Preconcentration and detection of SARS-CoV-2 in wastewater: A comprehensive review.

Severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) affected the health of human beings and the global economy. The patients with SARS-CoV-2 infection had viral RNA or live infectious viruses in feces. Thus, the possible transmission of SARS-CoV-2 through wastewater received great attentions.

Genotoxicity Assessment of Haloacetaldehyde Disinfection Byproducts via a Simplified Yeast-Based Toxicogenomics Assay.

Haloacetaldehydes (HALs) represent the third-largest category of disinfection byproducts (DBPs) in drinking water in terms of weight. As a subset of unregulated DBPs, only a few HALs have undergone assessment, yielding limited information regarding their genotoxicity mechanisms. Herein, we developed a simplified yeast-based toxicogenomics assay to evaluate the genotoxicity of five specific HALs.

Ultrasensitive Screening of Endocrine-Disrupting Chemicals Using a Surface Plasmon Resonance Biosensor with Polarization-Compensated Laser Heterodyne Feedback.

Developing an ultrasensitive and reliable device for continuous monitoring of various endocrine-disrupting chemicals (EDCs) is in high demand, yet it remains a significant challenge. Traditional label-free surface plasmon resonance (SPR) sensing relies on the interaction of the surface plasmon wave and the sensing liquid via intensity modulation, endowed with simple structure and easy-to-miniaturization, however suffering from inferior sensitivity and stability. Here, we propose a novel optical structure in which the frequency-shifted light of different polarization returned to the laser cavity to stimulate laser heterodyne feedback interferometry (LHFI), hence amplifying the reflectivity change caused by the refractive index (RI) variations on the gold-coated SPR chip surface, and the s-polarized light could be further used as a reference to compensate for the noise of the LHFI-amplified SPR system, resulting in nearly three orders of magnitude enhancement of the RI sensing resolution (5.

Two-dimensional material-enhanced surface plasmon resonance for antibiotic sensing.

Two-dimensional (2D) materials attract attention from the academic community due to their excellent properties, and their wide application in sensing is expected to revolutionize environmental monitoring, medical diagnostics, and food safety. In this work, we systematically evaluate the effects of 2D materials on the Au chip surface plasmon resonance (SPR) sensor. The results reveal that 2D materials cannot improve the sensitivity of intensity-modulated SPR sensors.

An Ultrasensitive and Universal Surface Plasmonic Biosensor for Detection of Micropollutants in Aquatic Environments.

Simple yet ultrasensitive and accurate quantification of a variety of analytical targets by virtue of a universal sensing device holds promise to revolutionize environmental monitoring, medical diagnostics, and food safety. Here, we propose a novel optical surface plasmon resonance (SPR) system in which the frequency-shifted light of different polarizations returned the laser cavity to stimulate laser heterodyne feedback interferometry (LHFI), hence amplifying the reflectivity change caused by the refractive index (RI) variations on the gold-coated SPR chip surface. In addition, the -polarized light was further used as the reference to compensate the noise of the LHFI-amplified SPR system, resulting in nearly 3 orders of magnitude enhancement of RI resolution (5.

Detection of Retinoic Acid-Active Chemicals in Diverse Sample Matrices Via a Quantum Dots-Based Nuclear Receptor Fluorescence Probe-Mediated Biosensor.

Developing a sensitive and reliable method for the screening of various endocrine-disrupting chemicals (EDCs) is in high demand and yet remains a significant challenge. Herein, we developed a CdSe/ZnS QDs-based nuclear receptor fluorescence probe (QDs-NRFP)-mediated biosensor for the screening of retinoic acid (RA)-active chemicals (a class of EDCs). The QDs-NRFP can be prepared on the spot via an antigen-antibody immunobinding interaction between the GST tag of the human retinoic acid receptor β ligand-binding domain (GST-hRARβ-LBD) and the CdSe/ZnS QDs-labeled anti-GST tag antibody.

Group-targeting sulfonamides via an evanescent-wave biosensor based on rational designed coating antigen.

In order to effectively monitor a wide variety of sulfonamides residues in the environment, group-targeting immunoassay based on the group-specific antibodies has attracted great attentions, which can realize the detection of a group of contaminants in environment as many as possible even the unrecognized ones. Indirect competitive immunoassay is generally adopted for small molecule detection however the rational design of immobilized coating antigen for improved recognition capability on the solid surface is far from enough. To cover the research gap, we proposed the design criteria of coating antigen for surface-based indirect competitive immunoassay based on the molecular docking.

Screening of Endocrine Disrupting Potential of Surface Waters via an Affinity-Based Biosensor in a Rural Community in the Yellow River Basin, China.

Overcoming the limitations of traditional analytical methods and developing technologies to continuously monitor environments and produce a comprehensive picture of potential endocrine-disrupting chemicals (EDCs) has been an ongoing challenge. Herein, we developed a portable nuclear receptor (NR)-based biosensor within 90 min to perform highly sensitive analyses of a broad range of EDCs in environmental water samples. Based on the specific binding of the fluorescence-labeled NRs with their ligands, the receptors were attached to the EDC-functionalized fiber surface by competing with EDCs in the samples.

CuS QDs/CoO Polyhedra-Driven Multiple Signal Amplifications Activated h-BN Photoeletrochemical Biosensing Platform.

Herein, we developed an unmodified hexagonal boron nitride (h-BN) photoelectrochemical (PEC) biosensing platform with a low background signal and high sensitivity based on CuS quantum dots (QDs)/CoO polyhedra-driven multiple signal amplifications. The prepared porous h-BN nanosheets with large specific surface areas, as the photoelectric substrate material, can provide extensive active reaction sites. Meanwhile, the CuS QDs/CoO polyhedra were synthesized by the zeolitic imidazolate framework (ZIF-67) and utilized as a multiple signal amplifier, which can not only drive the p-n semiconductor quenching effect to compete with the h-BN photoelectrode for the consumption of electron donors and exciting light but also trigger a mimetic enzymatic catalytic precipitation effect to inhibit electron transfer.

Visible light-activated self-powered photoelectrochemical aptasensor for ultrasensitive chloramphenicol detection based on DFT-proved Z-scheme AgCrO/g-CN/graphene oxide.

A visible light self-powered photoelectrochemical (PEC) aptasensor based on silver chromate particles, graphitic carbon nitride nanosheets and graphene oxide sheets (AgCrO/g-CN/GO) for the ultrasensitive detection of chloramphenicol (CAP) was reported in this work. g-CN was considered to be the fundamental photoelectric material because of its great oxidation ability of photogenerated hole as well as excellent biocompatibility and low toxicity. However, the narrow light absorption range and rapid carrier recombination rate limit the application of pure g-CN.

Au/CeO/g-CN heterostructures: Designing a self-powered aptasensor for ultrasensitive detection of Microcystin-LR by density functional theory.

Quantum-sized cerium dioxide (CeO) show high catalytic capability as well as strong light absorption ability owing to its redox couple Ce/Ce and abundant oxygen vacancies, which making it a potential material for designing superior photoelectrochemical (PEC) sensors. However, it has scarcely been applied in the field of PEC sensing, because its wide band gap and aggregation effect can restrict the photoelectric conversion efficiency. Herein, we address these two obstacles by coupling CeO quantum dots (QDs) with graphitic carbon nitride (g-CN) and Au nanoparticles (NPs).

Ultrathin PtNi nanozyme based self-powered photoelectrochemical aptasensor for ultrasensitive chloramphenicol detection.

Nanozymes have gained increasing attention in the field of biosensing. Rationally designed nanozymes with excellent catalytic activity are accessible to substitute natural enzymes. Herein, a novel self-powered photoelectrochemical (PEC) aptasensor was constructed for ultrasensitive detection of chloramphenicol (CAP) based on ultrathin PtNi nanowires (NWs) as nanozyme and benzene-ring doped g-CN (BR-CN) as the photoactive material.

Highly sensitive detection of microcystin-LR under visible light using a self-powered photoelectrochemical aptasensor based on a CoO/Au/g-CN Z-scheme heterojunction.

Based on the unique photoelectrochemical properties of a CoO/Au/g-CN Z-scheme heterojunction, a self-powered photoelectrochemical (PEC) aptasensor was constructed for the detection of microcystin-leucine arginine (MC-LR). Z-scheme heterojunctions can promote the separation of a photo-induced electron-hole pair, and the surface plasmonic resonance (SPR) of Au nanoparticles can significantly enhance the adsorption of visible light. Importantly, MC-LR molecules were captured by aptamers initially immobilized on the modified electrode due to their high affinity, and then oxidized by the photogenerated holes, which caused an amplified photocurrent signal, allowing the quantitative analysis of MC-LR by measuring the photocurrent intensity change.