Publications by authors named "Jiu-Yang Ding"
DNA methylation modifications are an important mechanism affecting the process of atherosclerosis (AS). Previous studies have shown that Galectin-8 (GAL8) DNA methylation level is associated with sudden death of coronary heart disease or acute events of coronary heart disease. However, the mechanism of GAL8 DNA methylation and gene expression in AS has not been elucidated, prompting us to carry out further research on it.
View Article and Find Full Text PDFArticle Synopsis
- Methamphetamine (METH) is an illegal stimulant linked to an increased risk of neurodegenerative disorders like Parkinson's disease due to its effect on alpha-synuclein (α-syn) aggregation.
- The study investigates how high doses of METH influence the SUMOylation of α-syn by measuring various related markers in human neuroblastoma cells, mouse neurons, and METH-exposed mouse brain tissues.
- Results indicate that while METH increases α-syn and SUMO-1 expression, it actually reduces the SUMOylation levels of α-syn, potentially due to decreased UBC9 levels; altering SUMOylation impacts α-syn aggregation induced by METH.