Publications by authors named "Jiro Ohara"

Background: A bipartite atlas is a rare congenital anomaly characterized by incomplete fusion of the anterior and posterior arches of the first cervical vertebra (C1). While typically asymptomatic, this condition can result in cervical myelopathy when accompanied by degenerative changes. This report presents a rare case of cervical myelopathy caused by a bipartite atlas in an older patient that required surgical intervention.

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Background: Ganglioneuroma is a benign and well-differentiated tumor derived from neural crest cells, which occurs infrequently, with most patients being female and adolescents. While predilection sites are the posterior mediastinum and retroperitoneal cavity, ganglioneuroma originating from the dorsal root ganglion is very rare. Here the authors report a case with C2 dorsal root ganglion-derived ganglioneuroma with some literature review.

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We present a 69-year-old woman with colorectal cancer and a left frontal lobe tumor that was diagnosed as a cerebral amyloidoma after surgical resection. Further postoperative systemic evaluation revealed another amyloidoma in her hip as well as Sjögren's syndrome. Systemic amyloidosis was not present.

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We describe three cases with acute middle cerebral artery (MCA) occlusion. From the pre-operative MRI, including three-dimensional turbo spin-echo sequences using T1WI and T2WI, we assessed both thrombus configuration and arterial anatomy at the MCA bifurcations. For efficient endovascular thrombectomy, we identified the applied MCA segment 2 (M2) branch, in which the main thrombus was buried.

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The goal of surgery for degenerative spine disease is to decompress nerves; however, extensive spinal decompression may compromise spinal stability. Therefore, spinal fusion surgery is performed to immediately stabilize such anatomical disruption during a short hospital stay and to allow quick recuperation. Recently, implants such as pedicle screws and intervertebral cages have been regularly used in lumbar fusion surgery.

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Segmental arterial mediolysis(SAM)is a rare non-inflammatory and non-atherosclerotic arteriopathy associated with the occurrence of multiple aneurysms such as intracranial and intraperitoneal aneurysms. We report a case of intraperitoneal hemorrhage that occurred during the acute stage of subarachnoid hemorrhage(SAH). An 82-year-old woman presented with a sudden onset of loss of consciousness with a diagnosis of SAH.

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Article Synopsis
  • The proteasome is an enzyme complex that breaks down both normal and damaged proteins, but its activity declines with age, potentially leading to age-related diseases.
  • Researchers created a transgenic mouse model with reduced proteasomal activity, which resulted in shorter lifespans and the development of age-related traits like obesity and liver fat accumulation when fed a high-fat diet.
  • The study suggests that decreased proteasomal activity has a significant impact on longevity and heightens age-related metabolic disorders, offering new insights into how these processes might relate to aging.
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Strongyloidiasis, a chronic infection caused by the intestinal parasite Strongyloides stercoralis, is prevalent in the Nansei Islands of Japan. Here, we report our findings on a case of strongyloidiasis complicated with steroid-resistant minimal change nephrotic syndrome in a 69-year-old male resident of Fukuoka Prefecture who had lived in Yakushima, one of the Nansei Islands, until age 15. In October 2006, he developed proteinuria and edema, and was diagnosed with minimal change nephrotic syndrome on the basis of the renal biopsy findings.

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Article Synopsis
  • - The ubiquitin-proteasome pathway is crucial for degrading proteins and producing peptides important for immune response, and it involves the 20S proteasome, which has three main beta subunits.
  • - A new beta subunit, beta5t, found only in cortical thymic epithelial cells in mice, is part of the thymoproteasome that plays a role in positive selection of T-cells.
  • - This study reveals that human beta5t is also found exclusively in the thymic cortex, suggesting that the functional role of thymoproteasomes is similar in both humans and mice, as it forms specialized proteasomes with distinct compositions.
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The selection of sheep with scrapie-resistant PrP genotypes is one of the control measures for transmissible spongiform encephalopathies in ruminants. In this study, we investigated the frequencies of PrP genotypes in meat breeds in Japan. The nationwide surveillance revealed that nearly half of the Suffolk sheep, a major meat breed in Japan, carried scrapie-susceptible AQ/AQ and AQ/VQ genotypes.

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