. We transfected the PC-3 and DU145 cells with negative NC ShRNA and AXL-ShRNA, respectively, which were confirmed to be effective, detected the proliferation, apoptosis and cycle distribution of the cells by CCK8, MTT and flow cytometry after treated with the AXL-inhibitor MP470 and/or docetaxel, and determined the expression of the ABCB1 protein in the PC-3-DR and DU145-DR cells after intervention with the AXL-inhibitor R428 and/or docetaxel.

Role of the functional variant (-652T>G) in the XRCC4 promoter in prostate cancer.

Several genes encoding DNA repair molecules have been proposed as cancer-susceptibility genes. Many studies have suggested that SNPs in XRCC4 could be implicated in altering the risk of prostate cancer (PCa). We examined the role of the functional variant (-652T>G) in the XRCC4 promoter in PCa.

Preparation and antibacterial property of silver-containing mesoporous 58S bioactive glass.

The modified mesoporous 58S bioglass (SM58S) was prepared through surface modification of the mesoporous 58S bioglass (M58S) with γ-aminopropyl triethoxysilane (KH550). The results of Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) showed that the amino groups were grafted to the surface of M58S after modification with KH550. The silver-containing SM58S (Ag-SM58S) and M58S (Ag-M58S) were prepared by the dipping method.

A novel integrated biosensor based on co-immobilizing the mediator and microorganism for water biotoxicity assay.

A novel integrated biosensor for biotoxicity assay has been developed by co-immobilizing microorganisms and mediators within a novel redox hydrogel. The proposed redox hydrogel acts as an immobilizing matrix both for microorganism E. coli and redox mediator, which was prepared by grafting the benzoquinone (BQ) redox mediator with gelatin/silica hybrid hydrogel (GSH).

[Composition and morphology of stones in enlarged prostatic utricle].

Objective: To investigate the composition and morphology of the stones in the enlarged prostatic utricle (EPU).

Methods: We took out 36 EPU stones from 11 patients by transurethral fenestration between 1992 and 2011, and analyzed the stones by scanning electron microscopy, x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIS).

Results: Under the scanning electron microscope, all the EPU stones were constituted of many intensive minicrystals and amorphous matrix.

[TRAIL gene polymorphism and genetic susceptibility to prostate cancer in the Chinese Han population of Nanjing].

Objective: To investigate the correlation between the polymorphism of the tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and the genetic susceptibility to prostate cancer (PCa) in the Chinese Han population in Nanjing.

Methods: We performed a case control study on 187 cases of PCa and 237 cancer-free healthy controls. Peripheral blood genome DNA was extracted from the subjects for analysis of the polymorphism of the TRAIL-716 locus by polymerase chain reaction-ligase detection reaction (PCR-LDR).

A functional polymorphism in MSMB gene promoter is associated with prostate cancer risk and serum MSMB expression.

Background: To explore the reported association of SNP marker rs10993994 with prostate cancer identified by two independent in two genome-wide association studies (GWAS) further, we performed a case-control study in southern Chinese Han population. Consequently, we detected the serum levels of MSMB expression with different genotypes in the cases and controls to characterize the functional consequences of rs10993994.

Materials And Methods: Two hundred fifty-one prostate cancer and 258 control subjects were included in the cancer association study and 90 serum samples were used to test the expression of the MSMB by Enzyme-linked immunosorbent assay (ELISA).

VEGFA +936C>T polymorphism and cancer risk: a meta-analysis.

Vascular endothelial growth factor A (VEGF-A), a major driver of physiological and pathological angiogenesis, plays important roles in the etiology and metastasis of cancers. The +936C>T polymorphism in the 3'-untranslated region of the VEGFA gene has been implicated in cancer risk and is related to VEGF-A protein production; however, published data have been conflicting. To derive a more precise estimation of the relationship, a meta-analysis was performed of 13,293 cancer cases and 12,308 control subjects from 29 published case-control studies.

(Z)-N-[3-(4-Bromo-benzo-yl)-1,3-thia-zolidin-2-yl-idene]cyanamide.

In the title compound, C(11)H(8)BrN(3)OS, the dihedral angle between the benzene and thia-zolidine rings is 63.4 (2)°. Inter-molecular C-H⋯N inter-actions help to stabilize the crystal structure.

(E)-1-(1H-Benzotriazol-1-yl 3-oxide)-3-methoxy-but-2-en-1-one.

The title compound, C(11)H(11)N(3)O(3), crystallizes with two independent mol-ecules of similar geometry in the asymmetric unit. The mol-ecular conformations are stabilized by intra-molecular C-H⋯O hydrogen bonds. The crystal packing consists of wave-like layers parallel to the bc plane formed by inter-molecular C-H⋯O hydrogen-bonding inter-actions involving only one independent mol-ecule.

5-Phenyl-7,8-dihydro-1,3-dioxano[4,5-g]isoquinoline.

In the title compound, C(16)H(13)NO(2), the two benzene rings make a dihedral angle of 55.5 (2)°. The crystal packing is stabilized by inter-molecular C-H⋯O hydrogen bonds and weak π-π stacking inter-actions [centroid-centroid distance = 3.

7-Nitro-quinazolin-4(3H)-one.

In the crystal structure of the title compound, C(8)H(5)N(3)O(3), inter-molecular N-H⋯O hydrogen bonds link mol-ecules into centrosymmetric dimers. These dimers are, in turn, linked though weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonds and π-π stacking inter-actions, with centroid-centroid distances of 3.678 (3) Å, into a three-dimensional network.