Publications by authors named "Jiquan Zhou"
Article Synopsis
- Neonatal hepatoblastoma (HB), diagnosed within the first month of life, presents unique challenges in treatment and prognosis, prompting a study to analyze its diagnosis, treatment, and outcomes at a single center.
- The study observed 79 patients under one year old, identifying 14 with neonatal HB, which exhibited distinct clinical features such as smaller tumor size and higher tumor grades compared to non-neonatal cases, along with significantly elevated AFP levels.
- Results indicated a 100% three-year survival rate and event-free survival for neonatal HB patients, demonstrating that combined treatment strategies of surgery and chemotherapy can be highly effective, warranting further research in larger populations.
ACLY-β-catenin axis modulates hepatoblastoma cell proliferation.
Biochem Biophys Res Commun
June 2023
HB (hepatoblastoma) is most common in children with liver cancer and few options for treating HB. Thus, it is of great significance to investigate the regulatory mechanism of HB and/or identify new therapeutic targets for clinical treatment of HB. Here, we showed that ACLY (ATP citrate lyase), an important lipometabolic enzyme for de novo biosynthesis of fatty acids and steroids, has a higher expression in HB tissues than noncancerous tissues, and is required for HB cell proliferation.
View Article and Find Full Text PDFFerroptosis Inducers Kill Mesenchymal Stem Cells Affected by Neuroblastoma.
Cancers (Basel)
February 2023
Bone marrow (BM) is the most common site of neuroblastoma (NB) metastasis, and its involvement represents poor patient prognosis. In accordance with the "seed and soil" theory of tumor metastasis, BM provides a favorable environment for NB metastasis while bone marrow mesenchymal stem cells (BMSCs) have been recognized as a central part of tumor stroma formation. Yet, there is currently no effective method for intervening these BMSCs.
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