Treat-And-Extend Versus Pro Re Nata Regimen of Intravitreal Conbercept Injection for Neovascular Age-Related Macular Degeneration: Results from COCOA, a Prospective, Open-Label, Multicenter, Randomized Phase IV Clinical Trial.

Purpose: To evaluate and contrast the effectiveness and safety of two conbercept treatment protocols-a three-dose treat-and-extend (3+T&E) regimen and a three-dose pro re nata (3+PRN) regimen-in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).

Methods: Eligible patients, who had not undergone anti-VEGF intraocular injections within 3 months prior to enrollment, were randomly assigned to either the 3+T&E or 3+PRN regimen. The 3+T&E group received at least three monthly injections, with subsequent visit intervals extended based on disease activity assessment.

Crystalline CoP@ Amorphous WP Coaxial Nanowire Arrays as Bifunctional Electrocatalyst for Water Splitting.

The crystalline CoP@ amorphous WP core-shell nanowire arrays are oriented grown on the Ni foam (CoP@WP/NF). The amorphous WP shell provides more active sites, and the interface charge coupling accelerates the kinetic of the catalytic reaction, making the CoP@WP/NF catalysts excellent activity. In acidic, only 13 and 97 mV overpotentials are needed to reach 10 mA cm and 100 mA cm, respectively, which are the lowest overpotentials among all reported Transition metal phosphide (TMP) catalysts, of course, much lower than that of the Pt/C catalyst (31 mV at 10 mA cm, 120 mV at 100 mA cm).

The multi-kingdom microbiome catalog of the chicken gastrointestinal tract.

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and eggs. Despite recent significant advances in gut microbiome studies, a comprehensive study of chicken gut bacterial, archaeal, and viral genomes remains unavailable. In this study, we constructed a chicken multi-kingdom microbiome catalog (CMKMC), including 18,201 bacterial, 225 archaeal, and 33,411 viral genomes, and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes (MAGs) from ten countries.

Healthcare workers' knowledge, attitudes, and practices on catheter-associated UTI prevention: influencing factors in an OB/GYN hospital.

Background: Catheter-associated urinary tract infection (CAUTI) is a leading cause of hospital-acquired infections globally, with a high prevalence in China, especially in high-risk settings like intensive care and post-operative environments. These infections are influenced by factors such as patient volume, healthcare worker training, and adherence to infection control protocols. Shanghai, as a major healthcare hub, faces unique challenges in CAUTI prevention.

Functional redundancy of transcription factors SlNOR and SlNOR-like1 is required for pollen development in tomato.

In tomato, SlNOR and SlNOR-like1 members of the NAC family of transcription factors (TFs), are known to play critical roles in regulating fruit ripening and are highly expressed in floral organs. However, their role in flower development remains unclear. In this study, we generated and functionally characterized a double knockout mutant, .

Effects of propolis intake on endurance exercise and molecular signaling related to inflammation and oxidative stress.

Honey bees extract sticky material from the exudates of different plants which transform afterwards to propolis. Propolis from several global locations has been shown to contain a wide variety of polyphenolic chemicals. Recent studies have revealed that propolis possesses antioxidant, anti-inflammatory, and immunomodulatory abilities.

 (Violaceae), a new species from central Guangxi, China.

(Violaceae), a new species from Guangxi, China, is established on the basis of morphological and molecular evidence. This new species resembles , but differs from the latter by its stipules margin long fimbriate-dentate (vs. fimbriate-dentate), stolon absent (vs.

State-of-the-Art Review of the Performance of Fiber-Reinforced-Composite-Confined Concrete Columns at Ambient Temperatures.

This paper investigates the effect of fiber-reinforced composites (FRPs) on the mechanical properties of concrete under ambient conditions. It begins with an examination of the various types of FRP and their advantages, followed by a review of isostructural models for passively restrained concrete under ambient conditions. These models are categorized into two main groups: those assuming constant confining stresses and those that incorporate stress constraints related to the loading history.

Microstructure Evolution and Mechanical Properties of Grinding Metamorphic for 8Cr4Mo4V Steel.

The formation of surface austenite leads to microstructural changes, causing grinding hardening. However, the effect of grinding mechanical stresses on surface austenitization remains unclear. Additionally, the mechanical properties of the metamorphic layer are crucial for studying grinding hardening.

Characterization of Reclaimed Asphalt Pavement Material Properties for Hot In-Place Recycling.

Asphalt with different aging degrees requires different rejuvenation methods. However, current applications of hot in-place recycling (HIR) for Reclaimed Asphalt Pavement (RAP) do not consider the differences in the aging degree of asphalt binder across different layers of RAP. Additionally, there is limited understanding of the changes in asphalt binder and aggregate properties during the HIR process.

InfoScan: A New Transcript Identification Tool Based on scRNA-Seq and Its Application in Glioblastoma.

InfoScan is a novel bioinformatics tool designed for the comprehensive analysis of full-length single-cell RNA sequencing (scRNA-seq) data. It enables the identification of unannotated transcripts and rare cell populations, providing a powerful platform for transcriptome characterization. In this study, InfoScan was applied to glioblastoma multiforme (GBM), identifying a rare "neoplastic-stemness" subpopulation exhibiting cancer stem cell-like features.

Deep Eutectic Solvents and Wall-Breaking Technique: A New Frontier in the Extraction of Oleuropein and Flavonoids from Olive Leaves with Superior Antioxidant and Antitumor Potential.

The main objectives of this study were to develop an optimized green extraction process to obtain high contents of oleuropein and flavonoids from olive leaves. A deep eutectic solvent (DES) combined with wall-breaking extraction (WBE) was employed. A DES composed of choline chloride and ethylene glycol in a 1:2 molar ratio with 30% moisture content outperformed lactic acid and methanol as extraction solvents.

Deep-Neural-Networks-Based Data-Driven Methods for Characterizing the Mechanical Behavior of Hydroxyl-Terminated Polyether Propellants.

Hydroxyl-terminated polyether (HTPE) propellants are attractive in the weapons materials and equipment industry for their insensitive properties. Storage, combustion, and explosion of solid propellants are affected by their mechanical properties, so accurate mechanical modeling is vital. In this study, deep neural networks are applied to model composite solid-propellant mechanical behavior for the first time.

On-orbit microbial succession patterns of the China Space Station during the construction period.

Background: The China Space Station (CSS) modules feature many areas that are difficult to clean and thus susceptible to microbial outbreaks. A new sampling method utilizing an equivalent material sheet was applied to characterize the diversity of microbes that accumulated in inaccessible areas in orbit on the CSS. Equivalent material sheet is a membrane made of the same material as the wall of the module.

Establishment and application of a wild neonatal mouse model infected with an Echovirus 30 isolate.

Background: Echovirus 30 (E30) is a significant pathogen associated with various illnesses such as viral meningitis, viral myocarditis. Currently, there are no specific drugs or vaccines targeting this virus. An appropriate animal model is imperative for assessing drug and vaccine efficacy.

Integrated analysis and experimental validation reveal the prognostic and immunological features associated with coagulation in hepatocellular carcinoma.

Coagulation is intensively related to various tumors, which affects their progression and prognosis. However, research on the impact of coagulation-associated genes (CAGs) on hepatocellular carcinoma (HCC) occurrence, prognosis, and immune microenvironment is limited. Consequently, our research aims to uncover how CAGs affect the prognosis and immune microenvironments of HCC.

Factors influencing the use of weight management APP among obese patients in Chinese cities in the post-epidemic era.

Objectives: In the post-epidemic era, the prevalence of obesity among urban residents in China has risen sharply, with 34.8% of the population being overweight and 14.1% classified as obese.

Effect of Early Tumor Shrinkage and Depth of Response on the Clinical Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Transcatheter Arterial Chemoembolization and Lenvatinib Plus PD-1 Inhibitors.

Introduction: Systematic therapies, including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs), have now been approved as the mainstay treatment for patients with unresectable hepatocellular carcinoma (uHCC). However, only a minority of the patients are expected to respond to TKIs and ICIs. Because early tumor shrinkage (ETS) and depth of response (DoR) might have the potential to predict survival outcomes, this study aimed to identify the optimal cutoffs for ETS and DoR to predict patients' clinical outcomes in their early treatment stage.

Integrated analysis of transcriptome and metabolome reveals the molecular basis of quality differences in Alpinia oxyphylla Miq. From geo-authentic and non-authentic areas.

Alpinia oxyphylla Miq., a well-accepted medicinal and edible plant in south China. The primary ingredients of this medicine vary significantly depending on their origin, which profoundly impacts its quality.

Predictive value of machine learning for in-hospital mortality risk in acute myocardial infarction: A systematic review and meta-analysis.

Background: Machine learning (ML) models have been constructed to predict the risk of in-hospital mortality in patients with myocardial infarction (MI). Due to diverse ML models and modeling variables, along with the significant imbalance in data, the predictive accuracy of these models remains controversial.

Objective: This study aimed to review the accuracy of ML in predicting in-hospital mortality risk in MI patients and to provide evidence-based advices for the development or updating of clinical tools.

Green and chemical-free pretreatment of flavonoids in tea plant seed husk using ultrasound-cold isostatic pressure synergistic extraction.

A new method was established to extract flavonoids from tea plant seed husk: ultrasonic-cold isostatic pressure synergistic extraction. The effects of pressure, ethanol concentration, tea plant seed husk addition and treatment time on the extraction of flavonoids were investigated. The optimal extraction process was determined as follows: applied pressure 468.

Structure-based molecular hybridization design and synthesis of Keap1-Nrf2 inhibitors for anti-inflammatory treatment.

The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway stands as a pivotal mechanism in defending against oxidative stress damage and related inflammation. Blocking the Keap1-Nrf2 protein-protein interaction (PPI) offers a promising therapeutic approach for treating diseases related to oxidative stress and inflammation. Our group previously reported NXPZ-2, a naphthalene sulfonamide derivative targeting Keap1, which effectively inhibits the Keap1-Nrf2 PPI, thereby releasing Nrf2 to exert its anti-inflammatory and antioxidant effects.

Strategic crossing decisions in vehicle interactions at uncontrolled intersections: A networked driving simulator study.

At uncontrolled intersections, without traffic signals or explicit right-of-way guidance, drivers interacting from different directions depend on their perception and real-time judgment to make strategic decisions about when and how to cross or yield. This uncertainty in decision-making, if misjudged, may result in vehicle collisions. In this study, we developed a networked two-vehicle driving simulator platform, conducted experiments to simulate the interaction between straight-going (SG) and left-turn (LT) vehicles at uncontrolled intersections, and focused on exploring the contributing factors that may influence drivers' crossing decisions.

Conditioned medium of engineering macrophages combined with soluble microneedles promote diabetic wound healing.

Diabetic wounds have a profound effect on both the physical and psychological health of patients, highlighting the urgent necessity for novel treatment strategies and materials. Macrophages are vital contributors to tissue repair mechanisms. Macrophage conditioned medium contains various proteins and cytokines related to wound healing, indicating its potential to improve recovery from diabetic wound.

Personalized Dual-Level Color Grading for 360-degree Images in Virtual Reality.

The rising popularity of 360-degree images and virtual reality (VR) has spurred a growing interest among creators in producing visually appealing content through effective color grading processes. Although existing computational approaches have simplified the global color adjustment for entire images with Preferential Bayesian Optimization (PBO), they neglect local colors for points of interest and are not optimized for the immersive nature of VR. In response, we propose a dual-level PBO framework that integrates global and local color adjustments tailored for VR environments.