Data-Driven Multi-Objective Optimization Approach to Loaded Meshing Transmission Performances for Aerospace Spiral Bevel Gears.

Loaded meshing transmission performance optimization has been an increasingly significant target for the design and manufacturing of aerospace spiral bevel gears with low noise and high strength. An innovative data-driven multi-objective optimization (MOO) method is proposed for the loaded meshing transmission performances of aerospace spiral bevel gears. Data-driven tooth surface modeling is first used to obtain a curvature analysis of loaded contact points.

Towards Understanding Subsurface Characteristics in Burn Process of Gear Profile Grinding.

In gear profile grinding, the grinding burn will greatly influence the anti-fatigue performance of gears. However, the influence of microstructure change caused by grinding burn on gear surface integrity is still unclear. In this paper, full-factor experiments of gear profile grinding are conducted and the grinding temperature is measured during the experiments.

Downregulation of miRNA-155-5p contributes to the adipogenic activity of 2-ethylhexyl diphenyl phosphate in 3T3-L1 preadipocytes.

2-Ethylhexyl diphenyl phosphate (EHDPP) is a commonly used organophosphorus flame retardant and food packaging material. Because of its high lipophilic and bioaccumulative properties, adipocytes are the primary target of EHDPP. However, the toxicity of EHDPP on preadipocytes and the potential mechanism have not been fully elucidated.

Simulation and Experimental Verification of Die Quenching Deformation of Aviation Carburized Face Gear.

The tooth width and length of face gear limit control the strength of face gear, and heat treatments are often used to improve the hardness and strength of face gear. However, heat treatments will often cause additional deformations, which will affect the dimensional accuracy of the face gear. In this paper, to effectively control the deformation and ensure the accuracy of the face gear, the finite element method was used to establish the calculation model of the face gear die quenching method, and thus, the influence of die on the gear quenching deformation was analyzed.

An Investigation of the Contact Fatigue Characteristics of an RV Reducer Crankshaft, Considering the Hardness Gradients and Initial Residual Stress.

The crankshaft is one of the core components of a Rotate Vector (RV) reducer. The fatigue life of the RV reducer is severely hindered by fatigue failure on the eccentric cylindrical surface of the crankshaft. The hardness gradients and residual stress in the crankshaft, associated with machining operations, exert an enormous impact on the rolling contact fatigue (RCF).

An Analytical and Experimental Study on Cutting Characteristics and Transient Cutting Force Modeling in Feed Directional Ultrasonic Vibration-Assisted Cutting of High Strength Alloys.

Ultrasonic vibration-assisted cutting (UVC) is progressively being used in machining as it can significantly promote the fabrication process. However, the ultrasonic vibration affecting the cutting process is still controversial. The full-transient cutting process is proposed in this study to analyze the affecting mechanism induced by ultrasonic vibration in the cutting process.

Understanding Effects of Ultrasonic Vibration on Microstructure Evolution in Hot Forming Process via Cellular Automata Method.

Compared with traditional forming technology, ultrasonic vibration-assisted plastic forming technology can improve the forming conditions and obtain better surface quality of the workpiece. However, the mechanism and theory of ultrasonic action have not formed a unified understanding. In this paper, ultrasonic-assisted thermal forming technology is taken as the research object.

A Measurement Solution of Face Gears with 3D Optical Scanning.

Gears are usually measured by the contact metrology method in gear measuring centers or coordinate measuring machines. Recently, three-dimensional (3D) optical scanning, a non-contact metrology method, has been applied in the industry as an advanced measurement technology mainly due to its high efficiency. However, its applications to gears with complicated geometry, such as face gears, are still limited due to its relatively low accuracy and the void of related measurement solutions.

Rough Surface Characterization Parameter Set and Redundant Parameter Set for Surface Modeling and Performance Research.

Among the 26 roughness parameters described in ISO 25178 standard, the parameters used to characterize surface performance in characterization parameter set () lack scientificity and unity, resulting in application confusion. The current comes from empirical selection or small sample experiments, thus featuring low generality. A new method for constructing in rough surfaces is proposed to solve the above issues.

Digital twin modeling for tooth surface grinding considering low-risk transmission performance of non-orthogonal aviation spiral bevel gears.

Low-risk transmission performance including elastic deformation, loaded contact pattern, load distribution and loaded transmission error is of paramount significance to the actual manufacturing for non-orthogonal aviation spiral bevel gears. The advanced digital twin technology is introduced into tooth flank grinding. A new digital twin modeling considering low-risk transmission performances is proposed.

An Efficient Approach to the Five-Axis Flank Milling of Non-Ferrous Spiral Bevel Gears.

Five-axis flank milling has been applied in industry as a relatively new method to cut spiral bevel gears (SBGs) for its flexibility, especially for the applications of small batches and repairs. However, it still has critical inferior aspects compared to the traditional manufacturing ways of SBGs: the efficiency is low, and the machining accuracy may not ensure the qualified meshing performances. To improve the efficiency, especially for cutting non-ferrous metals, this work proposes an approach to simultaneously cut the tooth surface and tooth bottom by a filleted cutter with only one pass.

ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis.

N6-methyladenosine (m6A) is the most commonly occurring internal RNA modification to be found in eukaryotic mRNA and serves an important role in various physiological events. AlkB homolog 5 RNA demethylase (ALKBH5), an m6A demethylase, belongs to the AlkB family of dioxygenases and has been shown to specifically demethylate m6A in RNA, which is associated with a variety of tumors. However, its function in bladder cancer remains largely unclear.

Electrical and Thermal and Self-Healing Properties of Graphene-Thermopolyurethane Flexible Conductive Films.

We fabricated graphene-thermopolyurethane (G-TPU) flexible conductive film by a blending method and systematically investigated the electrical, thermal and self-healing properties of the G-TPU flexible conductive film by infrared light and electricity. The experimental results demonstrate that the G-TPU composite films have good conductivity and thermal conductivity in the appropriate mass content of graphene in the composite film. The composite films have the good electro-thermal and infrared light thermal response performances and electro-thermal response performance is closely related to the mass content of graphene in the composite film, but the infrared light thermal response performance is not.

Simulations and error analysis of the CNC milling of a face gear tooth with given tool paths.

This data article gives the validation files to the article "CNC milling of face gears with a novel geometric analysis" [1]. The data is about the simulation and machining error analysis of the CNC milling of a face gear tooth with given tool paths. It includes four files.

Disequilibrium in MMPs and the tissue inhibitor of metalloproteinases in different segments of the varicose great saphenous vein wall.

Background: Varicose great saphenous veins (VGSVs) are a common disorder with a high incidence, but the pathogenesis is unclear. This study was designed to measure the changes in matrix metalloproteinases (MMPs) and the tissue inhibitor of metalloproteinases (TIMPs) in different segments from VGSV walls to determine the relationship between MMPs, TIMPs expression, and expansion of the venous wall.

Methods: Twenty-one VGSV and 12 normal great saphenous vein (GSV) specimens were collected.

Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma.

Objective: LncARSR (lncRNA Activated in RCC with Sunitinib Resistance, ENST00000424980) is a newly identified lncRNA to promote the sunitinib resistance of renal cell carcinoma (RCC), which may contribute to tumorigenesis and progression. This study aimed to explore the association of lncARSR tagSNPs with the risk and prognosis of RCC.

Methods: In this study, a 2-stage case-control study was performed to evaluate the association between 2 tagging SNPs (rs1417080 and rs7859384) and RCC susceptibility.

Study on contact performance of ultrasonic-assisted grinding surface.

The contact performance of ultrasonic-assisted grinding surface is studied in this paper. An improved simplified model of rough surface profile is proposed to find the microscopic feature parameters, such as the curvature radius of the asperity, which are suitable for contact analysis and calculation. Then a more accurate rough surface contact analysis model is obtained by combining the classical ZMC contact model.

Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis.

Background/aims: Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed to investigate the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on autophagy inhibition and apoptosis induction.

Methods: Bladder cancer cell lines were irradiated with or without chloroquine.

MiR-200c promotes bladder cancer cell migration and invasion by directly targeting RECK.

Background: Increasing evidence suggests that the dysregulation of certain microRNAs plays an important role in tumorigenesis and metastasis. MiR-200c exhibits a disordered expression in many tumors and presents dual roles in bladder cancer (BC). Therefore, the definite role of miR-200c in BC needs to be investigated further.

Dysregulated apoptosis of the venous wall in chronic venous disease and portal hypertension.

Introduction The etiology of varicose veins remains elusive. We hypothesized that abnormal cell cycle events in the vein wall may contribute to changes in the structural integrity, thus predisposing to the development of varicosities. The present study was designed to determine whether or not the same molecular apoptotic pathway exists between great saphenous and splenic veins.

Changes in levels of apoptosis in the walls of different segments of great saphenous varicose veins.

Objective: Disordered programmed cell death may play a role in the development of superficial venous incompetence. We have determined the number of cells undergoing apoptosis and the alterations in the apoptotic level in the wall of different segments of the great saphenous varicose vein.

Methods: Twenty-one varicose great saphenous veins (VGSVs) (varicose group) and 12 normal great saphenous veins (GSVs) (control group) were collected, and the apoptosis level in the upper, middle, and lower segments were immunohistochemically stained with antibodies (anti-Bax and anti-Bcl-xl).

Assessment of apoptotic cells in the wall of thrombophlebitic saphenous vein.

Introduction: Programmed cell death plays a critical role in various physiological processes. In the present study, we investigated its possible pathogenic role in primary varicose veins. We studied histological changes in surgical specimens from thrombophlebitic saphenous veins.

Assessment of immune cells and function of the residual spleen after subtotal splenectomy due to splenomegaly in cirrhotic patients.

Background: The spleen is thought to be central in regulating the immune system, a metabolic asset involved in endocrine function. Overwhelming postsplenectomy infection leads to a mortality rate of up to 50%. However, there is still controversy on performing subtotal splenectomy as treatment of splenomegaly due to portal hypertension in cirrhotic patients.

Comparison of polymerase chain reaction and immunologic methods for the detection of nanobacterial infection in type-III prostatitis.

Objective: To compare the results of polymerase chain reaction (PCR) and immunologic methods for the detection of nanobacteria (NB) in the expressed prostatic secretions (EPSs) of patients with type-III prostatitis.

Methods: In total, 150 patients with type-III prostatitis for whom conventional clinical treatment had failed were selected from September 2009 to April 2010. The EPS of each patient was divided into 3 parts, which were used for PCR analysis, indirect immunofluorescence staining (IIFS), and culture and subsequent indirect immunofluorescence staining (CIIFS).