Publications by authors named "Jitian He"
Article Synopsis
- Group 1 innate lymphoid cells (ILCs), which include natural killer (cNK) cells and ILC1s, play a key role in both directly killing target cells and regulating the immune environment in the liver, especially in the context of liver tumors.
- The research utilized a specific mouse model to demonstrate how certain transcription factors (like Prdm1) influence the development and function of these immune cells, revealing that although they don't affect cNK cell killing ability, their absence can lead to increased cancer metastasis.
- Findings highlight that Prdm1 is crucial for maintaining functional aspects of cNK cells and ILC1s and their communication with other immune cells, suggesting its potential as a target for new immune therapies against
The advent of Induced Pluripotent Stem Cells (iPSCs) has revolutionized neuroscience research. This groundbreaking innovation has facilitated the development of three-dimensional (3D) neural organoids, which closely mimicked the intricate structure and diverse functions of the human brain, providing an unprecedented platform for the in-depth study and understanding of neurological phenomena. However, these organoids lack key components of the neural microenvironment, particularly immune cells like microglia, thereby limiting their applicability in neuroinflammation research.
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