Publications by authors named "Jireh Yi-Le Chan"
Article Synopsis
- The study investigates the issue of multicollinearity among genes in high-throughput RNA-Seq data, which can affect the reliability of predictive models.
- Six genes associated with embryotoxicity were identified and validated using qPCR after being exposed to various substances, with Zfp42 and Hoxb1 highlighted as potential early biomarkers.
- The researchers implemented a systematic methodology combining machine learning and statistical analyses, successfully reducing redundancies and improving predictive accuracy, ultimately benefiting embryotoxicity screening research.
Article Synopsis
- * The study introduces a mouse embryoid body test (EBT) model using a 384-well format, aimed at improving screening for early developmental toxicity of chemicals.
- * The EBT model showed an 84.38% accuracy in predicting developmental toxicity for various compounds, offering a promising solution for efficient chemical safety assessments.
Background: Different processing conditions alter the ginseng bioactive compounds, promoting or reducing its anti-inflammatory effects. We compared black ginseng (BG) - that have been steamed 5 times - with red ginseng (RG).
Hypothesis/ Purpose: To compare the anti-inflammatory activities and the anti-nociceptive properties of RG and BG.