Study on the failure and acoustic emission characteristics of coal under graded cyclic loading and unloading stress paths.

To study the influence of cyclic disturbance stress on the mechanical behavior of coal during mining, a gas containing coal fluid-solid coupling servo seepage experimental system was used to conduct experimental research on the acoustic emission (AE) characteristics of gas containing coal under two stress paths of graded cyclic loading and unloading. The AE characteristics of coal damage and failure processes under different cyclic stress paths were analyzed. The research results indicate that: (1) The overall characteristics of AE signals for both graded cyclic loading and unloading paths are basically the same.

Discussion on Health Service System of Mobile Medical Institutions Based on Internet of Things and Cloud Computing.

Because modern human beings pay more and more attention to physical health, and there are many problems in the traditional medical service system, human beings have a higher and higher voice for the new medical model. At present, there are many researches on the application of modern science and technology to put forward solutions to medical development, but they generally pay attention to some details and ignore the construction of the whole medical service system. In order to solve the problems of low efficiency of the traditional medical model, difficult communication between doctors and patients, unreasonable allocation of medical resources, and so on, this article proposes establishing a perfect medical and health service system.

MicroRNA-29b-3p enhances radiosensitivity through modulating WISP1-mediated mitochondrial apoptosis in prostate cancer cells.

Radiotherapy is frequently applied for clinically localized prostate cancer while its efficacy could be significantly hindered by radioresistance. MicroRNAs (miRNAs) are important regulators in mediating cellular responses to ionizing radiation (IR), and strongly associate with radiosensitivity in many cancers. In this study, enhancement of radiosensitivity by miR-29b-3p was demonstrated in prostate cancer cell line LNCaP .

Exogenous melatonin modulates carbon ion radiation-induced immune dysfunction in mice.

In spite of carbon ion radiotherapy is a talented modality for malignant tumor patients, the radiation damage of normal tissues adjacent to tumor and the dysfunction of immune system limits therapeutic gain. Protecting immune system against carbon ion radiation-caused damage has the possibility to improve cancer treatment, but it is uncertain whether conventional radioprotective agents play a role in carbon ion radiation. To certify carbon ion caused immune dysfunction and assess the radioprotective effect of melatonin on immune system, animal experiments were performed in radiosensitive BALB/C mice.

[Screening of nucleic acid aptamer of lung cancer cells based on cell exponential enrichment ligand system evolution and its application in tumor diagnosis and treatment].

Nucleic acid aptamer is an oligonucleotide sequence screened by the exponential enrichment ligand system evolution technology (SELEX). Previous studies have shown that nucleic acid aptamer has a good application prospect in tumor diagnosis and treatment. Therefore, we reviewed the selection and identification of nucleic acid aptamer of lung cancer cells in recent years, and discussed the effect of aptamer as targeting drugs and targeting vectors on the diagnosis of tumors, which provide a new idea for early diagnosis and treatment of tumor.

microRNA-16-5p enhances radiosensitivity through modulating Cyclin D1/E1-pRb-E2F1 pathway in prostate cancer cells.

Prostate cancer (CaP) is the second most common cancer in men worldwide in 2012, and radiation therapy is one of the most common definitive treatment options for localized CaP. However, radioresistance is a major challenge for the current radiotherapy, accumulating evidences suggest microRNAs (miRNAs), as an important regulator in cellular ionizing radiation (IR) responses, are closely correlated with radiosensitivity in many cancers. Here, we identified microRNA-16-5p(miR-16-5p) is significantly upregulated in CaP LNCaP cells following IR and can enhance radiosensitivity through modulating Cyclin D1/E1-pRb-E2F1 pathway.

Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis.

Nuclear factor E2 related factor 2 (Nrf2) is a transcription factor that is associated with tumor growth and resistance to radiation. The canonical Notch signaling pathway is also crucial for maintaining non-small cell lung cancer (NSCLC). Aberrant Nrf2 and Notch signaling has repeatedly been showed to facilitate metastasis of NSCLC.

Dicranostiga leptopodu (Maxim.) Fedde extracts attenuated CCl-induced acute liver damage in mice through increasing anti-oxidative enzyme activity to improve mitochondrial function.

Dicranostiga Leptodu (Maxim.) fedde (DLF), a poppy plant, has been reported have many benefits and medicinal properties, including free radicals scavenging and detoxifying. However, the protective effect of DLF extracts against carbon tetrachloride (CCl)-induced damage in mice liver has not been elucidated.