We present shipborne observations of volatile organic compounds such as dimethylsulfide (DMS), isoprene, acetaldehyde, acetone, and methanol over the Southern Ocean in April and May 2018. During the cruise, we encountered air masses influenced by the open ocean, coastal Antarctica, and sea ice. No direct correlation between oceanographic parameters and ambient distributions of VOCs is found.
View Article and Find Full Text PDFBackground: Microfracture is the most common procedure for cartilage lesions during medial opening-wedge high tibial osteotomy (MOWHTO), but microdrilling has recently been introduced as an alternative technique.
Purpose: To compare the clinical, radiologic, and arthroscopic outcomes of microfracture and microdrilling during MOWHTO.
Study Design: Cohort study; Level of evidence, 3.
Purpose: To compare the patient-reported outcome (PRO) improvements and cartilage status of trochlear cartilage defects (TCDs) after additional arthroscopic microdrilling versus no treatment for TCDs during medial open-wedge high tibial osteotomy (MOWHTO).
Methods: Patients who underwent MOWHTO with either microdrilling (group M) or no treatment (group N) for near full-thickness TCDs (International Cartilage Repair Society grade IIIB or greater) from March 2010 to September 2022 were retrospectively reviewed, with a minimum 2-year follow-up. 1:1 Propensity score-matched group N was created.
Passive temperature controls like passive daytime radiative cooling (PDRC)-heating (PDRH), and thermal insulation are essential to meet the growing demand for energy-efficient thermal solutions. When combined with advanced functions like electromagnetic interference shielding, these technologies can significantly enhance scalability. However, existing approaches using single thin films or uniform porous materials face inherent limitations in optimizing versatile functions, while lightweight, insulating aerogels can extend their multifunctionality by manipulating pores and fillers.
View Article and Find Full Text PDFDesalination techniques using the photothermal effect hold significant potential for producing fresh water from saline or polluted sources due to their low energy consumption. In the case of commercialized carbon materials are related to heat loss resulting from high thermal conductivity, and metal particles still have trouble in commercialization or cost-effectiveness. This is because a photothermal desalination evaporator must simultaneously exhibit high water evaporation performance, excellent energy conversion efficiency, sufficient hydrophilicity, and low heat loss.
View Article and Find Full Text PDFIn traditional TEMPO oxidation systems, the high cost of TEMPO catalysts has been a significant barrier to the industrialization of oxidized CNF. From an economic perspective, presenting the characteristics of various CNFs produced with the oxidation systems with reduced catalyst usage could facilitate the industrial application of CNF across a wide range of fields. In this study, it was demonstrated that reducing the amount of TEMPO catalyst used (from 0.
View Article and Find Full Text PDFThis study aims to build a comprehensive dataset that enables the automatic evaluation of piano performances. In real-world piano performance, especially within the realm of classical piano music, we encounter a vast spectrum of performance variations. The challenge lies in how to effectively evaluate these performances.
View Article and Find Full Text PDFSulfate radical (SO)-based advanced oxidation processes (SR-AOPs) have been studied to date by utilizing metal-organic frameworks as efficient catalysts to generate sulfate radicals by peroxymonosulfate (PMS) activation in water purification. It is important to select high-performance and reliable catalysts for efficient water remediation, and separation and recovery of catalysts are essential in the practical application of MOFs. Herein, we adapted thermally curable, shape-controllable, and cost-effective agarose (AG) as a smart matrix and ZIF-67, as a powerful catalyst to prepare nanoarchitectured aerogel (Z67@AG).
View Article and Find Full Text PDFThe Chinese artichoke (Stachys affinis syn. S. sieboldii) is a widely cultivated crop, and its rhizome is used as a medicinal vegetable.
View Article and Find Full Text PDFThe endosomal sorting complexes required for transport (ESCRT) machinery is an evolutionarily conserved cytosolic protein complex that plays a crucial role in membrane remodeling and scission events across eukaryotes. Initially discovered for its function in multivesicular body (MVB) formation, the ESCRT complex has since been implicated in a wide range of membrane-associated processes, including endocytosis, exocytosis, cytokinesis, and autophagy. Recent advances have elucidated the ESCRT assembly pathway and highlighted the distinct functions of the various ESCRT complexes and their associated partners.
View Article and Find Full Text PDF: Consensus has not yet been reached regarding combined anterior cruciate ligament reconstruction (ALLR) with revisional anterior cruciate ligament reconstruction (RACLR). We aimed to compare the clinical outcomes between patients who underwent isolated RACLR and those who underwent RACLR combined with ALLR. : Between June 2010 and June 2021, 49 patients who underwent RACLR were retrospectively reviewed over a 24-month follow-up.
View Article and Find Full Text PDFThe epidermal growth factor receptor (EGFR) is an important target for cancer therapies. Many head and neck cancer (HNC) cells have been reported to overexpress EGFR; therefore, anti-EGFR therapies have been attempted in patients with HNC. However, its clinical efficacy is limited owing to the development of drug resistance.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast cancer types, indicating a poor survival prognosis with a more aggressive biology of metastasis to the lung and a short response duration to available therapies. Ibulocydine (IB) is a novel (cyclin-dependent kinase) CDK7/9 inhibitor prodrug displaying potent anti-cancer effects against various cancer cell types. We performed in vitro and in vivo experiments to determine whether IB inhibits metastasis and eventually overcomes the poor drug response in TNBC.
View Article and Find Full Text PDFBackground: In vitro disease modeling enables translational research by providing insight into disease pathophysiology and molecular mechanisms, leading to the development of novel therapeutics. Nevertheless, in vitro systems have limitations for recapitulating the complexity of tissues, and a single model system is insufficient to gain a comprehensive understanding of a disease.
Results: Here we explored the potential of using several models in combination to provide mechanistic insight into hereditary hemorrhagic telangiectasia (HHT), a genetic vascular disorder.
Muscle atrophy is a debilitating condition with various causes; while aging is one of these causes, reduced engagement in routine muscle‑strengthening activities also markedly contributes to muscle loss. Although extensive research has been conducted on microRNAs (miRNAs/miRs) and their associations with muscle atrophy, the roles played by miRNA precursors remain underexplored. The present study detected the upregulation of the miR‑206 precursor in cell‑free (cf)RNA from the plasma of patients at risk of sarcopenia, and in cfRNAs from the muscles of mice subjected to muscle atrophy.
View Article and Find Full Text PDFThe chemical/physical properties and reliable performance of nanoporous materials are strongly influenced by the particle size and corresponding distribution. Among many types of MOFs, ZIF-8, is still widely used and many studies have been conducted to control the particle size and uniformity of ZIF-8 using surfactants and organic solvents. However, the use of surfactants and organic solvents process is expensive and may cause environmental pollution.
View Article and Find Full Text PDFBackground: Unintended secondary changes in the posterior tibial slope (PTS) and tibial torsion angle (TTA) may occur after medial open-wedge high tibial osteotomy (MOWHTO). In surgical procedures using patient-specific instruments (PSIs), it is essential to reproduce the PTS and TTA that were planned in simulations.
Purpose: To analyze the factors causing unintended sagittal and axial alignment changes after MOWHTO.
Metal-organic framework (MOF) particles are one of the most promising adsorbents for removing organic contaminants from wastewater. However, powder-type MOF particles face challenges in terms of utilization and recovery. In this study, a novel bead-type adsorbent was prepared using activated carbon based on the zeolitic imidazolate framework-8 (AC-ZIF-8) and a regenerated cellulose hydrogel for dye removal.
View Article and Find Full Text PDFbelongs to the family and is used as both an oilseed and vegetable crop. As only a few studies have reported on the cucumber mosaic virus (CMV) in , we conducted this study to provide a basic understanding of the and CMV interactions. -infecting CMV (CMV-Co6) and non-infecting CMV (CMV-Rs1) were used.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
April 2024
Purpose: To compare the outcomes of treating large cartilage defects in knee osteoarthritis using human allogeneic umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation or arthroscopic microdrilling as a supplementary cartilage regenerative procedure combined with high tibial osteotomy (HTO).
Methods: This 1-year prospective comparative study included 25 patients with large, near full-thickness cartilage defects (International Cartilage Repair Society grade ≥ IIIB) in the medial femoral condyles and varus malalignment. Defects were treated with hUCB-MSC implantation or arthroscopic microdrilling combined with HTO.
Objective: To analyze the prognostic factors for clinical outcomes and cartilage regeneration after the implantation of allogeneic human umbilical cord blood mesenchymal stem cell (hUCB-MSC) for treating large-sized cartilage defects with osteoarthritis.
Design: This study is a case-series with multiple subgroup analyses that divides the included patients into multiple subgroups based on various factors. Overall, 47 patients who underwent hUCB-MSC implantation were included.
This study compared cartilage regeneration outcomes in knee osteoarthritis (OA) using allogeneic human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation and microdrilling with high tibial osteotomy (HTO). Fifty-four patients (60 knees) were included: 24 (27 knees) in the hUCB-MSC group and 30 (33 knees) in the microdrilling group. Both groups showed significant improvements in pain and functional scores at 6, 12, and 24 months compared to baseline.
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