SPP-CPI: Predicting Compound-Protein Interactions Based On Neural Networks.

Identifying interactions between compound and protein is a substantial part of the drug discovery process. Accurate prediction of interaction relationships can greatly reduce the time of drug development. The uniqueness of our method lies in three aspects:1) it represents a compound with a distance matrix.

protein2vec: Predicting Protein-Protein Interactions Based on LSTM.

The semantic similarity of gene ontology (GO) terms is widely used to predict protein-protein interactions (PPIs). The traditional semantic similarity measures are based mainly on manually crafted features, which may ignore some important hidden information of the gene ontology. Moreover, those methods usually obtain the similarity between proteins from similarity between GO terms by some simple statistical rules, such as MAX and BMA (best-match average), oversimplifying the possible complex relationship between the proteins and the GO terms annotated with them.

Alignment-Free Sequence Comparison With Multiple k Values.

Alignment-free sequence comparison approaches have become increasingly popular in computational biology, because alignment-based approaches are inefficient to process large-scale datasets. Still, there is no way to determine the optimal value of the critical parameter k for alignment-free approaches in general. In this article, we tried to solve the problem by involving multiple k values simultaneously.

An improved approach to infer protein-protein interaction based on a hierarchical vector space model.

Background: Comparing and classifying functions of gene products are important in today's biomedical research. The semantic similarity derived from the Gene Ontology (GO) annotation has been regarded as one of the most widely used indicators for protein interaction. Among the various approaches proposed, those based on the vector space model are relatively simple, but their effectiveness is far from satisfying.