Publications by authors named "Jiong Dang"
A Novel Mutation Located in the N-Terminal Domain of MYO15A Caused Sensorineural Hearing Loss.
Mol Genet Genomic Med
December 2024
Article Synopsis
- MYO15A gene mutations are linked to severe sensorineural deafness, impacting those both before and after they acquire language, with a novel mutation (c.2482C>T) found in a Chinese Uighur family identified in this study.* -
- Researchers created induced pluripotent stem cells (iPSCs) from family members to explore how the MYO15A mutation affects hair cell-like cells, which are important for hearing.* -
- The findings revealed that the mutation caused noticeable differences in the structure and function of these cells, indicating a possible link to hearing loss, while not affecting the iPSCs' ability to become different cell types.*
Background: Congenital sensorineural hearing loss is a common congenital condition.
Objectives: The purpose of this study was to assess the correlation between nonverbal mental development and the effect of post-cochlear implant in children.
Material And Methods: The study is a retrospective analysis of the CI program implemented at the ENT in the Lanzhou University Second Hospital (China).