People in relationally mobile cultures report higher well-being.

In cultures with high relational mobility, relationships are free and flexible. People can make new friends easily, and they have the freedom to leave unsatisfying relationships. In cultures with low relational mobility, relationships are more fixed, and people have less freedom to leave relationships.

The Impact of the Pneumatic Logistics Transmission System + Intelligent Robot on Blood Routine and Coagulation Function Test Outcomes.

Background: The implementation of intelligent logistics transmission systems signifies a key aspect of modernizing hospital logistics systems in today's healthcare infrastructure. The pneumatic logistics transmission system (PTS) represents a sophisticated solution for the swift and secure conveyance of medical documents, specimens, and pharmaceuticals within hospital premises.

Objective: This study investigates the influence of integrating the 'pneumatic logistics transmission system + intelligent robot' on blood routine and coagulation function test outcomes.

Investigation of Flexural Bearing Behavior of Corroded RC Strengthened with U-Type TRC.

In this study, the flexural bearing behavior of corroded reinforced concrete (RC) beams reinforced with U-type Textile Reinforced Concrete (TRC) was investigated using a four-point bending loading method. Nine test beams were produced: one original beam, three RC beams with corrosion alone, and five corroded beams strengthened with U-type TRC. The analysis focuses on assessing the impacts of the steel corrosion degree and the number of textile layers on various aspects of the bending behavior, such as failure modes, bearing capacity, and load displacement curves, in U-type TRC-strengthened corroded beams.

Traditional Chinese medicine Qingre Huoxue decoction enhances wound healing in through modulation of angiogenic and inflammatory pathways.

This study investigates the therapeutic potential of Qingre Huoxue Decoction (QHD), a traditional Chinese herbal formulation, in promoting wound healing in an imiquimod-induced murine model of psoriasis. The research was driven by the need for effective wound healing strategies in psoriatic conditions, where conventional treatments often fall short. Employing a combination of in vivo and in vitro methodologies, we assessed the effects of QHD on key factors associated with wound healing.

Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs.

Spinal cord injury (SCI) is an unfortunate experience that may generate extensive sensory and motor disabilities due to the destruction and passing of nerve cells. MicroRNAs are small RNA molecules that do not code for proteins but instead serve to regulate protein synthesis by targeting messenger RNA's expression. After SCI, secondary damage like apoptosis, oxidative stress, inflammation, and autophagy occurs, and differentially expressed microRNAs show a function in these procedures.

Identification of Peptides of Small Extracellular Vesicles from Bone Marrow-Derived Macrophages.

Small extracellular vesicles (sEVs) are typically secreted by the exocytosis of multivesicular bodies (MVBs). These nanovesicles with a diameter of <200 nm are present in various body fluids. These sEVs regulate various biological processes such as gene transcription and translation, cell proliferation and survival, immunity and inflammation through their cargos, such as proteins, DNA, RNA, and metabolites.

A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals.

Aim: Caffeinated beverages are very popular across populations and cultures, but quantitative evidence of the acute effects of moderate coffee doses on retinal perfusion is sparse and contradicting. Thus, the aim of this randomized, cross-over and parallel-group design study was to investigate whether moderate consumption of coffee alters macular retinal capillary perfusion in young healthy individuals.

Methods: Twenty-seven young healthy individuals were recruited for this study.

[Analysis on the Quality Status of in Vitro Diagnostic Reagents for National Medical Device Supervision and Inspection in 2020].

Objective: This paper puts forward suggestions on the development of diagnostic reagents and supervision measures for the post-marketing products, so as to further improve the quality of diagnostic reagents and ensure the safety use of medical device.

Methods: This paper summarizes the quality of diagnostic reagents and analyzes the causes of the problems, according to the results of the national medical device supervision and inspection in 2020.

Results: The overall quality of diagnostic reagents for national medical device supervision and inspection in 2020 is stable and the unqualified detection rate is 1.

[Analysis on the Characteristics of Quality Variation of National Medical Device Supervision and Inspection in 2020].

This study is based on the summary of the characteristics of quality variation of national medical device supervision and inspection in 2020. According to the results of the national medical device supervision and inspection through comparative analysis, this study puts forward suggestions on the medical device production and supervision measures for the post-marketing products, so as to further improve the level of the medical device and ensure the safety use of medical device.

Ginsenoside Rg1 ameliorates psoriasis-like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes.

As a common chronic skin disease, psoriasis is characterized by the involvement of congenital acquired inflammatory immune diseases. In the study, our results indicated the effect of ginsenoside Rg1 on psoriasis-like skin and the potential protection mechanisms that have not yet been investigated. In vivo, psoriasis-like skin mice model was induced by imiquimod (IMQ), then was treated by ginsenoside Rg1 for consecutive 4 weeks to evaluate its effect, respectively.

Successful treatment after toxic epidermal necrolysis induced by AZD-9291 in a patient with non-small cell lung cancer: A case report.

Background: Toxic epidermal necrolysis and Stevens-Johnson syndrome are acute life-threatening skin reactions. AZD9291 has been developed as a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) with activity against T790M mutation.

Case Summary: Herein we report a 68-year-old woman who developed a large area of skin necrosis and was diagnosed with toxic epidermal necrolysis after AZD-9291 ingestion.

Relationship between rice farming and polygenic scores potentially linked to agriculture in China.

Following domestication in the lower Yangtze River valley 9400 years ago, rice farming spread throughout China and changed lifestyle patterns among Neolithic populations. Here, we report evidence that the advent of rice domestication and cultivation may have shaped humans not only culturally but also genetically. Leveraging recent findings from molecular genetics, we construct a number of polygenic scores (PGSs) of behavioural traits and examine their associations with rice cultivation based on a sample of 4101 individuals recently collected from mainland China.

[Analysis of Quality Status of National Medical Device Supervision and Inspection in 2019].

Summarize the quality status and variety quality change characteristics of the sampling products through the Summary and analysis, according to the results of the national medical device supervision and inspection in 2019. Put forward suggestions on the development of the medical device industry and supervisory measures. Thereby, further improve the level of the medical device and ensure the safety use of medical device.

Computed Tomography Angiography of Gastrocolic Vein Trunk by Morphological Filtering Technique in Right Colon Cancer.

Background: This study was to evaluate CT vein image segmentation and three-dimensional imaging in the anatomical structure of gastrocolic venous trunk before operation for colon cancer.

Methods: CT scanning images by Philips Brilliance CT 256CT scanner. Vein position was segmented and calculated by grey value through algorithm flow.

[Establishment of Sampling Inspection Scheme Paradigm for Medical Device Sampling Inspection].

This paper introduces the sampling scheme and the inspection scheme paradigm followed in organizing the sampling inspection of medical devices. The sampling scheme paradigm includes the definition and operation guidelines for sampling products, the regulations for individual sampling batches and related model specifications, accessory data, validity period, storage conditions, etc., the requirements for sampling areas, places and quantities, and the requirements for samples to be sent to inspection institutions.

[Risk Point Analysis of Product Quality and Safety in Sample Inspection of National Medical Device Supervision].

This paper reviews the quality and safety risk points of medical devices found in the sampling inspection of national medical device supervision in recent years. These risk points are summarized into quality management system, product technical requirements, national standards and industry standards, etc. Several specific risk scenarios are further summarized.

[Analysis of Variety Selection for Medical Device Supervision and Inspection].

This article introduces the process and principles of variety selection for medical device supervision and inspection, and it analyzes the reason and consideration of the variety selection data of national medical device supervision and inspection from 2017 to 2019, it also put forward a collection of selected varieties for reference in the future by sorting out the classified catalogue of medical devices and diagnostic reagents.

A Novel Magnetic Contrast Agent for Gastrointestinal Mucosa-Targeted Imaging Through Oral Administration.

The development of functional contrast agents for diagnosis and therapy of functional gastrointestinal disorders has been a focus of research in recent years. Owing to the excellent distribution and function of 5-HT3 in gastrointestinal mucosa, a novel magnetic contrast agent (AH-CTS-Gd nanosphere) was prepared based on chitosan and 5-HT3 receptors, which realize multifunctional assessment of gastric emptying and gastrointestinal mucosa-targeted MR imaging. The obtained AH-CTS-Gd nanosphere was administered orally to avoid potential toxicity from intravenous administration of a high dose.

High T2-weighted signal intensity is associated with myocardial deformation in hypertrophic cardiomyopathy.

The association between global and segmental myocardial strain impairment and fibrosis extent in hypertrophic cardiomyopathy (HCM) is widely verified. The aim of this study was to investigate the contribution of high T2-weighted signal intensity (HighT2) to myocardial deformation in HCM. We prospectively recruited 57 patients with HCM examined by a 3.

Dual Energy Spectral CT Imaging in the assessment of Gastric Cancer and cell proliferation: A Preliminary Study.

Gastric cancer is one of the main diseases leading to cancer-related death. The recently introduced dual-energy spectral CT (DEsCT), allows to obtain many quantitative measurements from iodine-based material decomposition (MD) images, which contribute to improve the accuracy of staging of GC comparing to multidetector spiral CT. And Ki-67 is a well-recognized nuclear antigen-specific biomarker reflecting cellular proliferation for estimating growth fractions of various tumor types.

Creeping fat in patients with ileo-colonic Crohn's disease correlates with disease activity and severity of inflammation: A preliminary study using energy spectral computed tomography.

Objective: To investigate the relationship between creeping fat and inflammatory activity as well as the prognosis of ileo-colonic Crohn's disease (CD), based on a quantitative analysis of energy spectral computed tomography (CT).

Methods: A total of 40 patients with CD and 40 with other gastrointestinal diseases who underwent an energy spectral CT scanning between March 2014 and March 2015 were retrospectively enrolled. The endoscopic severity of CD was evaluated by the simple endoscopic score for Crohn's disease (SES-CD).

[Analysis of Quality Status of National Medical Device Supervision and Inspection from 2013 to 2016].

In this paper, we analyze the status of the medical device testing and the situation of the unqualifie varieties by sorting out the situation of the national medical device supervision and inspection from 2013 to 2016. We analyze the results of the inspection deeply, and find that the safety risk points exists in the quality of the medical device testing products and management system, product technology requirements, the national standards, industry standards or other aspects, then explain one by one with typical examples. At the same time the corresponding suggestions are put forward to production companies and regulators respectively on the existing problems.

[Analysis of Changing the Original Test Result after Retesting in National Medical Device Sampling and Testing from 2013 to 2016].

The types and the reasons of changing the original test result after retesting in national medical device sampling and testing from 2013 to 2016, are summarized and analyzed. Firstly, collecting data of "standards not complied" and retesting. Then, giving specific examples when summarizing five types of changing the original test result after retesting.

Differentiation of cancerous and inflammatory colorectal perforations using multi-detector computed tomography.

Purpose: To determine reliable CT features to distinguish cancerous from inflammatory colorectal perforations.

Materials And Methods: A total of 43 patients with surgically and pathologically confirmed colorectal perforation caused by either colorectal cancer (n =27) or an inflammatory conditions (n = 16) were identified. Two radiologists independently assessed the contrast-enhanced CT features for locations of perforation, mural configurations, soft-tissue alterations, lymphadenopathy, and metastases.

Usefulness of spectral computed tomography for evaluation of intestinal activity and severity in ileocolonic Crohn's disease.

Background: Assessment of intestinal activity and severity of Crohn's disease (CD) is crucial to guide treatment. In this study, we aimed to investigate the accuracy of spectral computed tomography (CT) in this assessment and make a comparison with conventional CT.

Methods: A total of 50 patients with ileocolonic CD underwent spectral CT scanning.