Proteins are constructed from amino acid sequences. Their structural classifications include primary, secondary, tertiary, and quaternary, with tertiary and quaternary structures influencing protein function. Because a protein's structure is inextricably connected to its biological function, machine learning algorithms that can better anticipate the structures have the potential to lead to new scientific discoveries in human health and improve our capacity to develop new treatments.
View Article and Find Full Text PDFKnowledge about protein structure assignment enriches the structural and functional understanding of proteins. Accurate and reliable structure assignment data is crucial for secondary structure prediction systems. Since the 1980s, various methods based on hydrogen bond analysis and atomic coordinate geometry, followed by machine learning, have been employed in protein structure assignment.
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