Publications by authors named "Jiu-Ying Sun"
Article Synopsis
- Pseudorabies (PR) is an infectious disease caused by the pseudorabies virus (PRV), and this study focused on detecting and analyzing the recent outbreaks of genotype II PRV.
- Researchers isolated brain tissues suspected of PRV infection, sequenced the virulence-related genes, and conducted pathogenicity evaluations using mice and piglets.
- The isolated strain, named PRV TJbd2023, showed high pathogenicity, causing severe symptoms and a 66.7% mortality rate in suckling piglets, indicating it may be linked to recent outbreaks and vaccine failures in Tianjin, China.
Novel β1,4 N-acetylglucosaminyltransferase in de novo enzymatic synthesis of hyaluronic acid oligosaccharides.
Appl Microbiol Biotechnol
August 2023
The efficiency of de novo synthesis of hyaluronic acid (HA) using Pasteurella multocida hyaluronate synthase (PmHAS) is limited by its low catalytic activity during the initial reaction steps when monosaccharides are the acceptor substrates. In this study, we identified and characterized a β-1,4-N-acetylglucosaminyl-transferase (EcGnT) derived from the O-antigen gene synthesis cluster of Escherichia coli O8:K48:H9. Recombinant β1,4 EcGnT effectively catalyzed the production of HA disaccharides when the glucuronic acid monosaccharide derivative 4-nitrophenyl-β-D-glucuronide (GlcA-pNP) was used as the acceptor.
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