Publications by authors named "JiuCheng Shi"
Presenilin 1 Is a Therapeutic Target in Pulmonary Hypertension and Promotes Vascular Remodeling.
Am J Respir Cell Mol Biol
June 2024
Small muscular pulmonary artery remodeling is a dominant feature of pulmonary arterial hypertension (PAH). PSEN1 affects angiogenesis, cancer, and Alzheimer's disease. We aimed to determine the role of PSEN1 in the pathogenesis of vascular remodeling in pulmonary hypertension (PH).
View Article and Find Full Text PDF15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol
September 2015
Article Synopsis
- Pulmonary arterial hypertension (PAH) is a serious condition involving thickened artery walls, increased resistance, and right heart failure; recent research highlights the role of 15-lipoxygenase (15-LO) and its product, 15-hydroxyeicosatetraenoic acid (15-HETE), in PAH effects on arterial walls.
- Studies in experimental models show that both hypoxia and Sugen 5416 exposure lead to increased platelet deposition in the lungs, which can be blocked by a 15-LO inhibitor called nordihydroguaiaretic acid (NDGA).
- The 15-LO and 15-HETE signaling pathways contribute to endothelial dysfunction and platelet activation in hypoxia, with
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by pulmonary vascular obstruction due in part to excessive pulmonary artery endothelial cells (PAECs) migration and proliferation. The mitochondrial fission protein dynamin-related protein-1 (DRP1) has important influence on pulmonary vascular remodeling. However, whether DRP1 participates in the development and progression of pulmonary vascular angiogenesis has not been reported previously.
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