Background: The potential association between depressive status and the risk of mild cognitive impairment (MCI) remains unclear, especially in the absence of prospective evidence. This study aims to elucidate the impact of either depression score or depression on the risk of MCI using longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS).
Methods: This prospective study included 5,766 participants from CHARLS followed from 2011 to 2015.
Sufu is a traditional Chinese condiment with a distinctive flavor. The umami characteristics are primarily attributed to the hydrolysis of proteins, which produces amino acids and biogenic amines (BAs). Excessive levels of BAs can pose health risks, leading to adverse effects, such as headaches, digestive disorders, and abnormal blood pressure.
View Article and Find Full Text PDFBackground: Unhealthy diets contribute to the onset and progression of chronic kidney disease (CKD), with poor dietary habits identified as significant lifestyle factors that elevate CKD risk.
Methods: Data from the UK Biobank cohort, which included over 500,000 participants aged 40-69 from diverse regions of England, Wales, and Scotland, were analyzed. Participants, who completed at least one online 24-hour dietary recall assessment, were included in the study.
3-Hydroxyacyl-CoA dehydratase 2 (HACD2), an obesity-related gene involved in the elongation of long-chain fatty acids, is highly expressed in pancreatic cancer (PC) and is associated with patient prognosis. Interestingly, the study reveals that HACD2 mediated the proliferation of PC cells in a dehydratase-independent manner, affecting the downstream glycolytic pathway. Mechanistically, HACD2 promotes PC cells proliferation by binding to E3 ubiquitin-protein ligase parkin (PRKN) and enhancing pyruvate kinase PKM (PKM2) dissociation from PRKN, resulting in reduced ubiquitination of PKM2 and increased dimerization of PKM2, which subsequently promote c-Myc expression and tumor growth.
View Article and Find Full Text PDFCobalt-nitrogen-carbon (CoNC) materials are regarded as promising low-cost electrocatalysts for the oxygen reduction reaction (ORR). However, their susceptibility to deactivation and poor stability in acidic media limits their practical applications. In this study, we develop cobalt (Co) and manganese (Mn) embedded in nitrogen-doped carbon (CoMnNC) dual-site catalysts by incorporating Mn into CoNC and leverage a synergistic dual-catalysis strategy to optimize both activity and stability.
View Article and Find Full Text PDFTitanium dioxide nanoparticles (TiO NPs) have been widely used in agriculture, which increased the risk to soil-plant systems. Studies have demonstrated that TiO NPs can induce phytotoxicity. However, the toxicity mechanisms, particularly under the stress of TiO NPs with different crystalline forms, remain inadequately reported.
View Article and Find Full Text PDFThe prognosis for Cholangiocarcinoma (CCA) is unfavorable, necessitating the development of new therapeutic approach such as magnetic hyperthermia therapy (MHT) which is induced by magnetic nano-particle (MNPs) drug to bridge the treatment gap. Given the deep location of CCA within the abdominal cavity and proximity to vital organs, accurately predict the individualized treatment effects and safety brought by the distribution of MNPs in tumor will be crucial for the advancement of MHT in CCA. The Mimics software was used in this study to conduct three-dimensional reconstruction of abdominal computed tomography (CT) and magnetic reso-nance imaging images from clinical patients, resulting in the generation of a realistic digital geometric model representing the human biliary tract and its adjacent structures.
View Article and Find Full Text PDFHydrogen (H) remains a pivotal clean energy source, and the emergence of Solar-powered Microbial Photoelectrochemical Cells (MPECs) presents promising avenues for H production while concurrently aiding organic matter degradation. This study introduces an MPEC system employing a g-CN/CQDs/BiOBr photocathode and a bioanode, successfully achieving simultaneous H production and sludge reduction. The research highlights the effective formation of a Z-type heterojunction in the g-CN/CQDs/BiOBr photocathode, substantially enhancing the photocurrent response under light conditions.
View Article and Find Full Text PDFObjective: The association of coffee and tea consumption with osteoporosis is highly controversial, and few studies have focused on the combined effects of the two beverages. This study aimed to investigate the independent and combined associations of coffee and tea consumption with osteoporosis risk.
Methods: A prospective cohort study involving 487,594 participants aged 38-73 years from the UK Biobank was conducted.
A number of image dehazing techniques depend on the estimation of atmospheric light intensity. The majority of dehazing algorithms do not incorporate a physical model to estimate atmospheric light, leading to reduced accuracy and significantly impacting the effectiveness of dehazing. This article presents a novel approach for estimating atmospheric light using the polarization state and polarization degree gradient of the sky.
View Article and Find Full Text PDFSex pheromones, which consist of multiple components in specific ratios promote intraspecific sexual communications of insects. Plutella xylostella (L.) is a worldwide pest of cruciferous vegetables, the mating behavior of which is highly dependent on its olfactory system.
View Article and Find Full Text PDFSuccinate dehydrogenase (SDH) is an important inner mitochondrial membrane-bound enzyme involved in redox reactions during the tricarboxylic acid cycle. Therefore, a series of novel chitosan derivatives were designed and synthesized as potential microbicides targeting SDH and precisely characterized by FTIR, H NMR and SEM. Their antifungal and antibacterial activities were evaluated against Botrytis cinerea, Fusarium graminearum, Staphylococcus aureus and Escherichia coli.
View Article and Find Full Text PDFObjective: Genetic and lifestyles contribute to cholelithiasis, but the impact of adhering to healthy lifestyle on cholelithiasis risk remains uncertain. We aimed to assess combined lifestyle factors and a polygenic risk score on incident cholelithiasis.
Methods: We utilized cholelithiasis genome-wide association study (GWAS) data from FinnGen study, constructing varied polygenic risk score (PRS), and applied them to 317,640 UK Biobank participants.
Background: Roux-en-Y reconstruction is a common anastomosis technique during gastrectomy in gastric cancer. There is a lack of studies on gallstones after Roux-en-Y reconstruction gastrectomy. This study investigated the incidence and potential risk factors associated with gallstones after Roux-en-Y reconstructive gastrectomy in gastric cancer.
View Article and Find Full Text PDFEosinophilic pneumonia (EP) is a rare but noteworthy adverse effect linked to dupilumab, an interleukin-4 (IL-4) and IL-13 inhibitor used in the managing atopic diseases. The underlying mechanisms, potential predisposing factors, clinical characteristics, and optimal management strategies for dupilumab-induced EP remain unclear. We report a 71-year-old patient who developed acute EP after the first 600-mg dose of dupilumab.
View Article and Find Full Text PDFObjective: The association between Metabolic Syndrome (MetS), its components, and the risk of osteoarthritis (OA) has been a topic of conflicting evidence in different studies. The aim of this present study is to investigate the association between MetS, its components, and the risk of OA using data from the UK Biobank.
Methods: A prospective cohort study was conducted in the UK Biobank to assess the risk of osteoarthritis (OA) related to MetS.
Developing electrocatalysts with high activity and robust performance for large-scale seawater electrolysis to produce hydrogen holds immense significance. Herein, a highly active bifunctional electrode composed of amorphous cobalt-iron layered double hydroxides (CoFeLDH) and crystalline nickel phosphide (NiP) (denoted as CoFeLDH@NiP), is employed to boost hydrogen production through seawater electrolysis. The strong interface coupling effectively modifies the electronic structure at active sites, thereby accelerating the catalytic reaction kinetics.
View Article and Find Full Text PDFBackground And Aims: The long-term impact of maternal smoking during pregnancy [MSDP] on the risk of Crohn's disease [CD] and ulcerative colitis [UC] in adult offspring remains uncertain. The present study aimed to investigate the individual and combined effects of early life exposure [MSDP], offspring personal behaviour [smoking], and genetic risk on the development of CD and UC in adult offspring.
Methods: We conducted a prospective cohort study using UK Biobank data, including 334 083 participants recruited between 2006 and 2010, with follow-up until December 31, 2021.
Background: Gut microbiome dysbiosis has been implicated in various gastrointestinal and extra-gastrointestinal diseases, but evidence on the efficacy and safety of fecal microbiota transplantation (FMT) for therapeutic indications remains unclear.
Methods: The gutMDisorder database was used to summarize the associations between gut microbiome dysbiosis and diseases. We performed an umbrella review of published meta-analyses to determine the evidence synthesis on the efficacy and safety of FMT in treating various diseases.