Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment.

Purpose: Photoreceptor degeneration is a major cause of visual loss in various retinal diseases, including retinal detachment (RD) and neovascular AMD, but the underlying mechanisms remain elusive. In this study, the role of TNFα in RD-induced photoreceptor degeneration was investigated.

Methods: RD was induced by subretinal injection of hyaluronic acid.