Publications by authors named "Jipan Liu"
System biology analysis of miRNA-gene interaction network reveals novel drug targets in breast cancer.
Nucleosides Nucleotides Nucleic Acids
December 2024
Article Synopsis
- Breast cancer is a complex disease that is very common globally, and while some treatments exist, there's a pressing need to find better drug targets.
- This study analyzed six sequencing datasets from the GEO database, identifying 67 miRNAs and 133 genes that are differentially expressed in breast cancer, and constructed a miRNA-gene interaction network.
- Among the identified molecules, three miRNAs were found to significantly impact patient prognosis, leading researchers to propose four potential drug candidates for targeted therapy in breast cancer treatment.
Article Synopsis
- Mesenchymal stem cells (MSCs) have potential in cancer therapies due to their ability to modulate the immune response and aid in tissue regeneration, particularly in colorectal cancer (CRC).
- However, MSCs can have conflicting effects, as they may inhibit cancer growth in some cases while promoting tumor progression in others.
- Recent studies suggest that exosomal microRNAs (Exo-miRs) from MSCs play a crucial role in this dual behavior, highlighting their potential for both understanding CRC progression and developing treatment options.
Background: Circular RNAs (circRNAs) have been shown to exert vital functions in colorectal cancer (CRC) development. However, the role of circ_0067717 in CRC progression remains to be elucidated.
Methods: The expression of circ_0067717, microRNA (miR)-497-5p and solute carrier family 7 member 5 (SLC7A5) was analyzed by quantitative real-time PCR.
[Sanshensancao mixture alleviates the histologic injury and reduces the level of inflammatory factors of colonic mucosa in rats with ulcerative colitis].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
October 2018
Objective To investigate the effect of sanshensancao mixture on the histologic injury of colonic mucosa and the level of IL-12P70, TNF-α and IFN-γ in rats with ulcerative colitis(UC). Methods The rats were randomly divided into control group, model group and sanshensancao mixture group, with 10 rats in each group. The control group was fed with conventional diet, the sanshensancao mixture group and model group were established UC model by sodium trinitrobenzene sulfonate(TNBS)-ethanol induction method.
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