Maternal mitochondrial function affects paternal mitochondrial inheritance in Drosophila.

The maternal inheritance of mitochondria is a widely accepted paradigm, and mechanisms that prevent paternal mitochondria transmission to offspring during spermatogenesis and postfertilization have been described. Although certain species do retain paternal mitochondria, the factors affecting paternal mitochondria inheritance in these cases are unclear. More importantly, the evolutionary benefit of retaining paternal mitochondria and their ultimate fate are unknown.

Causal associations of anthropometric measurements with osteoarthritis: A Mendelian randomization study.

Objective: We believe that there is a causal relationship between waist circumference and knee osteoarthritis. To confirm the hypothesis, we have conducted this study.

Methods: Genetic variants associated with the five anthropometric variables were obtained from previous large-scale genomewide association studies.

Cardiovascular risk factors mediating the protective effect of education on cervical spondylosis risk.

The causal association between education and cervical spondylosis may be mediated partly through risk factors of cardiovascular disease. The identification of the protective effect of education and the evaluation of risk factors will help to optimize disease prevention at both clinical and public health levels. In this study, we applied several different Mendelian randomization (MR) methods to identify which cardiovascular factors underlie the clustering of cervical spondylosis with cardiovascular disease, and the degree to which these mediate an effect of education.

Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma.

Background: Colorectal cancer (CRC), ranking third in cancer prevalence and second in mortality worldwide, is mainly derived from colorectal adenoma (CRA). CRA is a common benign disease in the intestine with rapidly increasing incidence and malignant potential. Therefore, this study aimed to recognize significant biomarkers and original pathogenesis in CRA.

Effective natural inhibitors targeting granzyme B in rheumatoid arthritis by computational study.

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, and current treatments for RA fall short of the outcomes expected by clinicians and patients.

Objectives: This study aimed to identify novel therapeutic and prognostic targets in RA at the genomic level and to screen desirable compounds with potential inhibitory effects on GZMB.

Methods: We performed differential gene analysis on GSE55235 and GSE55457 from Gene Expression Omnibus (GEO) and then obtained the intersection of the two differentially expressed genes (DEGs) lists by drawing Venn diagrams.

The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases.

Psoriasis is more common in patients with inflammatory bowel disease (IBD) than in the general population. Similarly, patients with psoriasis or psoriatic arthritis (PsA) have a higher incidence of IBD. However, whether this association is causal remains unknown.

Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis.

Background: Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing number of studies have investigated the relationship between sepsis and pyroptosis.

Social Group Differences in Influencing Factors for Chinese Urban Residents' Subjective Well-Being: From the Perspective of Social Stratification.

With the great pressure of modern social life, the problem of residents' subjective well-being has attracted scholars' attention. Against the background of institutional transformation, China has a special social stratification structure. The socio-economic resources and living needs of different social classes are different, resulting in differences in the level of subjective well-being and the influencing factors for this.

Minimally Invasive Percutaneous TightRope® System Fixation for an Unstable Posterior Pelvic Ring: Clinical Follow-up and Biomechanical Studies.

Objective: To evaluate the mechanical stability and clinical efficacy of minimally invasive percutaneous TightRope® systems applied via gun-shaped reduction forceps for unstable posterior pelvic ring fractures.

Materials And Methods: This study consists of two parts: a clinical retrospective study and a randomized controlled biomechanical test. For the clinical study, a retrospective analysis of posterior pelvic ring fractures was performed between June 2015 and May 2020.

Fracture risks in patients with atrial fibrillation treated with different oral anticoagulants: a meta-analysis and systematic review.

Aims: evidence on the difference in fracture risks for patients with atrial fibrillation (AF) receiving direct oral anticoagulants (DOACs) versus warfarin remains controversial. We aim to compare the fracture risks between the DOAC and warfarin prescriptions among the AF patients.

Methods And Results: we systematically searched PubMed, EMBASE, the Cochrane Library and Web of Science up to 19 April 2021 for relevant studies.

Polydopamine-assisted decoration of Se nanoparticles on curcumin-incorporated nanofiber matrices for localized synergistic tumor-wound therapy.

The management of surgical wounds incurred during tumor removal procedures has become a non-negligible issue. Herein, for the first time, an implantable polymer-based nanofiber matrix is developed for postoperative tumor management by promoting wound healing and preventing cancer recurrence. The multifunctional matrix is successfully prepared by assembling chitosan-stabilized Se nanoparticles (SeNPs) at the surface of polydopamine (PDA) modified poly(ε-caprolactone)/curcumin fibres (PCL/CUR), denoted as PCL/CUR/PDA@Se.

Brachial muscle injury resulting in acute compartment syndrome of the upper arm: a case report and literature review.

Background: Acute compartment syndrome (ACS) is a potentially devastating condition. ACS is rare in the upper arm.

Case Presentation: We report a case of acute compartment syndrome of the anterior compartment of the upper arm due to brachial muscle injury.

Influence of swimming exercise on the expression of apoptotic gene caspase-3 in chondrocytes in osteoarthritis.

Objective: To study swimming exercise's effect on caspase-3 expression in chondrocytes in osteoarthritis (OA).

Methods: 36 SD rats were randomly separated into normal group (n = 12), OA model group (n = 12) and swimming exercise group (n = 12). After modeling, rats received no intervention in model group and swimming exercise once a day (15 min/time) for 4 consecutive weeks in swimming exercise group.

tsRBase: a comprehensive database for expression and function of tsRNAs in multiple species.

tRNA-derived small RNAs (tsRNAs) are a class of novel small RNAs, ubiquitously present in prokaryotes and eukaryotes. It has been reported that tsRNAs exhibit spatiotemporal expression patterns and can function as regulatory molecules in many biological processes. Current tsRNA databases only cover limited organisms and ignore tsRNA functional characteristics.

Polydopamine regulated hydroxyapatite microspheres grown in the three-dimensional honeycomb-like mollusk shell-derived organic template for osteogenesis.

Layered osteochondral composite scaffolds are considered as a promising strategy for the treatment of osteochondral defects. However, the insufficient osseous support and integration of the subchondral bone layer frequently result in the failure of osteochondral repair. Therefore, it is essentially important to explore new subchondral bone constructs tailored to support bone integration and healing.

Analysis of Colorectal Cancer-Associated Alternative Splicing Based on Transcriptome.

Colorectal cancer (CRC) is a severe risk to public health, and there is growing evidence that alternative splicing (AS) plays a crucial role in cancer. However, the AS biomarkers in CRC are seldom reported. In this study, we perform transcriptome analysis of colorectal samples for cancer-specific AS and transcriptomic alterations.

Engineered Zinc Titanate Coatings on the Titanium Surface with Enhanced Antitumor Properties and Biocompatibility.

Surgical treatment of osteosarcoma is usually difficult to radically eliminate cancer cells, and it will concomitantly result in bone defects with varied sizes. To prevent tumor recurrence and reconstruction of the bone defect, there is a pressing need to develop suitable implants that have anticancer capability while promoting the regeneration of bone tissues. Here, we first report the design and fabrication of titanium-based implants engineered with a series of alveolate double-layered zinc titanate nanogridding coatings (NG-Zn0.

Transcriptome Analysis Identifies Piwi-Interacting RNAs as Prognostic Markers for Recurrence of Prostate Cancer.

Prostate cancer remains the second leading cause of male cancer death, and there is an unmet need for biomarkers to identify patients with such aggressive disease. Piwi-inteacting RNAs (piRNAs) have been classified as transcriptional and posttranscriptional regulators in somatic cells. In this study, we discovered three piRNAs as novel prognostic markers and their association with prostate cancer biochemical recurrence was confirmed in validation data set.

Fabrication of Curcumin-Modified TiO Nanoarrays via Cyclodextrin Based Polymer Functional Coatings for Osteosarcoma Therapy.

The incomplete removal of bone tumors leads to increased local recurrence and poor prognosis. To prevent ostoperative tumor recurrence and simultaneously repair surgery-caused bone defects, there is a need of great significance to develop implantable biomaterials possessing both cancer cell-killing ability and excellent bioactivity. In this work, a functionalized titanium-based implant is successfully fabricated by loading curcumin (CUR) onto cyclodextrin based polymer (pCD) modified titanium dioxide (TiO ) nanorod arrays.

Antagonistic effect of vitamin E on nAlO-induced exacerbation of Th2 and Th17-mediated allergic asthma via oxidative stress.

Some basic research has shown that nanomaterials can aggravate allergic asthma. However, its potential mechanism is insufficient. Based on the research that alumina nanopowder (nAlO) has been reported to cause lung tissue damage, the purpose of this study was to explore the relationship between nAlO and allergic asthma as well as its molecular mechanism.

Single Fe Atom on Hierarchically Porous S, N-Codoped Nanocarbon Derived from Porphyra Enable Boosted Oxygen Catalysis for Rechargeable Zn-Air Batteries.

Iron-nitrogen-carbon materials (Fe-N-C) are known for their excellent oxygen reduction reaction (ORR) performance. Unfortunately, they generally show a laggard oxygen evolution reaction (OER) activity, which results in a lethargic charging performance in rechargeable Zn-air batteries. Here porous S-doped Fe-N-C nanosheets are innovatively synthesized utilizing a scalable FeCl -encapsulated-porphyra precursor pyrolysis strategy.

Anterolateral tibial plateau osteotomy as a new approach for the treatment of posterolateral tibial plateau fracture: A case report.

Rationale: It is challenging to visualize and reduce a posterolateral tibial plateau fracture through an anterolateral approach as the tibial plateau fragments are often covered by the fibular head and ligamentous structures.

Patient Concerns: In this case report, we describe a patient with a depression fracture of the posterolateral quadrant combined with a split fracture of the posteromedial quadrant and an avulsion fracture of the tibial intercondylar eminence.

Diagnoses: Tibial plateau fracture(AO type 41-B3).

Reconstruction of acetabular posterior wall fractures with extension to the roof using dual arc-shaped plates: A case report.

Anatomical reduction and rigid fixation of acetabular posterior wall fractures extending to the acetabular roof proves challenging because of the big bony fragment and muscular obstruction to accessing this region. This report describes a novel reconstructive technique in a patient with an acetabular posterior wall fracture involving the acetabular roof. Both the standard Kocher-Langenbeck approach and a greater trochanter osteotomy technique were used.