5-Hydroxyindoleacetic acid (5-HIAA), a vital metabolite of serotonin (5-HT), is crucial for understanding metabolic pathways and is implicated in various mental disorders. In situ monitoring of 5-HIAA is challenging due to the lack of affinity ligands and issues with electrochemical fouling. We present an advanced sensing approach that integrates customizable molecular imprinting polymer (MIP) with self-driven galvanic redox potentiometry (GRP) for precise, real-time in vivo monitoring of 5-HIAA.
View Article and Find Full Text PDFMonitoring extracellular calcium ion (Ca) chemical signals in neurons is crucial for tracking physiological and pathological changes associated with brain diseases in live animals. Potentiometry based solid-state ion-selective electrodes (ISEs) with the assist of functional carbon nanomaterials as ideal solid-contact layer could realize the potential response for in vitro and in vivo analysis. Herein, we employ a kind of biomass derived porous carbon as a transducing layer to prompt efficient ion to electron transduction while stabilizes the potential drift.
View Article and Find Full Text PDFSelective and nondisruptive in vivo neurochemical monitoring within the central nervous system has long been a challenging endeavor. We introduce a new sensing approach that integrates neurocompatible galvanic redox potentiometry (GRP) with customizable phosphorothioate aptamers to specifically probe dopamine (DA) dynamics in live rat brains. The aptamer-functionalized GRP (aptGRP) sensor demonstrates nanomolar sensitivity and over a 10-fold selectivity for DA, even amidst physiological levels of major interfering species.
View Article and Find Full Text PDFUnlike the previous commonly used strong alkaline solvent sodium hydroxide, we employ an eco-friendly solvent, ethanol, as a solvent for the preparation of ultra-small-sized sulfur quantum dots (SQDs). Ethanol can disperse bulk sulfur and allow sufficient transfer of large-sized sulfur to smaller-sized SQDs through a one-pot synthesis approach. The SQDs obtained from ethanol as the solvent displays superior photoluminescence properties to those in water and sodium hydroxide.
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