Publications by authors named "Jiong Li"

Background: As a class of synthetic chemicals, organophosphate esters (OPEs) were shown to have thyroid hormones (THs) disrupting potentials in animal studies, while epidemiological evidence on gestational exposure to OPEs and thyroid disruption is limited. Besides, assessment on the safety threshold of OPEs exposure during gestation is especially scarce.

Methods: Based on the Shanghai Minhang Birth Cohort Study, we measured maternal urine concentration of 8 OPE metabolites and THs levels in cord plasma and examined their associations using multiple linear regression and quantile g-computation (QGC) models.

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The skin serves as the first protective barrier for nonspecific immunity and encompasses a vast network of skin-associated immune cells. Atopic dermatitis (AD) is a prevalent inflammatory skin disease that affects individuals of all ages and races, with a complex pathogenesis intricately linked to genetic, environmental factors, skin barrier dysfunction as well as immune dysfunction. Individuals diagnosed with AD frequently exhibit genetic predispositions, characterized by mutations that impact the structural integrity of the skin barrier.

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  • Bisphenol A (BPA) is an endocrine disruptor that negatively impacts the nervous system, leading to anxiety-like behavior and cognitive impairments in mice.
  • This study investigates whether an enriched environment (EE) can counteract these effects by enhancing cognitive behavior and reducing anxiety in mice exposed to BPA.
  • Results showed that EE treatment improves dendritic spine development, restores excitatory synaptic transmission, and alleviates behavioral issues associated with BPA exposure, highlighting the neuroprotective role of EE.
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  • - Children born to mothers with polycystic ovary syndrome (PCOS) show a greater likelihood of developing cardiovascular risk factors and subclinical cardiovascular disease compared to those born to mothers without PCOS.
  • - A large cohort study in Denmark and Sweden, tracking over 6 million live births, reveals that offspring of mothers with PCOS have an increased risk of cardiovascular diseases, regardless of other health conditions.
  • - The study's results suggest that if confirmed by further research, there may be a need for early cardiovascular prevention strategies for children born to women with PCOS.
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All-inorganic perovskites prepared by substituting the organic cations (e.g. methylammonium (MA) and formamidinium (FA)) with inorganic cations (e.

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  • The study developed an intranasal COVID-19 vaccine called RBD-HR, which consists of a receptor binding domain-derived protein and a special oil-in-water adjuvant for enhanced immune response.
  • Testing in mice and rats showed that the vaccine generated strong and long-lasting immune responses, producing high levels of neutralizing antibodies against specific SARS-CoV-2 variants for at least six months.
  • Additionally, the intranasal administration of the vaccine resulted in effective mucosal and systemic immunity, and when used as a booster after mRNA vaccines, it provided better immune responses and protection against live virus challenges.
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  • This study evaluates how to effectively transition from age-specific to size-specific dose protocols in pediatric head CT scans for better safety and efficacy.
  • It uses existing age-specific dose protocols for children aged 1 to 6 years (21.34 mGy) and those older than 6 (34.73 mGy), assessing different size groups based on head diameter.
  • Findings indicate that children in one group may have received excessive radiation (38% more than needed), highlighting the importance of tailoring doses based on size rather than just age.
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Introduction: Photodynamic therapy (PDT) has attracted increasing attention in the clinical treatment of epidermal and luminal tumors. However, the PDT efficacy in practice is severely impeded by tumor hypoxia and the adverse factors associated with hydrophobic photosensitizers (PSs), including low delivery capacity, poor photoactivity and limited ROS diffusion. In this study, Pt nanozymes decorated two-dimensional (2D) porphyrin metal-organic framework (MOF) nanosheets (PMOF@HA) were fabricated and investigated to conquer the obstacles of PDT against hypoxic tumors.

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  • - Strong metal-support interactions (SMSI) help stabilize very small metal sites (sub-2 nm) like single atoms or clusters, but optimizing these sites to improve both activity and stability is challenging.
  • - The study introduces a new approach combining SMSI with reactive metal-support interactions (RMSI) to optimize the performance of nickel (Ni) clusters, resulting in the formation of a specific metal phosphide cluster (Ni2Pn).
  • - This synergistic approach enhances the catalytic activity of Ni2Pn for selective hydrogenations, achieving product formation rates that are significantly higher than those for the other nickel sites tested.
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  • Soluble factors in the upper respiratory tract, specifically a protease called HAT, can help defend against SARS-CoV-2 by reducing its infectivity through cleavage of the virus's spike protein.
  • In studies, infected mice showed increased levels of HAT, which effectively blocked the virus's ability to attach to and fuse with host cells.
  • However, HAT was found to be less effective against the Delta and certain Omicron variants due to mutations near the cleavage site that rendered it resistant.
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Background: It remains unclear which early gestational biomarkers can be used in predicting later development of gestational diabetes mellitus (GDM). We sought to identify the optimal combination of early gestational biomarkers in predicting GDM in machine learning (ML) models.

Methods: This was a nested case-control study including 100 pairs of GDM and euglycemic (control) pregnancies in the Early Life Plan cohort in Shanghai, China.

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It has been demonstrated that the KDM3 family of histone demethylases (KDM3A and KDM3B) epigenetically control the functional properties of colorectal cancer stem cells (CSCs) through Wnt/β-catenin signaling. Meanwhile, a broad-spectrum histone demethylase inhibitor, IOX1, suppresses Wnt-induced colorectal tumorigenesis predominantly through inhibiting the enzymatic activity of KDM3. In this work, several cereblon (CRBN)-recruiting PROTACs with various linker lengths were designed and synthesized using IOX1 as a warhead to target KDM3 proteins for degradation.

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Background: Both body mass index (BMI) and genetic factors independently contribute to cardiovascular disease (CVD). However, it is unclear whether genetic risk modifies the association between BMI and the risk of incident CVD. This study aimed to investigate whether BMI categories and genetic risk jointly and interactively contribute to incident CVD events, including hypertension (HTN), atrial fibrillation (AF), coronary heart disease (CHD), stroke, and heart failure (HF).

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  • Damage to oligodendrocytes and myelin sheaths is linked to various neurological and psychiatric disorders, making remyelination a critical process in the central nervous system.
  • Recent research suggests that oligodendrocyte progenitor cells (OPCs) play a key role in remyelination, rather than mature oligodendrocytes.
  • A study using mice with a specific knock-out of the Myrf gene, which is crucial for OPC differentiation, revealed significant impairments in remyelination and behavioral deficits, reinforcing the importance of OPCs in myelin regeneration for treating demyelinating diseases.
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Dysregulation of splicing factor expression plays a crucial role in the progression of hepatocellular carcinoma (HCC). Our research found that the expression level of splicing factor ZMAT2 was increased in HCC, promoting the proliferation of HCC cells. RNAseq data indicated that the absence of ZMAT2 induced skipping exon of mRNA, while RIPseq data further revealed the mRNA binding motifs of ZMAT2.

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  • - The study focuses on creating a new cancer vaccine by engineering mitochondria to enhance antigen delivery, specifically using proteins like ovalbumin (OVA) and tyrosinase-related protein 2 (TRP2) to stimulate the immune system against tumors.
  • - Engineered vaccines with OVA and TRP2 were effective in activating dendritic cells (DCs) and inducing a tumor-specific immune response in mice, highlighting their potential as both preventive and therapeutic options.
  • - The research reveals that the activation of DCs via these mitochondrial vaccines utilizes the TLR2 pathway, suggesting these engineered mitochondria could be a versatile tool for developing vaccines for various cancers and diseases.
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Protein-based detection methods, enzyme-linked immunosorbent assays (ELISAs) and lateral flow strips, have been widely used for rapid, specific, and sensitive detection of genetically modified organisms (GMOs). However, the traditional ELISA method for the quantitative detection of GMOs has certain limitations. Herein, a quantum dot (QD)-based fluorescence-linked immunosorbent assay was developed using QDs as fluorescent markers for the detection of glyphosate-resistant protein (CP4-EPSPS) in the MON89788 soybean.

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Ligand-to-metal charge transfer (LMCT) is conceived as a universal theory to account for voltage hysteresis in oxygen-redox battery electrodes. However, the influence of oxygen anionic species on mediating LMCT and its reflection to voltage hysteresis remain poorly understood. Herein, we demonstrate a close interplay between the chemical states of oxidized oxygen species, the cationic species, and the kinetics of LMCT and forcefully identify their influence on the magnitude of voltage hysteresis.

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While maternal exposure to high metal levels during pregnancy is an established risk factor for birth defects, the role of paternal exposure remains largely unknown. We aimed to assess the associations of prenatal paternal and maternal metal exposure and parental coexposure with birth defects in singletons. This study conducted within the Jiangsu Birth Cohort recruited couples in early pregnancy.

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Precise control over the size, species, and breakthrough of the activity-selectivity trade-off are great challenges for sub-nano non-noble metal catalysts. Here, for the first time, a "multiheteroatom induced SMSI + in situ P activation" strategy that enables high stability and effective construction of sub-2 nm metal sites for optimizing selective hydrogenation performance is developed. It is synthesized the smallest metal phosphide clusters (<2 nm) including from unary to ternary non-noble metal systems, accompanied by unprecedented thermal stability.

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