Publications by authors named "Jiou Zhao"
Pediatric Acute Lymphoblastic Leukemia (ALL) is the most common malignant tumor of the hematological system in children, and its relapse after treatment has consistently been a significant factor hindering prognosis. This study aimed to develop a blood-based non-invasive method for predicting relapse in children with ALL. Two cohorts of pediatric ALL patients were analyzed.
View Article and Find Full Text PDFArticle Synopsis
- A previous study identified the WWOX gene as a risk factor for developing acute lymphoblastic leukemia (ALL), leading to deeper genetic analysis of the disease using a sample of 269 cases and 1039 controls from Chinese descent.
- The analysis revealed that the serotonin-activated cation-selective channel complex gene-set plays a significant role in ALL, with the T allele of rs33940208 linked to a lower risk of developing the disease, and the A allele of rs6779545 associated with a higher risk.
- Combining these genetic variants showed that having multiple risk alleles significantly increases the likelihood of developing childhood ALL, highlighting the need for further research to understand the molecular mechanisms involved and improve prevention strategies.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that commonly affects children and adolescents with a poor prognosis. The terminal unfolded protein response (UPR) is an emerging anti-cancer approach, although its role in pediatric T-ALL remains unclear. In our pediatric T-ALL cohort from different centers, a lower QRICH1 expression was found associated with a worse prognosis of pediatric T-ALL.
View Article and Find Full Text PDFObjective: Acute lymphoblastic leukemia is the most common malignant disease in children. CD34 and CD38 are expressed in both normal and leukemia cells, but studies of their prognostic associations in childhood acute lymphoblastic leukemia are limited. The aim of this study was to investigate the prognostic effect of CD34 CD38 leukemia cells in this childhood cancer.
View Article and Find Full Text PDFBACKGROUND B cell acute lymphoblastic leukemia (B-ALL) is the most common type of ALL. This study aimed to explore risk factors for relapse of childhood B-ALL. MATERIAL AND METHODS Total of 102 pediatric B-ALL patients were included in this study.
View Article and Find Full Text PDF[Expression of CCR7 and Tim-3 in Childhood Patients with Acute Lymphoblastic Leukemia and Their Predictive Value for Prognosis].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2019
Objective: To analyze the expression of CCR7 and Tim-3 in childhood patients with acute lymphoblastic leukemia (ALL) and their predictive value for prognosis.
Methods: Eighty-six newly diagnosed ALL childhood patients from January 2007 to January 2017 treated in our hospital were selected. The expression level of CCR7 and Tim-3 in bone marrow isolated cells of ALL patients were detected by flow cytometry, all the patients were divided into the recurrence group and non-recurrence group according to the follow-up results, the differences in the expressions of CCR7, Tim-3 between the two groups were compared.
[Expression of Wif-1 and β-catenin in the Wnt pathway in childhood acute lympho-blastic leukemia].
Zhongguo Dang Dai Er Ke Za Zhi
September 2016
Objective: To investigate the expression and possible roles of Wnt inhibitory factor-1 (Wif-1) and β-catenin in the Wnt pathway in childhood acute lymphoblastic leukemia (ALL).
Methods: The clinical data of 35 children who had newly-diagnosed ALL and achieved complete remission on day 33 of remission induction therapy were retrospectively reviewed. The children before treatment were considered as the incipient group, and those who achieved complete remission on day 33 were considered as the remission group.