PURPL Promotes M2 Macrophage Polarization in Lung Cancer by Regulating RBM4/xCT Signaling.

Lung cancer is the most common malignancy worldwide. Long non-coding RNA (lncRNA) p53 upregulated regulator of P53 levels (PURPL) is abnormally in various cancers. However, the reports on its roles in lung cancer are limited.

KIAA1429-mediated RXFP1 attenuates non-small cell lung cancer tumorigenesis via N6-methyladenosine modification.

Background: N6-methyladenosine (m6A) modification has been associated with non-small cell lung cancer (NSCLC) tumorigenesis.

Objectives: This study aimed to determine the functions of Vir-like m6A methyltransferase-associated (KIAA1429) and relaxin family peptide receptor 1 (RXFP1) in NSCLC.

Methods: A quantitative real-time polymerase chain reaction was used to analyze the mRNA levels of KIAA1429 and RXFP1 in NSCLC.

A nomogram for predicting cause-specific mortality among patients with cecal carcinoma: a study based on SEER database.

Objective: Classical Cox proportional hazard models tend to overestimate the event probability in a competing risk setup. Due to the lack of quantitative evaluation of competitive risk data for colon cancer (CC), the present study aims to evaluate the probability of CC-specific death and construct a nomogram to quantify survival differences among CC patients.

Methods: Data on patients diagnosed with CC between 2010 and 2015 were collected from the Surveillance, Epidemiology, and End Results Program (SEER) database.

Multi-Attribute Subspace Clustering via Auto-Weighted Tensor Nuclear Norm Minimization.

Self-expressiveness based subspace clustering methods have received wide attention for unsupervised learning tasks. However, most existing subspace clustering methods consider data features as a whole and then focus only on one single self-representation. These approaches ignore the intrinsic multi-attribute information embedded in the original data feature and result in one-attribute self-representation.

Adaptive graph convolutional clustering network with optimal probabilistic graph.

The graph convolutional network (GCN)-based clustering approaches have achieved the impressive performance due to strong ability of exploiting the topological structure. The adjacency graph seriously affects the clustering performance, especially for non-graph data. Existing approaches usually conduct two independent steps, i.

Logarithmic Schatten- p Norm Minimization for Tensorial Multi-View Subspace Clustering.

The low-rank tensor could characterize inner structure and explore high-order correlation among multi-view representations, which has been widely used in multi-view clustering. Existing approaches adopt the tensor nuclear norm (TNN) as a convex approximation of non-convex tensor rank function. However, TNN treats the different singular values equally and over-penalizes the main rank components, leading to sub-optimal tensor representation.

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide.

At present, the potential of natural products in new drug development has attracted more and more scientists' attention, and natural products have become an important source for the treatment of various diseases or important lead compounds. Geniposide, as a novel iridoid glycoside compound, is an active natural product isolated from the herb Ellis (GJ) for the first time; it is also the main active component of GJ. Recent studies have found that geniposide has multiple pharmacological effects and biological activities, including hepatoprotective activity, an anti-osteoporosis effect, an antitumor effect, an anti-diabetic effect, ananti-myocardial dysfunction effect, a neuroprotective effect, and other protective effects.

Gut microbiota and differential genes-maintained homeostasis is key to maintaining health of individuals with Yang-deficiency constitution.

Objective: Yang-deficiency constitution (YADC) is a common unbalanced constitution that predisposes individuals to certain diseases. However, not all people with YADC manifest develop diseases. This calls for delineation of the underlying molecular mechanisms.

Barrier Properties and Hydrophobicity of Biodegradable Poly(lactic acid) Composites Reinforced with Recycled Chinese Spirits Distiller's Grains.

Adding natural biomass to poly(lactic acid) (PLA) as a reinforcing filler is a way to change the properties of PLA. This paper is about preparing PLA/biomass composites by physically melting and blending Chinese Spirits distiller's grains (CSDG) biomass and PLA to optimize the composite performance. Composites of modified PLA (MPLA) with varying amounts of CSDG were also prepared by the melt-mixing method, and unmodified PLA/CSDG composites were used as a control group for comparative analysis.

Rank Consistency Induced Multiview Subspace Clustering via Low-Rank Matrix Factorization.

Multiview subspace clustering has been demonstrated to achieve excellent performance in practice by exploiting multiview complementary information. One of the strategies used in most existing methods is to learn a shared self-expressiveness coefficient matrix for all the view data. Different from such a strategy, this article proposes a rank consistency induced multiview subspace clustering model to pursue a consistent low-rank structure among view-specific self-expressiveness coefficient matrices.

Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy.

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development.

Synthesis, characterization and catalytic epoxidation properties of lanthanide-stabilized peroxoisopolytungstates.

A series of new lanthanide-containing peroxoisopolyoxotungstates, KNa[H{Ln(WO)(HO)[WO(O)]}]·105HO [Ln = Ce (1), Nd (2), Sm (3), Tb (4), Er (5)], have been successfully synthesized and structurally characterized. All polyanions [Ln(WO)(HO){WO(O)}] are isostructural and consist of a central [Ln(WO)(HO)] cluster surrounded by four peripheral [WO(O)] units. They could act as efficient recyclable catalysts for the epoxidation of various alkenes including different cycloalkenes, styrene derivatives, internal and long-chain alkenes.

A Nanosized Gly-Decorated Praseodymium-Stabilized Selenotungstate Cluster: Synthesis, Structure, and Oxidation Catalysis.

A flexible one-pot strategy with pyramidal Se heteroatoms was employed for the assembly of the praseodymium-containing gly-decorated polyoxotungstate [{Pr (H O) [Se W O (gly) ]} (Se W O H )] (1 a), which is constructed from one {Se W O H } unit and two identical {Pr (H O) [Se W O (gly) ]} units. Furthermore, the catalytic performance of Cs Na H [{Pr (H O) [Se W O (gly) ]} (Se W O H )]⋅25 H O (1) for alkene epoxidation with hydrogen peroxide was investigated under mild reaction conditions, and the experimental results suggested that compound 1 exhibits good catalytic performance for the epoxidation of cyclooctene.

Urinary metabolomic profiling in rats exposed to dietary di(2-ethylhexyl) phthalate (DEHP) using ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS).

Di(2-ethylhexyl) phthalate (DEHP) is an omnipresent environmental chemical with widespread nonoccupational human exposure through multiple ways. Although considerable efforts have been invested to investigate mechanisms of DEHP toxicity, the key metabolic biomarkers of DEHP toxicity remain to be identified. The aim of this study was to assess the urinary metabonomics of dietary DEHP in rats using the technique of ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS).

Ferroptosis: A Novel Anti-tumor Action for Cisplatin.

Purpose: Ferroptosis is a new mode of regulated cell death, which is completely distinct from other cell death modes based on morphological, biochemical, and genetic criteria. This study evaluated the therapeutic role of ferroptosis in classic chemotherapy drugs, including the underlying mechanism.

Materials And Methods: Cell viabilitywas detected by using the methylthiazoltetrazlium dye uptake method.

Effects of Long-Term In Vivo Exposure to Di-2-Ethylhexylphthalate on Thyroid Hormones and the TSH/TSHR Signaling Pathways in Wistar Rats.

Di-(2-ethylhexyl)phthalate (DEHP) was a widely used chemical with human toxicity. Recent in vivo and in vitro studies suggested that DEHP-exposure may be associated with altered serum thyroid hormones (THs) levels, but the underlying molecular mechanisms were largely unknown. To explore the possible molecular mechanisms, 128 Wistar rats were dosed with DEHP by gavage at 0, 150, 300, and 600 mg/kg/day for 3 months (M) and 6 M, respectively.

Interaction Effects between Organochlorine Pesticides and Isoflavones In Vitro and In Vivo.

Organochlorine pesticides (OCPs) have caused increasing global concern due to their high toxicity, persistence, bioaccumulation, and significant adverse effects on human health. This study was to explore the interaction effects between OCPs and isoflavones. Six kinds of OCPs and 2 kinds of isoflavones-genistein and daidzein were included to study their effect on MCF-7 cells in vitro.

A multi-component polyoxometalate and its catalytic performance for CO2 cycloaddition reactions.

A multi-component polyoxometalate based on earth-abundant elements (NH4)10[Co8(H2O)10V10Mo23O104(OH)6]·34.5H2O () has been successfully obtained and characterized. Furthermore, compound acted as a Lewis acid catalyst and promoted the conversion of carbon dioxide to a cyclic carbonate under mild reaction conditions.

Thermolides, potent nematocidal PKS-NRPS hybrid metabolites from thermophilic fungus Talaromyces thermophilus.

Macrocyclic PKS-NRPS hybrid metabolites represent a unique family of natural products mainly from bacteria with broad and outstanding biological activities. However, their distribution in fungi has rarely been reported, and little has been reported regarding their nematocidal activity. Here we describe an unprecedented class of PKS-NRPS hybrid metabolites possessing a 13-membered lactam-bearing macrolactone, thermolides A-F (1-6) from a thermophilic fungus Talaromyces thermophilus.

[The investigation of the strategy of surgical treatment of cholesterol granuloma in the middle ear].

Objective: To investigate the surgical treatment of cholesterol granuloma in middle ear.

Method: Nineteen patients of cholesterol granuloma in middle ear were retrospectively study. All the patients were treated with tympanic tube insertion, canal wall up mastoidectomy or intact-tympanic canal wall down mastoidectomy respectively.

Isolation of talathermophilins from the thermophilic fungus Talaromyces thermophilus YM3-4.

Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus Talaromyces thermophilus strain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1 and 2 are new analogues of the key versatile precursor notoamide E.

Isolation of putative biosynthetic intermediates of prenylated indole alkaloids from a thermophilic fungus Talaromyces thermophilus.

The putative key biosynthetic intermediates of prenylated indole alkaloids have long been proposed but never isolated. Two such alkaloids, named talathermophilins A and B (1 and 2), were isolated from a thermophilic fungus Talaromyces thermophilus strain YM1-3 and were identified by NMR and MS spectroscopic analyses. The ratio of 1 and 2 in the culture broths was unexpectedly rather constant (about 2:3), which even remained unchanged despite the addition of exogenous 1 or 2, suggesting that talathermophilins might be of special function for the extremophilic fungus.