Individualised acute normovolaemic haemodilution for non-cardiac surgery with anticipated high-dose red cell transfusion: study protocol for a randomised controlled trial in West China Hospital of Sichuan University.

Introduction: Acute normovolaemic haemodilution (ANH) is a perioperative blood management technique involving the removal of whole blood and simultaneous infusion of colloids or crystalloids to achieve haemodilution while maintaining normovolaemia. However, its efficacy in reducing the requirement for perioperative allogeneic blood transfusion remains controversial due to inconsistent findings in the literature. An individualised red cell transfusion strategy, guided by the West China Liu's Score, has demonstrated effectiveness in reducing the need for allogeneic red cell transfusion.

Serological and molecular analysis of the B(A) subtype in China-A systematic review.

Objective: To study the serological and molecular biological characteristics of the B(A) subtype and its geographical distribution in China through case discussion and systematic review.

Methods: A case of the B(A)02 subtype previously found in our laboratory was retrospectively analysed. The distribution characteristics and specific serological and genotypic characteristics of the B(A) subtype in China were systematically evaluated by searching four major Chinese databases.

Identification of a novel FUT1 allele with two mutations in a Chinese para-Bombay individual.

Background: The para-Bombay phenotype often results from a silenced β-D-galactoside 2-α-fucosyltransferase 1 (FUT1) gene (h/h) but an active FUT2 (Se/Se or Se/se) gene. We identified a para-Bombay phenotype with two novel mutations in the FUT1 gene and homozygous mutated FUT2 (se /se ) genes.

Study Design And Methods: Red blood cell phenotype was detected by using a standard serologic technique.

Unexpected red blood cell antibody distributions in Chinese people by a systematic literature review.

Background: Unexpected antibodies are frequently associated with hemolytic disease of the fetus and newborn (HDFN) and hemolytic transfusion reactions (HTRs), and screening for those unexpected antibodies is critical for the safety and effectiveness of transfusion. Different populations differ in the prevalence of significant antibodies and also the low-frequency red blood cell (RBC) antigens. In China, antibody screening has been a common practice for pretransfusion testing for more than 10 years.