Design, Synthesis of Dienthiazole Derivatives, and Evaluation of Aphicidal Activity.

Nitrogen-containing heterocycles have attracted attention for the development of chemicals because of their many types, high physiological activities, and ease of synthesis. Aphids are severe pests found worldwide that cause serious losses in crop yield and quality every year. In this study, a series of novel dienolone thiazole derivatives were synthesized using dienolone acetate as the parent molecule.

Sulfur metabolism and response to light in Ulva prolifera green tides.

The outbreak of Ulva prolifera blooms causes significant changes in the coastal sulfur cycle due to the high production of dimethylsulfoniopropionate (DMSP) and the emission of dimethylsulfide (DMS). However, the sulfur metabolism mechanism of U. prolifera has not been thoroughly investigated.

The Effects of Mindfulness on Shame: Exploring Mediation by Cognitive Flexibility and Self-Compassion in a Chinese Adult Population.

To examine the effects of mindfulness on shame and the mechanisms mediated by cognitive flexibility and self-compassion in a Chinese adult population in daily life, we conducted two studies. Study 1 was a cross-sectional study using the Five-Factor Mindfulness Questionnaire, the Cognitive Flexibility Inventory, the Self-Compassion Scale, and the Self-Conscious Affect-3, which were administered to 481 adults in Beijing and Chengdu. For Study 2, an 8-month follow-up study was conducted on 128 of the adults.

Retraction: The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice.

[This retracts the article DOI: 10.1039/C9RA07262D.].

Combining mechanical ball-milling with melt-polymerization to fabricate polyimide covalent organic frameworks towards high-performance sodium-ion batteries.

Melt-polymerization and mechanical ball-milling were combined to achieve the facile mass production of polyimide covalent organic frameworks (COFs) towards high-performance sodium-ion batteries. The as-obtained COFs were demonstrated with high utilization of active sites (>83.0%) and COFs with smaller pore sizes were proved to deliver better performance with a specific capacity of 213.

D4A: An efficient and effective defense across agnostic adversarial attacks.

Recent studies show that Graph Neural Networks (GNNs) are vulnerable to structure adversarial attacks, which draws attention to adversarial defenses in graph data. Previous defenses designed heuristic defense strategies for specific attacks or graph properties, and are no longer sufficiently robust across all these attacks. To address this problem, we discuss the abnormal behaviors of GNNs in structure perturbations from a posterior distribution perspective.

Rethinking the impact of noisy labels in graph classification: A utility and privacy perspective.

Graph neural networks (GNNs) based on message-passing mechanisms have achieved advanced results in graph classification tasks. However, their generalization performance degrades when noisy labels are present in the training data. Most existing noisy labeling approaches focus on the visual domain or graph node classification tasks and analyze the impact of noisy labels only from a utility perspective.

Real-world clinical data-driven modelling on the initiation time of antiviral prophylaxis among pregnant women with chronic hepatitis B infection.

Background & Aims: The risk of mother-to-child transmission (MTCT) for pregnant women with chronic hepatitis B (CHB) infection still exists, especially for those with high HBV DNA level. The guidelines for initiating prophylaxis for pregnant women with CHB vary across countries. We aimed to explore the latest prophylaxis initiation time for these women.

Plant defense metabolites influence the interaction between an insect herbivore and an entomovirus.

The tri-trophic interaction of plants, insect herbivores, and entomoviruses is an important topic in ecology and pest control. The susceptibility of insect herbivores to entomoviruses (e.g.

Chaperonin-containing TCP1 subunit 6A inhibition via TRIM21-mediated K48-linked ubiquitination suppresses triple-negative breast cancer progression through the AKT signalling pathway.

Background: Triple-negative breast cancer (TNBC) is distinguished by a significant likelihood of distant recurrence and an unfavourable prognosis. However, the underlying molecules and mechanisms have not been fully elucidated.

Methods: We investigated the expression profile and clinical relevance of chaperonin-containing TCP1 subunit 6A (CCT6A) in TNBC.

Psychometric validation and refinement of the Chinese Interoceptive Accuracy Scale (IAS) in general population and patients with chronic pain.

Objective: Interoception plays an important role in psychological functioning and mental and physical health. Recent studies have highlighted the need to distinguish between different aspects of interoception in self-report measures, including subjective interoceptive accuracy and attention. However, there is currently no questionnaire available in Chinese to measure either of these aspects, especially in patients with chronic pain conditions.

Long-term efficacy and safety of stapokibart for moderate-to-severe atopic dermatitis: 52-week results from a phase 3 trial.

Background: Management of moderate-to-severe atopic dermatitis (AD) needs long-term therapy. Stapokibart is a humanized monoclonal antibody targeting interleukin-4 receptor α subunit (IL-4Rα), a shared receptor for IL-4 and IL-13 which are key pathogenic drivers of AD. In a pivotal phase 3 trial (NCT05265923), significant higher proportions of adult AD patients receiving stapokibart than placebo achieved ≥75% improvement from baseline in Eczema Area and Severity Index (EASI-75; 66.

Parasite-enhanced immunotherapy: transforming the "cold" tumors to "hot" battlefields.

Immunotherapy has emerged as a highly effective treatment for various tumors. However, the variable response rates associated with current immunotherapies often restrict their beneficial impact on a subset of patients. Therefore, more effective treatment approaches that can broaden the scope of therapeutic benefits to a larger patient population are urgently needed.

Multisite Mutagenesis of 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Enhances Rice Resistance to HPPD Inhibitors and Its Carotenoid Contents.

While frequently used herbicides display limited efficacy against herbicide-resistant weeds, it becomes imperative to explore novel herbicides that ensure both effective weed management and environmental safety. Though 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitory herbicides like mesotrione are prevalent in maize weed management, their integration into rice production is hindered due to the inherent sensitivity of rice HPPD (). In this study, a mutant allele of featuring six amino acid substitutions, termed -6M, maintains enzymatic activity in 200 μm mesotrione while the wild type can only withstand 1 μm.

Long-Term Efficacy and Safety of Stapokibart in Adults with Moderate-to-Severe Atopic Dermatitis: An Open-Label Extension, Nonrandomized Clinical Trial.

Background: Stapokibart/CM310, a humanized monoclonal antibody targeting the interleukin-4 receptor α chain, has shown promising treatment benefits in patients with moderate-to-severe atopic dermatitis in previous phase II clinical trials.

Objective: We aimed to evaluate the long-term efficacy and safety of stapokibart in adults with moderate-to-severe atopic dermatitis.

Methods: Enrolled patients who previously completed parent trials of stapokibart received a subcutaneous stapokibart 600-mg loading dose, then 300 mg every 2 weeks up to 52 weeks.

Structural Elucidation and Anti-Tumor Activity of a Polysaccharide (CP2-S) from Fruit Bodies.

A polysaccharide (CP2-S), consisting of glucose with a weight average molecular weight of 5.9 × 10, was purified from the fruit bodies of . In this work, the corresponding structure and anti-tumor activity in vivo were investigated.

Four three-dimensional rare earth metal - organic framework fluorescent sensor for efficient detection of gentamicin sulfate and Fe.

Excessive use of gentamicin sulfate can cause severe nephrotoxicity and ototoxicity, abnormal levels of Fe intake can also cause serious damage to body. Therefore, establishing a fast and accurate detection method for the above-mentioned substances is of great significance. However, traditional detection methods such as high-performance liquid chromatography still have certain problems such as high cost and complex operation.

Deep ultraviolet laser at 223.8 nm with adjustable repetition rate and narrow pulse width.

We presented the first, to our knowledge, demonstration of an ultraviolet (UV) laser at 223.8 nm by six-harmonic generation of an electro-optic Q-switched cavity dumping 1342 nm Nd:YVO laser. It offers high power, constant short pulse duration, and adjustable pulse repetition rate.