Evaluation of salivary interleukin-17 and developmental endothelial locus-1 in patients with periodontitis with and without type 2 diabetes mellitus.

Background: Bidirectional positive relationship between periodontitis and type 2 diabetes mellitus (T2DM) has been recognized, interleukin 17 (IL-17) and developmental endothelial locus-1 (Del-1) are proposed to play roles in periodontitis and T2DM. This study aims to investigate the association of IL-17 and Del-1 in patients with periodontitis with and without T2DM by measuring their salivary levels.

Methods: A total of 80 participants were enrolled in a cross-sectional study and divided into healthy (H, n = 27), periodontitis (P, n = 29) and periodontitis with diabetes (PDM, n = 24) groups based on their periodontal and diabetic examination results.

An Operating Stiffness Controller for the Medical Continuum Robot Based on Impedance Control.

Continuum manipulators can conform to curvilinear paths and manipulate objects in complex environments, which makes it emerging to be applied in minimally invasive surgery (MIS). However, different and controllable operating stiffness of the continuum manipulator is required during different stages of surgery to achieve safe access or stable and precise operation. This work proposes an operating stiffness controller (OSC) for the typical tendon-driven continuum manipulator based on the variable impedance control method with Lagrangian dynamic modeling.

Near-infrared fluorescent indolizine-dicyanomethylene-4H-pyran hybrids for viscosity imaging in living cells.

The development of near-infrared organic fluorescent dyes with tunable emission profiles is highly required in the field of biological sensing and imaging. In this paper, we designed and synthesized two organic fluorescent dyes, DCM-1 and DCM-2, through the hybridization of indolizine and dicyanomethylene-4H-pyran skeleton. These two compounds show near-infrared fluorescence with emission maximum approximately at 640 and 680 nm, respectively.

Digitally measured exposed root surface area for predicting the effectiveness of modified coronally advanced tunnel combined de-epithelialized gingival grafting in the treatment of multiple adjacent gingival recessions.

Objectives: To assess the predictive value of baseline digitally measured exposure root surface area (ERSA) on the effectiveness of modified coronally advanced tunnel and de-epithelialized gingival grafting (MCAT + DGG) technique for the treatment of multiple adjacent gingival recessions (MAGRs).

Materials And Methods: A total of 96 gingival recessions (48 RT1 and 48 RT2) from 30 subjects were included. ERSA was measured on the digital model obtained by intraoral scanner.

Inflammation markers and the risk of hypertension in people living with HIV.

Background: The incidence of hypertension is high in people living with HIV (PLWH). High-sensitivity C-reactive protein (hsCRP), systemic inflammation response index (SIRI), and neutrophil-to-monocyte ratio (NMR) are considered economic and convenient parameters that reflect the levels of inflammation in patients. Our aim was to explore whether indirect inflammation markers are associated with hypertension in PLWH.

Clinical and computed tomographic evaluations of periodontal phenotypes in a Chinese population: a cross-sectional study.

Objectives: To investigate the diagnostic value of probe transparency related to gingival thickness (GT) and keratinized gingival width (KGW) at individual and site levels and explore the relationship of buccal bone plate thickness (BT) with GT and KGW.

Materials And Methods: A total of 1,606 teeth from 167 patients with periodontally healthy maxillary anterior region were included. GT was measured with probe transparency and transgingival probing.

CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer.

Background: A growing number of studies have focused on the regulatory role of circular RNAs (circRNAs) in a variety of cancers. The purpose of this study was to investigate the effect of circRNA Keratin 14 (circKRT14) on the progression of esophageal cancer (EC).

Methods: The levels of circKRT14, miR-1256 and E2F transcription factor 3 (E2F3) were analyzed by real-time quantitative polymerase chain reaction (qRT-PCR) and western blot.

Survival of nonsurgically splinted mandibular anterior teeth during supportive maintenance care in periodontitis patients.

Background/purpose: Splinting mobile teeth is a choice to improve the patient's oral comfort. The purpose of this study was to assess the survival and stability of mobile anterior mandibular teeth after splinting in patients with periodontitis undergoing supportive periodontal therapy (SPT).

Materials And Methods: Patients with splinted mobile anterior mandibular teeth were assessed retrospectively.

Periodontitis induced by drives impaired glucose metabolism in mice.

Periodontitis has been demonstrated to be bidirectionally associated with diabetes and has been recognized as a complication of diabetes. As a periodontal pathogen, is a possible pathogen linking periodontal disease and systemic diseases. It has also been found to be involved in the occurrence and development of diabetes.

Evaluation of salivary biomarkers for the diagnosis of periodontitis.

Background: Salivary interleukin (IL)-1β, matrix metalloproteinase (MMP)-8, pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and Porphyromonas gingivalis (Pg) are related to periodontitis. This study aimed to investigate the diagnostic potential of these biomarkers and to build a prediction panel for diagnosing periodontal disease.

Methods: A total of 80 participants were enrolled in a cross-sectional study and divided into healthy (n = 25), gingivitis (n = 24), and periodontitis (n = 31) groups based on their periodontal exam results.

Hybrid Polydopamine/Ag Shell-Encapsulated Magnetic FeO Nanosphere with High Antibacterial Activity.

The bacteria, which usually contaminate water environment, often cause terrible infectious diseases thus seriously threaten people's health. To meet the increasing requirement of the public health care, an easily separable nanomaterial with sustainable anti-bacteria performance is required. This work reports a FeO@PDA/Ag/PDA core-shell nanosphere in which the Ag nanocrystals immobilized on the magnetic carrier are protected by an external polydopamine (PDA) layer.

Polydopamine protected hollow nanosphere with AuAg-nanoframe-core@Carbon@AuAg-nanocrystals-satellite hybrid nanostructure (AuAg@C@AuAg/PDA) for enhancing nanocatalysis.

This work reported a facile method for fabricating multi-layered polydopamine (PDA) encapsulated AuAg@C@AuAg core/shell nanosphere with a hollow interior. During the synthetic process, the preliminary Ag@C nanosphere is easily covered by an AuAg/PDA hybrid layer through the in situ redox-oxidized polymerization to form the Ag-AuAg@C@AuAg/PDA precursor, in which the AuAg bimetallic nanocrystals are simultaneously obtained via the electrochemical substitution reaction. After etching the residue Ag core, the final AuAg@C@AuAg/PDA hybrid nanosphere is achieved and the inner AuAg shows a unique nanoframe-like nanostructure.

In situ redox-oxidation polymerization for magnetic core-shell nanostructure with polydopamine-encapsulated-Au hybrid shell.

This work reports a facile one-step method for the fabricating FeO@Au/polydopamine sandwich-like core-shell nanostructure, in which the Au/polydopamine (Au/PDA) hybrid shell is obtained via an in situ redox-oxidation polymerization between the HAuCl and dopamine. The content of Au nanocrystals, shell thickness, and particle sizes are tunable by varying the experimental parameters. Intriguingly, this general method can be applied for different functional nanostructures such as the β-FeOOH@Au/PDA, SiO@Au/PDA, and CNT@Au/PDA nanocomposites.

Magnetically Separable Nanocatalyst with the FeO Core and Polydopamine-Sandwiched Au Nanocrystal Shell.

This work reports a novel FeO@polydopamine/Au/polydopamine core/shell nanocomposite toward a magnetically separable nanocatalyst. Because the polydopamine (PDA) layer-sandwiched Au nanocrystals were prepared by a layer-by-layer method, the content of Au could be controlled by varying the Au shell number (such as burger-like FeO@PDA/Au/PDA/Au/PDA). FeO@PDA/Au/PDA exhibited excellent catalytic activity in reducing p-nitrophenol because the substrate could penetrate the PDA shell.

The effect of concentrated growth factors in the treatment of periodontal intrabony defects.

Aim: To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment.

Methods: Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery.

[Effect of regenerative therapy for the furcation involvements of mandibular molars evaluated by cone-beam computed tomography].

Objective: To evaluate the effect of regenerative therapy for the treatment of furcation involvements of mandibular molars with cone-beam computed tomography (CBCT).

Methods: In the study, 38 furcation involvements of mandibular molars were included and randomly divided into two groups. The experimental group accepted guided tissue regeneration and bone graft therapy, and the control group only flap surgery.

The accuracy of cone-beam computed tomography in assessing maxillary molar furcation involvement.

Aim: The aim of this study was to investigate the accuracy of cone-beam computed tomography (CBCT) in assessing maxillary molar furcation involvement (FI).

Materials And Methods: Fifteen patients with generalized chronic periodontitis after initial therapy were recruited. CBCT was performed in maxillary molars with probing pocket depths of ≥6 mm and advanced FI, and CBCT images were analysed.

Intracellular adhesion molecule-1 is regulated by porphyromonas gingivalis through nucleotide binding oligomerization domain-containing proteins 1 and 2 molecules in periodontal fibroblasts.

Background: The mechanism by which Porphyromonas gingivalis regulates intracellular adhesion molecule 1 (ICAM-1) expression in human periodontal ligament cells (hPDLCs) and human gingival fibroblasts (hGFs) is unknown. The aim of this study is to investigate whether nucleotide binding oligomerization domain-containing protein (NOD) 1 and NOD2 are involved in this process and the clinical significance of ICAM-1 in periodontitis.

Methods: hPDLCs and hGFs were treated with P.

[Effect of periodontal initial therapy on the serum level of lipid in the patients with both periodontitis and hyperlipidemia].

Objective: To observe the effect of periodontal initial therapy on the serum level of lipid in the patients with both periodontitis and hyperlipidemia.

Methods: Twenty patients with both hyperlipidemia and moderate to severe chronic periodontitis were enrolled in this study. Periodontal parameters [plaque index (PLI), bleeding on probing (BOP), bleeding index (BI), probing depth (PD) and attachment level (AL)] were evaluated prior to and 3 months after periodontal initial therapy.