Publications by authors named "Jinyoung Youn"

Background And Purpose: The hot cross bun (HCB) sign is a hallmark feature of multiple system atrophy with predominant cerebellar ataxia (MSA-C), typically observed in advanced stages of the disease; however, it can also present in other conditions such as spinocerebellar ataxia (SCA), making the differentiation challenging. The middle cerebellar peduncle (MCP) sign may be observed in various medical conditions and in healthy individuals. We hypothesized that the inferior cerebellar peduncle (ICP), known to be affected in MSA-C, may exhibit hyperintensity on fluid-attenuated inversion recovery (FLAIR) imaging, potentially aiding in differentiating MSA-C from SCA.

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  • * Among 232 probands, 66 individuals (28.4%) had genetic diagnoses and 12 (5.2%) had non-genetic causes, highlighting the challenges faced in diagnosing those with probable genetic origins or early symptom onset.
  • * The research emphasizes that integrating sequencing methods not only improves diagnostic accuracy but also facilitates better health management strategies, including surveillance and personalized planning for affected adults.
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Background: Reduced cerebrospinal fluid (CSF) clearance may play a vital role in the pathogenesis of normal pressure hydrocephalus (NPH), but the radiologic marker is yet to be elucidated.

Objectives: This open-label study presents two novel neuroimaging biomarkers based on enlarged perivascular spaces (ePVS) of the sub-insular territory: the Hedgehog and Hedgehog-Halo (H-H) sign, designed to predict gait symptom severity and tap response in NPH.

Methods: We retrospectively reviewed 203 patients with possible NPH with baseline magnetic resonance imaging and gait analyses before and after lumbar puncture (LP).

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  • The study explores the relationship between spinal cord injury (SCI) and the risk of Parkinson's disease (PD), which has not been clearly defined before.
  • Using data from the Korean National Health Insurance Service, researchers compared 7,182 SCI patients to 24,844 matched controls over a mean follow-up of 4.31 years.
  • Results indicate that SCI patients have a higher risk of developing PD, especially those with disabilities and injuries at the thoracic level, with cervical injuries posing a greater risk for those without disabilities.
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Parkinson's disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms.

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Background And Purpose: The wearing-off (WO) phenomenon is the most common motor complication in advanced Parkinson's disease (PD), but its identification remains challenging. The 9- and 19-item Wearing-off Questionnaires (WOQ-9 and WOQ-19) are self-assessment tools for motor and nonmotor symptoms that are widely used for WO screening. We produced Korean versions of the WOQ-19 and WOQ-9 (K-WOQ-19 and K-WOQ-9) and investigated their validity and reliability.

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  • Rare diseases are mostly genetic and often have neurological symptoms, making their diagnosis and treatment complicated due to their rarity and low prevalence.
  • A national registry has been established in Korea to focus on three specific rare diseases that cause gait disturbances, collecting clinical data and biological materials from patients.
  • The registry aims to identify genetic variants specific to Korean patients and discover biomarkers to improve early diagnosis and treatment development for these conditions.
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  • - The study aimed to evaluate the reliability and validity of the Korean version of the SCales for Outcomes in Parkinson's Disease-Cognition (K-SCOPA-Cog) for assessing cognition in Parkinson's disease patients in South Korea.
  • - A total of 129 patients participated, and various statistical methods, including Cronbach's alpha and Spearman’s rank correlation, were employed to test the reliability and concurrent validity against established cognitive assessments.
  • - Results showed that the K-SCOPA-Cog has strong reliability (Cronbach's alpha of 0.797, ICC of 0.887) and a significant correlation with other cognitive measures (MOCA-K and K-MMSE), indicating it is a valid tool for cognitive assessment in this
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Background Exercise is crucial for the well-being of people with Parkinson's disease (PD). Although there are challenges to exercising with PD, mobile apps are seen as potential solutions, though their impact is not yet fully understood. We developed a mobile app and a home-based exercise program specialised for people with PD and investigated the effect of the mobile exercise app for the people with PD.

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Objective: Exercise can improve both motor and nonmotor symptoms in people with Parkinson's disease (PwP), but there is an unmet need for accessible and sustainable exercise options. This study aimed to evaluate the effect, feasibility, and safety of a regularly performed live-streaming tele-exercise intervention for PwP.

Methods: A live-streaming exercise intervention for PwP was implemented twice a week for 12 weeks.

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This study aimed to investigate the association between nonarteritic anterior ischemic optic neuropathy (NAION) and Parkinson's disease (PD) using a retrospective, nationwide, population-based cohort in South Korea. This study utilized data from the Korean National Health Insurance database, including 43,960 NAION patients and 219,800 age- and sex-matched controls. Cox proportional hazards regression models were used to assess the risk of developing PD in the NAION group compared to the control group after adjusting for various confounding factors.

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Background And Purpose: Previous studies have examined the risk of stroke in patients with Parkinson disease (PD), but the incidence of PD onset among stroke patients and its risk according to severity of poststroke disabilities have scarcely been investigated. This study aims to determine whether the risk of PD is increased among stroke patients using a retrospective cohort with a large population-based database.

Methods: We used data collected by the Korean National Health Insurance Service from 2010 to 2018 and examined 307,361 stroke patients and 380,917 sex- and age-matched individuals without stroke to uncover the incidence of PD.

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Introduction: Subjective cognitive complaints (SCC) refer to self-reported cognitive decline that may or may not be reflected in objective neuropsychological evaluations. Such SCC are prevalent in neurodegenerative diseases, including Parkinson's disease (PD), but the prevalence and clinical features in patients with progressive supranuclear palsy (PSP) have not been investigated.

Methods: We recruited 83 PSP patients without dementia and investigated their SCC using a semi-structured interview.

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  • - This study investigates waiting impulsivity in patients with progressive supranuclear palsy-Richardson's syndrome (PSP-RS) by examining a behavior known as the "jumping the gun" (JTG) sign, where patients clap prematurely before a start signal.
  • - Researchers compared two groups of PSP-RS patients: those with the JTG sign (JTG +) and those without it (JTG -), finding that JTG + patients scored worse on cognitive tests, experienced more falls, and had distinct neural connectivity in the nucleus accumbens (NAc).
  • - The results suggest that the JTG sign may serve as a marker for waiting impulsivity in PSP-RS, enhancing understanding of this behavior
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Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective and evidence-based treatment for idiopathic Parkinson's disease (iPD). A minority of patients does not sufficiently benefit from STN-DBS.

Objective: The predictive validity of the levodopa challenge for individual patients is analyzed.

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  • Dystonia is a complex movement disorder with various genetic causes, and this study investigates the role of whole exome sequencing (WES) in identifying these genetic variants in Korean patients with young-onset dystonia.
  • Researchers performed WES on 43 patients, finding 11 disease-causing variants in 9 individuals, which highlights the potential for WES to enhance the understanding and diagnosis of dystonia, particularly in cases that begin in childhood or are generalized.
  • The study suggests that combining clinical assessments, brain imaging, and genetic testing can improve the diagnosis and management of dystonia patients, paving the way for more personalized treatment options.
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Stridor is a rare but important non-motor symptom that can support the diagnosis and prediction of worse prognosis in multiple system atrophy. Recording sounds generated during sleep by video-polysomnography is recommended for detecting stridor, but the analysis is labor intensive and time consuming. A method for automatic stridor detection should be developed using technologies such as artificial intelligence (AI) or machine learning.

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  • A study looked at how age-related macular degeneration (AMD) is linked to Parkinson's disease (PD) in older people in South Korea.
  • It found that people with AMD and vision problems (visual disability) are at a higher risk of developing PD than those without vision problems.
  • The results suggest that AMD and PD might be connected in a way that involves similar changes in the brain.
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Despite various neurologic symptoms of Poland syndrome (PS), parkinsonism was never reported in PS, and the response to the treatment of parkinsonism was not studied before. We report a case of ipsilateral parkinsonism in PS, similar to hemiatrophy-hemiparkinsonism, with a good response to levodopa and subthalamic deep brain stimulation.

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Orthostatic hypotension (OH) is a common non-motor symptom in Parkinson's disease (PD). OH can cause cerebral and retinal hypoperfusion and is associated with microvascular damage in PD. Optical coherence tomography angiography (OCTA) is a non-invasive technology that can be used to visualize the retinal microvasculature and detect microvascular damage in PD.

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