Percutaneous cement-augmented short-segment pedicle screw fixation plus percutaneous vertebroplasty for stage III Kummell's disease without neurological symptoms: A case report.

Introduction: The incidence of stage III Kummell's disease without neurological symptoms is increasing in elderly patients with osteoporotic thoracolumbar fractures. However, the surgical method is still controversial in this condition. This report presented a case of Kummell's disease in which percutaneous bone cement-augmented short-segment pedicle screw fixation combined with percutaneous vertebroplasty was performed, providing a reference for the surgical approach.

The hypertrophy of the cervical ligamentum flavum results in incomplete paralysis of both lower limbs: A case report.

Introduction: The occurrence of cervical spinal stenosis caused by single-segment hypertrophic folds of the non-calcified ligamentum flavum (LF) at a single level is exceedingly rare, with previous surgical interventions predominantly employing posterior approaches and open procedures. This case report presents an exceptional instance wherein a patient achieved satisfactory outcomes following endoscopic surgery, thereby furnishing valuable evidence supporting the feasibility of endoscopic treatment for cervical LF hypertrophy.

Case Presentation: The patient, a 66-year-old male, presented to our hospital with chronic cervical pain, bilateral lower limb weakness, and gait instability.

Ionizing Radiation Induces Disc Annulus Fibrosus Senescence and Matrix Catabolism via MMP-Mediated Pathways.

Previous research has identified an association between external radiation and disc degeneration, but the mechanism was poorly understood. This study explores the effects of ionizing radiation (IR) on inducing cellular senescence of annulus fibrosus (AF) in cell culture and in an in vivo mouse model. Exposure of AF cell culture to 10-15 Gy IR for 5 min followed by 5 days of culture incubation resulted in almost complete senescence induction as evidenced by SA-βgal positive staining of cells and elevated mRNA expression of the p16 and p21 senescent markers.

Effects of suppressing bioavailability of insulin-like growth factor on age-associated intervertebral disc degeneration.

Suppression of the insulin-like growth factor-1 (IGF-1) signaling pathway reduces age-related disorders and increases lifespan across species, making the IGF-1 pathway a key regulator of aging. Previous in vitro intervertebral disc cell studies have reported the pro-anabolic effect of exogenously adding IGF-1 on matrix production. However, the overall effects of suppressing IGF-1 signaling on age-related intervertebral disc degeneration (IDD) is not known.