Publications by authors named "Jithin Sam Varghese"

Article Synopsis
  • The study aimed to understand factors affecting care and progression to severe eye conditions in U.S. diabetes patients with newly detected mild to moderate nonproliferative diabetic retinopathy (NPDR) without diabetic macular edema (DME).
  • Researchers analyzed electronic health records from 2015 to 2023, focusing on urban vs. rural residence, race and ethnicity, and glycemic control in relation to receipt of guideline-recommended care and progression to vision-threatening diabetic retinopathy (VTDR).
  • Results showed that only 40% of patients received proper care, with 14% progressing to VTDR; urban residents and racial/ethnic minorities were impacted, and poor glycemic control hindered care and increased progression
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Background: Accurate assessment of body composition during infancy is an important marker of early growth. This study aimed to develop anthropometric models to predict body composition in 3-24-month-old infants from diverse socioeconomic settings and ethnic groups.

Methods: An observational, longitudinal, prospective, multi-country study of infants from 3 to 24 months with body composition assessed at three monthly intervals using deuterium dilution (DD) and anthropometry.

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Background: Studies of new-onset diabetes as a post-acute sequela of SARS-CoV-2 infection are difficult to generalize to all socio-demographic subgroups.

Objective: To study the risk of new-onset diabetes after SARS-CoV-2 infection in a socio-demographically diverse sample.

Design: Retrospective cohort study of electronic health record (EHR) data available from the OneFlorida + clinical research network within the National Patient-Centered Clinical Research Network (PCORnet).

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Article Synopsis
  • The study aimed to analyze changes in body mass index (BMI) among individuals aged 18-99 years with and without a SARS-CoV-2 infection using data from the OneFlorida+ Clinical Research Network.
  • It involved 249,743 participants, with the Exposed cohort (those positive for SARS-CoV-2) having a slightly higher average BMI at the start, while the Unexposed cohort (negative tests) experienced a decrease in BMI over 100 days.
  • The findings showed that while the Exposed cohort's BMI remained stable, the Unexposed cohort's decreased slightly, and the Historical cohort's increased, with variations noted across different sex, race, and age subgroups.
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Aims: To characterize the risk of falls among males and females by joint glycemic, blood pressure (BP) and cholesterol control among older adults (≥65 years) with diagnosed diabetes in USA.

Methods: Using longitudinal data from the Health and Retirement Study (2006-2019), we studied the association of joint glycemic (HbA1c < 7.5 %), BP (systolic <140 and diastolic <90 mmHg) and cholesterol (total < 200 mg/dL) control with two-year risk of falls.

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Article Synopsis
  • Professional guidelines advise reaching specific targets for blood sugar, blood pressure, and cholesterol to prevent complications from diabetes, with the WHO recommending countries monitor these targets.
  • The case of India highlights the challenges faced in establishing a reliable diabetes surveillance system, despite government efforts like the National Programme for Prevention and Control of Non-Communicable Diseases.
  • An integrated framework for data collection and analysis is suggested to improve local decision-making, combining insights from various surveys and health records to enhance diabetes management and compare outcomes across regions.
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Mounting evidence demonstrates that intimate partners sharing risk factors have similar propensities for chronic conditions such as hypertension. The objective was to study whether spousal hypertension was associated with one's own hypertension status independent of known risk factors, and stratified by socio-demographic subgroups (age, sex, wealth quintile, caste endogamy). Data were from heterosexual married couples (n = 50,023, women: 18-49 years, men: 21-54 years) who participated in the National Family Health Survey-V (2019-2021).

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Aims: To estimate the proportion of people with self-reported diabetes receiving eye and foot examinations in Latin America and the Caribbean (LAC).

Methods: Cross-sectional analysis of national health surveys in nine countries. Adults aged 25-64 years with self-reported diabetes.

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Objective: To study body mass index (BMI) changes among individuals aged 18-99 years with and without SARS-CoV-2 infection.

Subjects/methods: Using real-world data from the OneFlorida+ Clinical Research Network of the National Patient-Centered Clinical Research Network, we compared changes over time in BMI in an Exposed cohort (positive SARS-CoV-2 test between March 2020 - January 2022), to a contemporary Unexposed cohort (negative SARS-CoV-2 tests), and an age/sex-matched Historical control cohort (March 2018 - January 2020). Body mass index (kg/m) was retrieved from objective measures of height and weight in electronic health records.

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Mounting evidence demonstrates that intimate partners sharing risk factors have similar propensities for chronic conditions such as hypertension. The objective was to study whether spousal hypertension was associated with one's own hypertension status independent of known risk factors, and stratified by socio-demographic subgroups (age, sex, wealth quintile, caste endogamy). Data were from heterosexual married couples (n = 50,023, women: 18-49y, men: 21-54y) who participated in the National Family Health Survey-V (2019-21).

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Heterosexual couples in romantic relationships are known to influence each other's hypertension risk. However, the role of partners on an individual's hypertension status in same-sex relationships is less understood. Our objective is to characterize the burden of high blood pressure among middle-aged and older couples consisting of men who have sex with men (MSM) and women who have sex with women (WSW) living in the US.

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Background: Health concordance within couples presents a promising opportunity to design interventions for disease management, including hypertension. We compared the concordance of prevalent hypertension within middle-aged and older heterosexual couples in the United States, England, China, and India.

Methods And Results: Cross-sectional dyadic data on heterosexual couples were used from contemporaneous waves of the HRS (US Health and Retirement Study, 2016/17, n=3989 couples), ELSA (English Longitudinal Study on Aging, 2016/17, n=1086), CHARLS (China Health and Retirement Longitudinal Study, 2015/16, n=6514), and LASI (Longitudinal Aging Study in India, 2017/19, n=22 389).

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Importance: Hypertension is a major cause of morbidity and mortality worldwide. Previous efforts to characterize gaps in the hypertension care continuum-including diagnosis, treatment, and control-in India did not assess district-level variation. Local data are critical for planning, implementation, and monitoring efforts to curb the burden of hypertension.

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Importance: Diabetes is widespread and treatable, but little is known about the diabetes care continuum (diagnosis, treatment, and control) in India and how it varies at the national, state, and district levels.

Objective: To estimate the adult population levels of diabetes diagnosis, treatment, and control in India at national, state, and district levels and by sociodemographic characteristics.

Design, Setting, And Participants: In this cross-sectional, nationally representative survey study from 2019 to 2021, adults in India from 28 states, 8 union territories, and 707 districts were surveyed for India's Fifth National Family Health Survey (NFHS-5).

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Indian people are at high risk for type 2 diabetes (T2DM) even at younger ages and lower body weights. Already 74 million people in India have the disease, and the proportion of those with T2DM is increasing across all strata of society. Unique aspects, related to lower insulin secretion or function, and higher hepatic fat deposition, accompanied by the rise in overweight (related to lifestyle changes) may all be responsible for this unrelenting epidemic of T2DM.

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Article Synopsis
  • The study investigates the link between early nutrition, specifically protein-energy supplementation, and mental health outcomes in adulthood among individuals in Guatemala, highlighting a significant issue of undernutrition in low- and middle-income countries.
  • It analyzes data from 1249 participants who received different types of nutritional supplements in their early years and assesses their mental distress in adulthood using standardized measures.
  • Findings indicate that both partial and full protein-energy supplementation during the first 1000 days significantly reduced the chances of mental distress later in life, regardless of sex, and the results remained consistent even when controlling for various life factors.
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Background: Bacterial sepsis is associated with significant morbidity and mortality. However, to date, there is no single test that predicts sepsis with reproducible results. We proposed that using a combination of clinical and laboratory parameters and a novel biomarker, plasma neutrophil gelatinase-associated lipocalin (NGAL) may aid in early diagnosis.

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Background: Subjective social status (SSS, perception of social position relative to a frame of reference) has been associated with physical, mental and socio-emotional wellbeing. However, these associations may be susceptible to unmeasured confounding by life course objective socio-economic position (SEP; such as wealth, education and employment) and life satisfaction.

Purpose: To estimate the association of position on ladders of perceived community respect and perceived economic status with weight, distress and wellbeing, independent of objective SEP in cohorts from three low and middle-income countries.

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Objectives: We evaluated changes in priority indicators of child growth from 2006 to 2021 and examined the role of human development measures in these changes.

Methods: We estimated cumulative and annualized changes in state- and district-level child growth indicators using 3 rounds of National Family Health Surveys (2005-2006, 2015-2016, 2019-2021) in 36 states. Outcomes included stunting, underweight, wasting, and overweight.

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Temporally harmonized asset indices allow the study of changes in relative wealth (mean, variance, social mobility) over time and its association with adult health and human capital in cohort studies. Conditional measures are the unexplained residuals of an indicator regressed on its past values. Using such measures, previously used to study the relative importance of key life stages for anthropometric growth, we can identify specific life stages during which changes in relative wealth are important for adult health in longitudinal studies.

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Several international studies have stratified people with diabetes into phenotypical clusters. However, there has not been a systematic examination of the variation in these clusters across ethnic groups. For example, some clusters appear more frequent among Asians and may have lower weight, age at diagnosis and poorer beta cell function.

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Background: Parity has been associated with both short- and long-term weight gain in women. However, it is not clear if timing of parity across the reproductive age has different associations with BMI.

Methods: To prospectively assess the association between age at childbirth and maternal change in BMI, we analyzed data from the ongoing INCAP Longitudinal Study, which started in 1969 in four villages in Guatemala.

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Background: The prevalence of mental health concerns is growing worldwide, along with lack of access to and receipt of needed treatment. Current gaps in treatment provision have led to exploring alternative methods of prevention, with research linking nutrition and mental health, of particular relevance in low- and middle-income countries, with a high prevalence of undernutrition.

Objectives: To examine whether exposure to a protein-energy nutritional supplement during the first 1000 d of life decreased odds of mental distress in adulthood among men and women in Guatemala compared with receiving a low energy-no protein supplement or supplementation outside the 1000-d window.

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