promotes osteoblast differentiation and alleviates osteoporosis via the // axis.

This study was designed to elucidate the role of and functions in postmenopausal osteoporosis. Mice were ovariectomized to establish an osteoporosis model and MC3T3-E1-14 osteoblasts were induced to differentiate. Gain- or loss-of-function approaches were used to manipulate the expression of ,  and , followed by an evaluation of their role in postmenopausal osteoporosis both and .