Serum neurofilament-light and glial fibrillary acidic protein levels in hydroxychloroquine-treated primary progressive multiple sclerosis.

Background: In a recent trial, hydroxychloroquine (HCQ) treatment reduced the expected rate of disability worsening at 18 months in primary progressive multiple sclerosis (PPMS). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are emerging biomarkers in multiple sclerosis.

Methods: We measured NfL and GFAP levels in serum samples from 39 patients with inactive PPMS included in a phase II clinical trial of HCQ treatment in PPMS at multiple time points over 18 months, and investigated the association of these biomarkers with clinical disability at screening and during follow-up.

Visual function and patient experience after bilateral implantation of toric intraocular lenses.

Purpose: To evaluate the efficacy, stability, predictability, and patient-reported outcomes of bilateral toric intraocular lens (IOL) implantation in cases of cataract with preexisting astigmatism.

Setting: Fourteen universities, hospitals, or private practices, Canada.

Methods: Patients with cataracts and corneal astigmatism from 1.

Oral pilocarpine for the treatment of keratoconjunctivitis sicca with central corneal irregularity.

A 31-year-old female physician with bilateral myopia had unilateral myopic laser in situ keratomileusis in the right eye. The patient was overcorrected with the initial treatment and had 2 subsequent hyperopic treatments, resulting in central corneal irregularity. During the course of treatment, the patient was diagnosed with Sjögren's syndrome with marked keratoconjunctivitis sicca.

Unfolder lens injection system with acrylic intraocular lenses: retrospective study.

Purpose: To examine the efficacy of using the Unfolder Sapphire series system (Allergan) for implanting acrylic intraocular lenses (IOLs) with a 6.0 mm optic (Sensar AR40, Allergan).

Setting: Ambulatory day-surgery center.