Publications by authors named "Jirimutu Xiao"

This study utilized bioinformatics and data mining techniques to explore the molecular mechanism of curcumin in treating osteoporosis (OP) through the lens of ferroptosis, thereby identifying novel therapeutic targets. The datasets GSE35958, GSE35956, GSE7429, and GSE7158 were obtained from the Gene Expression Omnibus (GEO) database. GSE35958 and GSE35956 were employed as training sets for data integration, while GSE7429 and GSE7158 served as independent validation sets.

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Article Synopsis
  • Previous studies showed that p-Smad3 helps in the growth and development of osteoblasts and influences intercellular communication factors, but its effects on osteoclast behaviors weren't well understood.
  • The research involved treating immature and mature osteoblasts with specific activators and inhibitors to see how p-Smad3 affected osteoclast lineage cells through the medium they produced.
  • Results indicated that p-Smad3 initially facilitates osteoclast migration and differentiation from immature osteoblasts but later promotes osteoclast apoptosis and angiogenesis as osteoblasts mature.
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Background: Narenmandula is a classic ancient remedy in Inner Mongolia, historically used for gastrointestinal diseases. In recent decades, Inner Mongolia Medical University found that it has a significant effect in promoting fracture healing and increasing bone density, and has been used to treat postmenopausal osteoporosis (PMOP), but its mechanism is unclear.

Objective: Identify the mechanism of action of Narenmandula for PMOP treatment.

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Osteoporosis is a chronic inflammatory disease that severely affects quality of life. is a Chinese herbal medicine with various bioactive ingredients, among which morroniside is its signature ingredient. Although anti-bone resorption drugs are the main treatment for bone loss, promoting bone anabolism is more suitable for increasing bone mass.

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Quercetin, a flavonoid found in natural medicines, has shown a role in disease prevention and health promotion. Moreover, because of its recently identified contribution in regulating bone homeostasis, quercetin may be considered a promising agent for improving bone health.This study aimed to elucidate the role of quercetin in androgen deprivation therapy-induced osteoporosis in mice.

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Osteoblasts primarily mediate bone formation, maintain bone structure, and regulate bone mineralization, which plays an important role in bone remodeling. In the past decades, the roles of cytokines, signaling proteins, and transcription factors in osteoblasts have been widely studied. However, whether the energy metabolism of cells can be regulated by these factors to affect the differentiation and functioning of osteoblasts has not been explored in depth.

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Introduction: The occurrence of osteoporosis (OP) has drawn considerable attention from scholars around the world due to the significant impacts thereof on the social economy and the quality of human life. OP research has been rapidly expanding since the inclusion of microRNAs (miRNAs) as critical regulators of gene-expression. However, despite the ability to evaluate miRNA gene therapy in OP being enhanced, there has been a scarcity of updated citation analyses that reflect such developments.

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