Axial ligand-induced high electrocatalytic hydrogen evolution activity of molecular cobaloximes in homo- and heterogeneous medium.

Three new molecular cobaloxime complexes with the general formula [ClCo(dpgH)L] (1-3), where L1 = -(4-pyridylmethyl)-1,8-naphthalimide, L2 = 4-bromo--(4-pyridylmethyl)-1,8-naphthalimide, L3 = 4-piperidin--(4-pyridylmethyl)-1,8-naphthalimide, have been synthesized and characterized by UV-Vis, multinuclear NMR, FT-IR and PXRD spectroscopic techniques. The crystal structures of all complexes have also been reported. The electrocatalytic activity of complexes is investigated under two catalysis conditions: (i) homogeneous conditions in acetonitrile using acetic acid (AcOH) as a proton source and (ii) heterogeneous conditions upon immobilization onto the surface of activated carbon cloth (CC).

Atypical Presentation of Posterior Reversible Encephalopathy Syndrome (PRES): A Case Report and Review of the Literature.

Posterior reversible encephalopathy syndrome (PRES) is a reversible clinico-radiological entity characterized by acute neurological symptoms and white matter vasogenic edema that commonly affects the posterior occipital and parietal lobes of the brain. Patients with this condition usually present with complaints of headache, encephalopathy, seizures, or visual disturbances. Nystagmus and periodic alternating gaze are rarely reported presentations of PRES patients.

Primary polycythaemia: A neglected risk factor.

In this case series, we report a 32-year-old male patient with myocardial infarction and 45-year-old female with portal vein thrombosis with splenic infarcts, which were the initial manifestations of polycythaemia vera. The awareness of myeloproliferative disorders as a possible underlying disease-especially in young patients presenting with myocardial infarction and portal venous thrombosis-is crucial for clinical management, as a missed diagnosis can worsen the patients' further prognosis.

Aluminum-air batteries: current advances and promises with future directions.

Owing to their attractive energy density of about 8.1 kW h kg and specific capacity of about 2.9 A h g, aluminum-air (Al-air) batteries have become the focus of research.

A Review on the Effect of Metal Oxide Nanoparticles on Tribological Properties of Biolubricants.

This review provides a comprehensive and accessible literature review on the integration of nanoparticles into biolubricants to enhance wear and friction regulation, thus improving the overall lubricated system performance. Nanotechnology has significantly impacted various industries, particularly in lubrication. Nanobiolubricants offer promising avenues for enhancing tribological properties.

Bibliometric review of telematics-based automobile insurance: Mapping the landscape of research and knowledge.

Telematics technology and its implementation in auto insurance have received great interest due to their potential to transform the insurance sector and promote safer driving practices. By implementing telematics technology, insurers may tailor insurance premiums to individual drivers, taking into account their real driving habits and performance, ultimately leading to improved road safety, cost savings, and an empowered driving community. The current study, through bibliometric analysis, carefully identifies and evaluates the existing body of scholarly literature on this subject for the last 21 years, including journal articles, conference papers, and related publications.

Intraconal Retroorbital Cavernous Hemangioma - A Case Report.

Unlabelled: Cavernous hemangioma of orbit is a benign, noninfiltrative, slowly progressive vascular neoplasm. It is usually asymptomatic but patients may present with proptosis and diminished vision due to compression of second cranial nerve, optic nerve. This can be usually diagnosed with the help of clinical examination and computed tomography (CT) or magnetic resonance imaging (MRI).

Homoleptic Ni(II) dithiocarbamate complexes as pre-catalysts for the electrocatalytic oxygen evolution reaction.

Four new functionalized Ni(II) dithiocarbamate complexes of the formula (1-4) (L = -methylthiophene--3-pyridylmethyl dithiocarbamate, L = -methylthiophene--4-pyridylmethyl dithiocarbamate, L = -benzyl--3-pyridylmethyl dithiocarbamate, and L = -benzyl--4-pyridylmethyl dithiocarbamate) have been synthesized and characterized by IR, UV-vis, and H and C{H} NMR spectroscopic techniques. The solid-state structure of complex 1 has also been determined by single crystal X-ray crystallography. Single crystal X-ray analysis revealed a monomeric centrosymmetric structure for complex 1 in which two dithiocarbamate ligands are bonded to the Ni(II) metal ion in a S^S chelating mode resulting in a square planar geometry around the nickel center.

A Recent Update: Solid Lipid Nanoparticles for Effective Drug Delivery.

Solid lipid nanoparticles (SLNs) are one of the developed technologies for addressing the bioavailability and targeting issues of drug delivery. In this review article, we attempted to incorporate all the essential details of SLNs like various methods of preparation, different models of SLNs, updated characterization methods, in vivo behavior (uptake), their applications, route of administration as well as advancements taken place in the field of delivery of biological drugs like gene vector, new adjuvant for vaccines, protein, and peptide with SLNs. Surface modified SLNs hold excellent potential for targeted and controlled drug delivery which is discussed and summarized.

Challenges and Recent Advances of Novel Chemical Inhibitors in Medulloblastoma Therapy.

Medulloblastoma is a common term used for the juvenile malignant brain tumor, and its treatment is exciting due to different genetic origins, improper transportation of drug across the blood-brain barrier, and chemo-resistance with various side effects. Currently, medulloblastoma divided into four significant subsections (Wnt, Shh, Group 3, and Group 4) is based on their hereditary modulation and histopathological advancement. In this chapter, we tried to combine several novel chemical therapeutic agents active toward medulloblastoma therapy.

Carbon nanotubes ornamented hollow polymethyl methacrylate microspheres for turbidity removal from water.

Novel materials with low density are being synthesized with great interest owing to their effectiveness in water purification systems. Materials of micro/nano-scale provide outstanding results in miniature point-of-use devices because of their high surface-to-volume ratio. In this study, we report the successful synthesis of hollow polymethyl methacrylate microspheres (HPM) coated with functionalized carbon nanotubes (f-CNTs) (CHPM) by employing solvent evaporation and in situ coating techniques.

A comprehensive review on possibilities of treating psoriasis using dermal cyclosporine.

Psoriasis is an autoimmune, chronic proliferative, inflammatory skin disease with high comorbidity. Psoriasis is not a curable disease; it can only be managed. Cyclosporine A (CyA) is one of the FDA-approved immunosuppressant drug used in severe Psoriasis.

Biotite as a geoindicator of rare earth element contamination in Gomati River Basin, Ganga Alluvial Plain, northern India.

Rare earth elements (REE) are emerging as modern high-technology-related novel micro-contaminants in freshwater aquatic systems and are therefore attracting global attention due to their potential human health risks. The Gomati River (a tributary of the Ganga River) sediments were analyzed for REE concentrations to establish REE contamination and to identify biotite mica mineral as a geoindicator. Chondrite-normalized REE pattern of the river sediments and biotite mica mineral were similar and depict a strong light REE (LREE) enrichment and relatively flatter heavy REE (HREE).

A Review on Recent Trends in Green Synthesis of Gold Nanoparticles for Tuberculosis.

Tuberculosis (TB) is a contagious disease that has affected mankind. The anti-TB treatment has been used from ancient times to control symptoms of this disease but these medications produced some serious side effects. Herbal products have been successfully used for the treatment of TB.

Efficient -formylation of primary aromatic amines using novel solid acid magnetic nanocatalyst.

Sulfonic acid functionalized over biguanidine fabricated silica-coated heterogeneous magnetic nanoparticles (NP@SOH) have been synthesized, well characterized and explored for the first time, as an efficient and recyclable catalyst for -formylation of primary amines under mild reaction conditions. Exploiting the magnetic nature of FeO, the prepared catalyst was readily recovered from the reaction mixture an external magnet. The catalyst can be reused for up to six cycles without any substantial loss of catalytic activity.

Insights into the interaction of potent antimicrobial chalcone triazole analogs with human serum albumin: spectroscopy and molecular docking approaches.

Mechanistic insights into the interaction of five previously chemically synthesized triazole-linked chalcone analogs (CTs) with human serum albumin (HSA) were sought using various spectroscopic techniques (UV-visible absorption, fluorescence, and circular dichroism) and molecular docking. The fluorescence quenching experiments performed at three different temperatures (288, 298 and 308 K) revealed the static mode of quenching and the binding constants ( ∼ 10) obtained indicated the strong affinity of these analogs for HSA. Furthermore, significant changes in the secondary structure of HSA in the presence of these analogs were also confirmed by far UV-CD spectroscopy.

Whole Genome Sequencing of Clinical Isolates From India Reveals Genetic Heterogeneity and Region-Specific Variations That Might Affect Drug Susceptibility.

Whole genome sequencing (WGS) of has been constructive in understanding its evolution, genetic diversity and the mechanisms involved in drug resistance. A large number of sequencing efforts from across the globe have revealed genetic diversity among clinical isolates and the genetic determinants for their resistance to anti-tubercular drugs. Considering the high TB burden in India, the availability of WGS studies is limited.

Cell Line and Augument Cellular Uptake Study of Statistically Optimized Sustained Release Capecitabine Loaded Eudragit S100/PLGA(poly(lacticco- glycolic acid)) Nanoparticles for Colon Targeting.

Background: Capecitabine, an anti cancer drug, has a very short drug elimination half-life (0.49 to 0.89 h).

An unorthodox innervation of the gluteus maximus muscle and other associated variations: A case report.

Knowledge of peripheral nerve morphology, location, and variation is important for facilitating appropriate diagnosis and intervention. We present a unique case of absence of the inferior gluteal nerve and high division of the sciatic nerve. In this instance, the common peroneal nerve was found piercing the piriformis muscle and emerging distally in the form of two trunks: thin medial and thick lateral.

Design and evaluation of herbal hepatoprotective formulation against paracetamol induced liver toxicity.

Aim: To isolate and identify the quercetin from polyherbal hepatoprotective formulation. Polyherbal formulations were developed by using five bioactive fractionated extracts of Butea monosperma, Bauhinia variegata and Ocimum gratissimum for treatment of liver disorders by exploiting the knowledge of traditional system of medicine and evaluated for hepatoprotective activity using acute liver toxicity model of paracetamol induced liver damage in rats.

Methods: Major active fractions were isolated by solvent fractionation and quantified by HPTLC method.