Publications by authors named "Jinyeon Jo"
East Asian populations exhibit a genetic predisposition to obesity, yet comprehensive research on these traits is limited. We conducted a genome-wide association study (GWAS) with 93,673 Korean subjects to uncover novel genetic loci linked to obesity, examining metrics such as body mass index, waist circumference, body fat ratio, and abdominal fat ratio. Participants were categorized into non-obese, metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) groups.
View Article and Find Full Text PDFThe bidirectional effect of hyperuricemia on chronic kidney disease (CKD) underscores the importance of hyperuricemia as a risk factor for CKD. We evaluated the effect of hyperuricemia on the presence and development of CKD after considering genetic background by calculating polygenic risk scores (PRSs). We employed genome-wide association study summary statistics-excluding the United Kingdom Biobank (UKB) datasets among published CKD Gen Consortium papers-to calculate the PRSs for CKD in white background subjects.
View Article and Find Full Text PDFArticle Synopsis
- Genetic factors, lifestyle, and diet, particularly salt and potassium intake, contribute significantly to the risk of hypertension, especially in Asian populations.
- The study analyzed data from 41,351 individuals to understand how genetic predisposition (measured by polygenic risk scores) interacts with sodium and potassium consumption in relation to blood pressure levels.
- Results indicated that higher sodium intake and lower potassium intake, combined with a higher polygenic risk score, significantly increased the risk of developing hypertension; therefore, lifestyle changes and sodium restriction are crucial for prevention in high-risk individuals.
Background: The effect of dyslipidemia on kidney disease outcomes has been inconclusive, and it requires further clarification. Therefore, we aimed to investigate the effects of genetic factors on the association between dyslipidemia and the risk of chronic kidney disease (CKD) using polygenic risk score (PRS).
Methods: We analyzed data from 373,523 participants from the UK Biobank aged 40-69 years with no history of CKD.
Background: The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population.
Methods: In total, 5011 participants (average age, 54 years; 45% men) were enrolled from a community-based prospective cohort.
This study examined the single-nucleotide polymorphism heritability and genetic correlations of cognitive abilities and brain structural measures (regional subcortical volume and cortical thickness) in middle-aged and elderly East Asians (Korean) from the Gwangju Alzheimer's and Related Dementias cohort study. Significant heritability was found in memory function, caudate volume, thickness of the entorhinal cortices, pars opercularis, superior frontal gyri, and transverse temporal gyri. There were 3 significant genetic correlations between (i) the caudate volume and the thickness of the entorhinal cortices, (ii) the thickness of the superior frontal gyri and pars opercularis, and (iii) the thickness of the superior frontal and transverse temporal gyri.
View Article and Find Full Text PDFAsthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors. This study aimed to identify novel genes underlying both asthma and COPD using genome-wide association study (GWAS) to differentiate between the two diseases.
View Article and Find Full Text PDFRecent genetic studies have identified physical activity (PA)-susceptible loci in European ancestry subjects; however, due to considerable genetic differences, these findings are not likely extendable to East Asian populations. Therefore, the present study aimed to identify significantly associated PA-susceptible loci using genome-wide association studies (GWASs) with East Asian (EAS) subjects and to generalize the findings to European (EUR) ancestries. The mRNA levels of genes located near the genome-wide significantly associated single-nucleotide polymorphisms (SNP) were compared under PA and control conditions.
View Article and Find Full Text PDFArticle Synopsis
- This study aimed to identify new genetic factors related to Alzheimer's disease (AD) by analyzing brain imaging data from 2,643 Koreans with varying cognitive conditions.
- A specific genetic variant (rs77359862) in the SHARPIN gene was found to negatively impact brain areas linked to memory and cognition, suggesting it increases AD risk.
- The research also noted that this variant affects important protein interactions involved in cellular signaling pathways, highlighting SHARPIN's potential role in the development of AD.